New Immunotherapies Against Lymphoma
The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer
OF OUR RESEARCH AXIS
Our work focuses on the innate and adaptive immune responses in lymphoma with a special emphasis on the study of γδ T cells and macrophages, and the mechanisms of regulation of immune checkpoint expression.
Recently, we have introduced single cell RNAseq techniques and developed bionformatics tools allowing us to explore the functional status and maturation/differentiation stage of cytotoxic effectors at the single cell level in lymphoma lymph node or blood samples.
The privileged access to different cohorts of lymphoma patients has also allowed us to identify biomarkers of response in lymphoma and establish a screening platform based on 3D models from lymphoma patients’ samples.
microenvironment & gamma delta T cells
immune escape mechanisms & post-transcriptional regulation
of immune checkpoints
biomarkers of response/progression
single cell RNAseq
Single cell mapping of γδT cells and vasculature in lymphoma: a study for localization and functional characterization of γδ lymphocytes infiltrating human lymphomas.
Pr Camille Laurent
Targeting the tumor microenvironment: blocking tumor-associated macrophages and activating γδ T lymphocytes.
Dr Mary Poupot
Characterization and therapeutic targeting of a new immunoregulatory mechanism
Dr Don Marc Franchini
Leukemia and immune cell resistance to targeted therapies in chronic lymphocytic leukemia (cll)
Dr Anne Quillet-Mary
Identification of immuno-escapement mechanisms by multiomics approaches.
Pr Camille Laurent
PDLS at the heart of the identification of new therapeutic targets in NHL
Dr Christine Bezombes
parternships & funding
Centre de Recherches en Cancérologie de Toulouse (Oncopole)
Toulouse – FR
05 82 74 15 75
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