NoLymIT :

New Immunotherapies Against Lymphoma

The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer



Our work focuses on the innate and adaptive immune responses in lymphoma with a special emphasis on the study of γδ T cells and macrophages, and the mechanisms of regulation of immune checkpoint expression.

Recently, we have introduced single cell RNAseq techniques and developed bionformatics tools allowing us to explore the functional status and maturation/differentiation stage of cytotoxic effectors at the single cell level in lymphoma lymph node or blood samples.

The privileged access to different cohorts of lymphoma patients has also allowed us to identify biomarkers of response in lymphoma and establish a screening platform based on 3D models from lymphoma patients’ samples.

B lymphoma/LLC

 microenvironment & gamma delta T cells

 immune escape mechanisms & post-transcriptional regulation
of immune checkpoints

biomarkers of response/progression

3D models

therapeutic screenings

single cell RNAseq

 bioinformatics tools




Armand, Marine, Michaël Degaud, Bruno Tesson, Cécile Laurent, Manon Vavasseur, Mélanie Parisot, Bénédicte Hoareau-Coudert, et al. “Exploring the Genetic Landscape of HCV-Related B-Cell Lymphomas Using Whole Exome Sequencing.” Leukemia, March 13, 2023.
Pont, Frédéric, Juan Pablo Cerapio, Pauline Gravelle, Laetitia Ligat, Carine Valle, Emeline Sarot, Marion Perrier, et al. “Single-Cell Spatial Explorer: Easy Exploration of Spatial and Multimodal Transcriptomics.” BMC Bioinformatics 24, no. 1 (January 27, 2023): 30.
Syrykh, Charlotte, Charlotte Chaouat, Elsa Poullot, Nadia Amara, Virginie Fataccioli, Marie Parrens, Alexandra Traverse-Glehen, et al. “Lymph Node Excisions Provide More Precise Lymphoma Diagnoses than Core Biopsies: A French Lymphopath Network Survey.” Blood 140, no. 24 (December 15, 2022): 2573–83.
Trecourt, Alexis, Marie Donzel, Juliette Fontaine, Hervé Ghesquières, Laurent Jallade, Gabriel Antherieu, Camille Laurent, Claire Mauduit, and Alexsandra Traverse-Glehen. “Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review.” Cancers 14, no. 22 (November 19, 2022): 5695.
Laurent, Camille, James R. Cook, Tadashi Yoshino, Leticia Quintanilla-Martinez, and Elaine S. Jaffe. “Follicular Lymphoma and Marginal Zone Lymphoma: How Many Diseases?” Virchows Archiv: An International Journal of Pathology, November 17, 2022.
Gondran, Camille, and Loïc Ysebaert. “[Drug approval: Mosunetuzumab - third-line therapy in follicular lymphoma].” Bulletin Du Cancer 109, no. 11 (November 2022): 1105–6.
Phelippeau, Mona, Christine Lefebvre, Marie-Christine Jacob, Charlotte Syrykh, Julien Ghelfi, Sylvain Carras, Camille Laurent, Lysiane Molina, and Séverine Valmary-Degano. “[Dasatinib-induced follicular lymphoid hyperplasia, an entity to know].” Annales De Pathologie, October 17, 2022, S0242-6498(22)00175-4.
Bouclet, Florian, Daphné Krzisch, Véronique Leblond, Cécile Tomowiak, Kamel Laribi, Loïc Ysebaert, Olivier Tournilhac, et al. “[Waldenström disease: News and perspectives in 2022].” Bulletin Du Cancer, October 10, 2022, S0007-4551(22)00350-2.
Feldman, Andrew L., Camille Laurent, Marina Narbaitz, Shigeo Nakamura, Wing C. Chan, Laurence de Leval, and Philippe Gaulard. “Classification and Diagnostic Evaluation of Nodal T- and NK-Cell Lymphomas.” Virchows Archiv: An International Journal of Pathology, October 10, 2022.
Lamaison, Claire, Juliette Ferrant, Pauline Gravelle, Alexandra Traverse-Glehen, Hervé Ghesquières, Marie Tosolini, Cédric Rossi, et al. “Histological Subtypes Drive Distinct Prognostic Immune Signatures in Classical Hodgkin Lymphoma.” Cancers 14, no. 19 (October 6, 2022): 4893.
Morschhauser, Franck, Loretta Nastoupil, Pierre Feugier, Jean-Marc Schiano de Colella, Hervé Tilly, Maria Lia Palomba, Emmanuel Bachy, et al. “Six-Year Results From RELEVANCE: Lenalidomide Plus Rituximab (R2) Versus Rituximab-Chemotherapy Followed by Rituximab Maintenance in Untreated Advanced Follicular Lymphoma.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 40, no. 28 (October 1, 2022): 3239–45.
Lapierre, Léopoldine, Charlotte Syrykh, Laetitia Largeaud, Bastien Cabarrou, Thomas Filleron, Lucie Oberic, Salim Kanoun, et al. “‘Accelerated Phase’ Chronic Lymphocytic Leukemia: Still an Intermediate Risk Disease in the Era of Targeted Therapies.” Hematological Oncology 40, no. 4 (October 2022): 805–8.
Campo, Elias, Elaine S. Jaffe, James R. Cook, Leticia Quintanilla-Martinez, Steven H. Swerdlow, Kenneth C. Anderson, Pierre Brousset, et al. “The International Consensus Classification of Mature Lymphoid Neoplasms: A Report from the Clinical Advisory Committee.” Blood 140, no. 11 (September 15, 2022): 1229–53.
Laurent, Camille, Charlotte Syrykh, Maxime Hamon, José Adélaïde, Arnaud Guille, Frederic Escudié, Gael Jalowicki, et al. “Resistance of B-Cell Lymphomas to CAR T-Cell Therapy Is Associated With Genomic Tumor Changes Which Can Result in Transdifferentiation.” The American Journal of Surgical Pathology 46, no. 6 (June 1, 2022): 742–53.
Reshma, Ismat Ara, Camille Franchet, Margot Gaspard, Radu Tudor Ionescu, Josiane Mothe, Sylvain Cussat-Blanc, Hervé Luga, and Pierre Brousset. “Finding a Suitable Class Distribution for Building Histological Images Datasets Used in Deep Model Training-The Case of Cancer Detection.” Journal of Digital Imaging, April 20, 2022.
Degboé, Yannick, Rémy Poupot, and Mary Poupot. “Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer.” International Journal of Molecular Sciences 23, no. 3 (January 28, 2022): 1496.
Piedrafita, Alexis, François Vergez, Julie Belliere, Nais Prades, Magali Colombat, Antoine Huart, Jean-Baptiste Rieu, et al. “Spectrum of Kidney Disorders Associated with T-Cell Immunoclones.” Journal of Clinical Medicine 11, no. 3 (January 25, 2022): 604.
Bachy, Emmanuel, Vincent Camus, Catherine Thieblemont, David Sibon, René-Olivier Casasnovas, Loïc Ysebaert, Gandhi Damaj, et al. “Romidepsin Plus CHOP Versus CHOP in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Results of the Ro-CHOP Phase III Study (Conducted by LYSA).” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 40, no. 3 (January 20, 2022): 242–51.
Rossi, Cédric, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, et al. “Baseline SUVmax Is Related to Tumor Cell Proliferation and Patient Outcome in Follicular Lymphoma.” Haematologica 107, no. 1 (January 1, 2022): 221–30.
Trecourt, Alexis, Claire Mauduit, Vanessa Szablewski, Juliette Fontaine, Brigitte Balme, Marie Donzel, Camille Laurent, et al. “Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas: A Series of 22 Cases Expanding the Spectrum of Transdifferentiation.” The American Journal of Surgical Pathology 46, no. 1 (January 1, 2022): 58–70.
Domagala, Marcin, Loïc Ysebaert, Laetitia Ligat, Frederic Lopez, Jean-Jacques Fournié, Camille Laurent, and Mary Poupot. “IL-10 Rescues CLL Survival through Repolarization of Inflammatory Nurse-like Cells.” Cancers 14, no. 1 (December 21, 2021): 16.
Lapierre, Leopoldine, Sarah Pericart, Caroline Protin, Cecile Borel, Loic Ysebaert, Camille Laurent, and Lucie Oberic. “Nivolumab in Refractory Cerebral Relapse of Hodgkin’s Lymphoma.” Leukemia & Lymphoma 62, no. 12 (December 2021): 3063–65.
Syrykh, Charlotte, Pauline Gorez, Sarah Péricart, David Grand, Frédéric Escudié, Bastien Cabarrou, Lucie Obéric, et al. “Molecular Diagnosis of T-Cell Lymphoma: A Correlative Study of PCR-Based T-Cell Clonality Assessment and Targeted NGS.” Blood Advances 5, no. 22 (November 23, 2021): 4590–93.
Cerapio, Juan Pablo, Marion Perrier, Fréderic Pont, Marie Tosolini, Camille Laurent, Stéphane Bertani, and Jean-Jacques Fournie. “Single-Cell RNAseq Profiling of Human Γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease.” Viruses 13, no. 11 (November 3, 2021): 2212.
Caputo, Sandrine M., Lisa Golmard, Mélanie Léone, Francesca Damiola, Marine Guillaud-Bataille, Françoise Revillion, Etienne Rouleau, et al. “Classification of 101 BRCA1 and BRCA2 Variants of Uncertain Significance by Cosegregation Study: A Powerful Approach.” American Journal of Human Genetics 108, no. 10 (October 7, 2021): 1907–23.
Laurent, Camille, José Adélaïde, Arnaud Guille, Bruno Tesson, Elodie Gat, Solene Evrard, Frederic Escudié, et al. “High-Grade Follicular Lymphomas Exhibit Clinicopathologic, Cytogenetic, and Molecular Diversity Extending Beyond Grades 3A and 3B.” The American Journal of Surgical Pathology 45, no. 10 (October 1, 2021): 1324–36.
Oberic, Lucie, Faustine Delzor, Caroline Protin, Sophie Perriat, Camille Laurent, Anaïs Grand, Jean Marie Canonge, et al. “Brentuximab Vedotin in Real Life, a Seven Year Experience in Patients with Refractory/Relapsed CD30+ T Cell Lymphoma.” Journal of Oncology Pharmacy Practice: Official Publication of the International Society of Oncology Pharmacy Practitioners 27, no. 7 (October 2021): 1730–35.
Lavalée, Margot, Nicolas Curdy, Camille Laurent, Jean-Jacques Fournié, and Don-Marc Franchini. “Cancer Cell Adaptability: Turning Ribonucleoprotein Granules into Targets.” Trends in Cancer 7, no. 10 (October 2021): 902–15.
Polivka, Laura, Veronique Parietti, Julie Bruneau, Erinn Soucie, Marine Madrange, Elisa Bayard, Rachel Rignault, et al. “The Association of Greig Syndrome and Mastocytosis Reveals the Involvement of Hedgehog Pathway in Advanced Mastocytosis.” Blood, August 23, 2021, blood.2020010207.
Franchet, Camille, Lounes Djerroudi, Aurélie Maran-Gonzalez, Olivia Abramovici, Martine Antoine, Véronique Becette, Anca Berghian, et al. “[2021 update of the GEFPICS’ recommendations for HER2 status assessment in invasive breast cancer in France].” Annales De Pathologie, August 12, 2021, S0242-6498(21)00191-7.
Bezombes, Christine, and Patricia Pérez-Galán. “Immunotherapies in Non-Hodgkin’s Lymphoma.” Cancers 13, no. 14 (July 20, 2021): 3625.
Syrykh, Charlotte, Sarah Péricart, Claire Lamaison, Frédéric Escudié, Pierre Brousset, and Camille Laurent. “Epstein-Barr Virus-Associated T- and NK-Cell Lymphoproliferative Diseases: A Review of Clinical and Pathological Features.” Cancers 13, no. 13 (July 1, 2021): 3315.
Laplagne, Chloé, Laetitia Ligat, Juliet Foote, Frederic Lopez, Jean-Jacques Fournié, Camille Laurent, Salvatore Valitutti, and Mary Poupot. “Self-Activation of Vγ9Vδ2 T Cells by Exogenous Phosphoantigens Involves TCR and Butyrophilins.” Cellular & Molecular Immunology, June 28, 2021.
Stuani, Lucille, Marie Sabatier, Estelle Saland, Guillaume Cognet, Nathalie Poupin, Claudie Bosc, Florence A. Castelli, et al. “Mitochondrial Metabolism Supports Resistance to IDH Mutant Inhibitors in Acute Myeloid Leukemia.” The Journal of Experimental Medicine 218, no. 5 (May 3, 2021).
Guigay, Joël, Anne Aupérin, Jérôme Fayette, Esma Saada-Bouzid, Cédrik Lafond, Miren Taberna, Lionnel Geoffrois, et al. “Cetuximab, Docetaxel, and Cisplatin versus Platinum, Fluorouracil, and Cetuximab as First-Line Treatment in Patients with Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma (GORTEC 2014-01 TPExtreme): A Multicentre, Open-Label, Randomised, Phase 2 Trial.” The Lancet. Oncology 22, no. 4 (April 2021): 463–75.
Evrard, Camille, Christophe Louvet, Farid El Hajbi, Frédéric DI Fiore, Karine LE Malicot, Thomas Aparicio, Olivier Bouché, et al. “PRODIGE 59-DURIGAST Trial: A Randomised Phase II Study Evaluating FOLFIRI + Durvalumab ± Tremelimumab in Second-Line of Patients with Advanced Gastric Cancer.” Digestive and Liver Disease: Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 53, no. 4 (April 2021): 420–26.
Syrykh, Charlotte, Loïc Ysebaert, Sarah Péricart, Solène M. Evrard, Fabienne Meggetto, Salim Kanoun, Pierre Brousset, and Camille Laurent. “ALK-Positive Histiocytosis Associated with Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma: A Multitarget Response under Ibrutinib.” Virchows Archiv: An International Journal of Pathology 478, no. 4 (April 2021): 779–83.
Bommier, Côme, Claire Mauduit, Juliette Fontaine, Estelle Bourbon, Pierre Sujobert, Sarah Huet, Lucile Baseggio, et al. “Real-Life Targeted next-Generation Sequencing for Lymphoma Diagnosis over 1 Year from the French Lymphoma Network.” British Journal of Haematology, March 25, 2021.
Gava, Fabien, Carla Faria, Pauline Gravelle, Juan G. Valero, Cèlia Dobaño-López, Renaud Morin, Marine Norlund, et al. “3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma.” Cancers 13, no. 7 (March 24, 2021).
Cerapio, Juan Pablo, Agnès Marchio, Luis Cano, Ignacio López, Jean-Jacques Fournié, Béatrice Régnault, Sandro Casavilca-Zambrano, et al. “Global DNA Hypermethylation Pattern and Unique Gene Expression Signature in Liver Cancer from Patients with Indigenous American Ancestry.” Oncotarget 12, no. 5 (March 2, 2021): 475–92.
Ghesquières, Hervé, Cédric Rossi, Fanny Cherblanc, Sandra Le Guyader-Peyrou, Fontanet Bijou, Pierre Sujobert, Pascale Fabbro-Peray, et al. “A French Multicentric Prospective Prognostic Cohort with Epidemiological, Clinical, Biological and Treatment Information to Improve Knowledge on Lymphoma Patients: Study Protocol of the ‘REal World DAta in LYmphoma and Survival in Adults’ (REALYSA) Cohort.” BMC Public Health 21, no. 1 (March 2, 2021): 432.
Poupot, Mary. “Why Target Innate Immune Cells in Cancers?” Cancers 13, no. 4 (February 9, 2021).
Curdy, Nicolas, Olivia Lanvin, Sarah Cadot, Camille Laurent, Jean-Jacques Fournié, and Don-Marc Franchini. “Stress Granules in the Post-Transcriptional Regulation of Immune Cells.” Frontiers in Cell and Developmental Biology 8 (February 2, 2021): 611185.
Burlet, Bénédicte, Selim Ramla, Cyril Fournier, Maria Jimena Abrey-Recalde, Camille Sauter, Marie-Lorraine Chrétien, Cédric Rossi, et al. “Identification of Novel, Clonally Stable, Somatic Mutations Targeting Transcription Factors PAX5 and NKX2-3, the Epigenetic Regulator LRIF1, and BRAF in a Case of Atypical B-Cell Chronic Lymphocytic Leukemia Harboring a t(14;18)(Q32;Q21).” Cold Spring Harbor Molecular Case Studies 7, no. 1 (February 2021).
Quelen, Cathy, David Grand, Emeline Sarot, Laurence Brugières, David Sibon, Anne Pradines, Camille Laurent, Pierre Brousset, and Laurence Lamant. “Minimal Residual Disease Monitoring Using a 3’ALK Universal Probe Assay in ALK-Positive Anaplastic Large-Cell Lymphoma: DdPCR, an Attractive Alternative Method to Real-Time Quantitative PCR.” The Journal of Molecular Diagnostics: JMD 23, no. 2 (February 2021): 131–39.
Domagala, Marcin, Chloé Laplagne, Edouard Leveque, Camille Laurent, Jean-Jacques Fournié, Eric Espinosa, and Mary Poupot. “Cancer Cells Resistance Shaping by Tumor Infiltrating Myeloid Cells.” Cancers 13, no. 2 (January 6, 2021).
Cerapio, Juan-Pablo, Marion Perrier, Camille-Charlotte Balança, Pauline Gravelle, Fréderic Pont, Christel Devaud, Don-Marc Franchini, et al. “Phased Differentiation of Γδ T and T CD8 Tumor-Infiltrating Lymphocytes Revealed by Single-Cell Transcriptomics of Human Cancers.” Oncoimmunology 10, no. 1 (2021): 1939518.
Ysebaert, Loic, Anne Quillet-Mary, Marie Tosolini, Frederic Pont, Camille Laurent, and Jean-Jacques Fournié. “Lymphoma Heterogeneity Unraveled by Single-Cell Transcriptomics.” Frontiers in Immunology 12 (2021): 597651.
Balança, Camille-Charlotte, Anna Salvioni, Clara-Maria Scarlata, Marie Michelas, Carlos Martinez-Gomez, Carlos Gomez-Roca, Victor Sarradin, et al. “PD-1 Blockade Restores Helper Activity of Tumor-Infiltrating Exhausted PD-1hiCD39+ CD4 T Cells.” JCI Insight, December 17, 2020.
Marku, Malvina, Nina Verstraete, Flavien Raynal, Miguel Madrid-Mencía, Marcin Domagala, Jean-Jacques Fournié, Loïc Ysebaert, Mary Poupot, and Vera Pancaldi. “Insights on TAM Formation from a Boolean Model of Macrophage Polarization Based on In Vitro Studies.” Cancers 12, no. 12 (December 7, 2020): 3664.
Gauthier, Martin, Jean-Baptiste Rieu, Camille Laurent, and François Vergez. “Eye-Catching Spindle-Shaped Mast Cells without Sinister Significance.” British Journal of Haematology, November 21, 2020.
Mouchel, Pierre‐Luc, Charlotte Syrykh, Camille Laurent, Suzanne Tavitian, and Martin Gauthier. “First Case of Classical Hodgkin‐like EBV ‐positive Lymphoproliferative Disorder under Ruxolitinib Therapy.” American Journal of Hematology, November 6, 2020, ajh.26026.
Bordes, Julien, Sébastien Incerti, Erick Mora-Ramirez, Jonathan Tranel, Cédric Rossi, Christine Bezombes, Julie Bordenave, Manuel Bardiès, Richard Brown, and Marie-Claude Bordage. “Monte Carlo Dosimetry of a Realistic Multicellular Model of Follicular Lymphoma in a Context of Radioimmunotherapy.” Medical Physics 47, no. 10 (October 2020): 5222–34.
Sarkozy, Clementine, Stacy S. Hung, Elizabeth A. Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C. Chong, Tomohiro Aoki, et al. “Mutational Landscape of Grey Zone Lymphoma.” Blood, September 22, 2020, blood.2020007507.
Gallais, Fanny, Loïc Ysebaert, Fabien Despas, Sandra De Barros, Loïc Dupré, Anne Quillet-Mary, Caroline Protin, et al. “Population Pharmacokinetics of Ibrutinib and Its Dihydrodiol Metabolite in Patients with Lymphoid Malignancies.” Clinical Pharmacokinetics 59, no. 9 (September 2020): 1171–83.
Jacquier, Anthony, Charlotte Syrykh, Isabelle Bedgedjian, Franck Monnien, Camille Laurent, Séverine Valmary-Degano, and Pierre Brousset. “Immunohistochemistry with Anti-MAL Antibody and RNAscope with MAL Probes Are Complementary Techniques for Diagnosis of Primary Mediastinal Large B-Cell Lymphoma.” Journal of Clinical Pathology, August 24, 2020, jclinpath-2020-206747.
Barré, Tangui, Marie Libérée Nishimwe, Camelia Protopopescu, Fabienne Marcellin, Fabrice Carrat, Céline Dorival, Elisabeth Delarocque‐Astagneau, et al. “Cannabis Use Is Associated with a Lower Risk of Diabetes in Chronic Hepatitis C‐infected Patients (ANRS CO22 Hepather Cohort).” Journal of Viral Hepatitis, August 18, 2020, jvh.13380.
Tan, Boun Kim, Mathieu Chalouni, Dominique Salmon Ceron, Alexandre Cinaud, Laure Esterle, Marc Arthur Loko, Christine Katlama, et al. “Atherosclerotic Cardiovascular Events in Patients Infected With Human Immunodeficiency Virus and Hepatitis C Virus.” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, July 20, 2020.
Zamò, Alberto, Peter Johnston, Ayoma D Attygalle, Camille Laurent, Daniel A Arber, and Falko Fend. “Aggressive B‐cell Lymphomas with a Primary Bone Marrow Presentation.” Histopathology, July 14, 2020, his.14124.
Aroua, Nesrine, Emeline Boet, Margherita Ghisi, Marie-Laure Nicolau-Travers, Estelle Saland, Ryan Gwilliam, Fabienne de Toni, et al. “Extracellular ATP and CD39 Activate CAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia.” Cancer Discovery, July 8, 2020, CD-19-1008.
Laplagne, Chloé, Sarah Meddour, Sarah Figarol, Marie Michelas, Olivier Calvayrac, Gilles Favre, Camille Laurent, Jean-Jacques Fournié, Stéphanie Cabantous, and Mary Poupot. “Vγ9Vδ2 T Cells Activation Through Phosphoantigens Can Be Impaired by a RHOB Rerouting in Lung Cancer.” Frontiers in Immunology 11 (July 7, 2020): 1396.
Dupin, Clairelyne, Drifa Belhadi, Laurent Guilleminault, Anne-Sophie Gamez, Patrick Berger, Frédéric De Blay, Philippe Bonniaud, et al. “Effectiveness and Safety of Dupilumab for the Treatment of Severe Asthma in a Real-Life French Multi-Centre Adult Cohort.” Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 50, no. 7 (July 2020): 789–98.
Balança, Camille-Charlotte, Clara-Maria Scarlata, Marie Michelas, Christel Devaud, Victor Sarradin, Camille Franchet, Carlos Martinez Gomez, et al. “Dual Relief of T-Lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies.” Cancer Immunology Research 8, no. 7 (July 2020): 869–82.
Attygalle, Ayoma D., Alberto Zamò, Falko Fend, Peter Johnston, Daniel A. Arber, and Camille Laurent. “Challenges and Limitations in the Primary Diagnosis of T-Cell and Natural Killer Cell/T-Cell Lymphoma in Bone Marrow Biopsy.” Histopathology 77, no. 1 (July 2020): 2–17.
Sarkozy, Clémentine, Lauren Chong, Katsuyoshi Takata, Elizabeth A. Chavez, Tomoko Miyata-Takata, Gerben Duns, Adèle Telenius, et al. “Gene Expression Profiling of Gray Zone Lymphoma.” Blood Advances 4, no. 11 (June 9, 2020): 2523–35.
Pont, Frédéric, Marie Tosolini, Qing Gao, Marion Perrier, Miguel Madrid-Mencía, Tse Shun Huang, Pierre Neuvial, Maha Ayyoub, Kristopher Nazor, and Jean-Jacques Fournié. “Single-Cell Virtual Cytometer Allows User-Friendly and Versatile Analysis and Visualization of Multimodal Single Cell RNAseq Datasets.” NAR Genomics and Bioinformatics 2, no. 2 (June 1, 2020): lqaa025.
Mescam, Lénaïg, Vincent Camus, Jean-Marc Schiano, José Adélaïde, Jean-Michel Picquenot, Arnaud Guille, Marie Bannier, et al. “EBV+ Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation Expands the Spectrum of Breast Implant-Related Lymphomas.” Blood 135, no. 22 (May 28, 2020): 2004–9.
Péricart, Sarah, Charlotte Syrykh, Nadia Amara, Camille Franchet, Bernard Malavaud, Philippe Gaulard, Jean-Philippe Girard, Loic Ysebaert, Camille Laurent, and Pierre Brousset. “Exclusive B-Cell Phenotype of Primary Prostatic Lymphomas: A Potential Role of Chronic Prostatitis.” Histopathology 76, no. 5 (April 2020): 767–73.
Aussedat, Guillaume, Alexandra Traverse-Glehen, Aspasia Stamatoullas, Thierry Molina, Violaine Safar, Camille Laurent, Jean-Marie Michot, et al. “Composite and Sequential Lymphoma between Classical Hodgkin Lymphoma and Primary Mediastinal Lymphoma/Diffuse Large B-Cell Lymphoma, a Clinico-Pathological Series of 25 Cases.” British Journal of Haematology 189, no. 2 (April 2020): 244–56.
Vidal-Crespo, Anna, Alba Matas-Céspedes, Vanina Rodriguez, Cédric Rossi, Juan G. Valero, Neus Serrat, Alejandra Sanjuan-Pla, et al. “Daratumumab Displays in Vitro and in Vivo Anti-Tumor Activity in Models of B-Cell Non-Hodgkin Lymphoma and Improves Responses to Standard Chemo-Immunotherapy Regimens.” Haematologica 105, no. 4 (April 2020): 1032–41.
Camille, Claire, Chloé Dimeglio, Antoine Yrondi, Gisèle Compaci, Emmanuelle Delmas, Mélanie Gauché, Guy Laurent, and Philippe Birmes. “Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study.” Frontiers in Psychiatry 11 (March 11, 2020): 201.
Laurent, Camille, Alina Nicolae, Cécile Laurent, Fabien Le Bras, Corinne Haioun, Virginie Fataccioli, Nadia Amara, et al. “Gene Alterations in Epigenetic Modifiers and JAK-STAT Signaling Are Frequent in Breast Implant-Associated ALCL.” Blood 135, no. 5 (January 30, 2020): 360–70.
Roussel, Mikael, Faustine Lhomme, Caroline E. Roe, Todd Bartkowiak, Pauline Gravelle, Camille Laurent, Thierry Fest, and Jonathan M. Irish. “Mass Cytometry Defines Distinct Immune Profile in Germinal Center B-Cell Lymphomas.” Cancer Immunology, Immunotherapy: CII, January 9, 2020.
Lièvre, Astrid, Anthony Turpin, Isabelle Ray-Coquard, Karine Le Malicot, Juliette Thariat, Guido Ahle, Cindy Neuzillet, et al. “Risk Factors for Coronavirus Disease 2019 (COVID-19) Severity and Mortality among Solid Cancer Patients and Impact of the Disease on Anticancer Treatment: A French Nationwide Cohort Study (GCO-002 CACOVID-19).” European Journal of Cancer 141 (2020): 62–81.
Cadot, Sarah, Carine Valle, Marie Tosolini, Frederic Pont, Laetitia Largeaud, Camille Laurent, Jean Jacques Fournie, Loic Ysebaert, and Anne Quillet-Mary. “Longitudinal CITE-Seq Profiling of Chronic Lymphocytic Leukemia during Ibrutinib Treatment: Evolution of Leukemic and Immune Cells at Relapse.” Biomarker Research 8, no. 1 (2020): 72.
Syrykh, Charlotte, Arnaud Abreu, Nadia Amara, Aurore Siegfried, Véronique Maisongrosse, François X. Frenois, Laurent Martin, Cédric Rossi, Camille Laurent, and Pierre Brousset. “Accurate Diagnosis of Lymphoma on Whole-Slide Histopathology Images Using Deep Learning.” Npj Digital Medicine 3, no. 1 (2020): 63.
El Halabi, Layal, Julien Adam, Pauline Gravelle, Virginie Marty, Alina Danu, Julien Lazarovici, Vincent Ribrag, et al. “Expression of the Immune Checkpoint Regulators LAG-3 and TIM-3 in Classical Hodgkin Lymphoma.” Clinical Lymphoma Myeloma and Leukemia, 2020, S2152265020306339.
Vallet-Pichard, Anais, Jean-Michel Correas, Celine Dorival, Fabien Zoulim, Albert Tran, Marc Bourlière, Paul Calès, et al. “Absence of Impact of Direct Acting Antivirals for Hepatitis C Virus on Recurrent Hepatocellular Carcinoma Tumor Growth in the AFEF/ANRS CO22 Hepather Cohort.” Clinics and Research in Hepatology and Gastroenterology, 2020, S2210740120301522.
Laurent, Camille, Daniel A. Arber, Peter Johnston, Falko Fend, Alberto Zamo, and Ayoma D. Attygalle. “Diagnosis of Classic Hodgkin Lymphoma on Bone Marrow Biopsy.” Histopathology 76, no. 7 (2020): 934–41.
Brunac, Anne‐Cécile, Anne Laprie, Marie‐Pierre Castex, Camille Laurent, François Le Loarer, Marie Karanian, Sophie Le Guellec, Delphine Guillemot, Gaelle Pierron, and Anne Gomez‐Brouchet. “The Combination of Radiotherapy and ALK Inhibitors Is Effective in the Treatment of Intraosseous Rhabdomyosarcoma with FUS‐TFCP2 Fusion Transcript.” Pediatric Blood & Cancer 67, no. 5 (2020).
Egan, Caoimhe, Camille Laurent, Julie C. Alejo, Stefano Pileri, Elias Campo, Steven H. Swerdlow, Miguel Piris, et al. “Expansion of PD1-Positive T Cells in Nodal Marginal Zone Lymphoma: A Potential Diagnostic Pitfall.” The American Journal of Surgical Pathology 44, no. 5 (2020): 657–64.
Philippe, Laure, Remi Lancar, Camille Laurent, Michele Algarte‐Genin, Catherine Chassagne‐Clément, Bettina Fabiani, Marie Pierre Chenard, et al. “BCL2 Expression Is an Independent Prognostic Factor in HIV‐associated DLBCL, a LYMPHOVIR Cohort Study.” British Journal of Haematology 188, no. 3 (2020): 413–23.
Zamora, Audrey, Melinda Alves, Charlotte Chollet, Nicole Therville, Tiffany Fougeray, Florence Tatin, Camille Franchet, et al. “Paclitaxel Induces Lymphatic Endothelial Cells Autophagy to Promote Metastasis.” Cell Death & Disease 10, no. 12 (December 20, 2019): 956.
Péricart, Sarah, Charlotte Waysse, Aurore Siegfried, Stephanie Struski, Eric Delabesse, Camille Laurent, and Solène Evrard. “Subsequent Development of Histiocytic Sarcoma and Follicular Lymphoma: Cytogenetics and next-Generation Sequencing Analyses Provide Evidence for Transdifferentiation of Early Common Lymphoid Precursor-a Case Report and Review of Literature.” Virchows Archiv: An International Journal of Pathology, December 5, 2019.
Piau, Antoine, Gilles Bourgade, Caroline Berbon, Fati Nourhashemi, Camille Louit, and Laurent Balardy. “Access to Individualized Oncology Care for Older Patients in Complex Healthcare Networks: The Skilled Nurse Option.” Journal of Geriatric Oncology, November 15, 2019.
Sarkozy, Clementine, Stacy Hung, Katsuyoshi Takata, Elizabeth Chavez, Tomohiro Aoki, Gerben Duns, Graham W. Slack, et al. “Mutational Landscape of Grey Zone Lymphoma.” Blood 134, no. Supplement_1 (November 13, 2019): 21.
Laplagne, Chloé, Marcin Domagala, Augustin Le Naour, Christophe Quemerais, Dimitri Hamel, Jean-Jacques Fournié, Bettina Couderc, Corinne Bousquet, Audrey Ferrand, and Mary Poupot. “Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression.” International Journal of Molecular Sciences 20, no. 19 (September 23, 2019).
Mondragón, Laura, Rana Mhaidly, Gian Marco De Donatis, Marie Tosolini, Pascal Dao, Anthony R. Martin, Caroline Pons, et al. “GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-ΚB-Dependent Mechanism.” Cancer Cell, August 20, 2019.
Gauthier, Martin, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary, and Loic Ysebaert. “Prognostic Role of CD4 T-Cell Depletion after Frontline Fludarabine, Cyclophosphamide and Rituximab in Chronic Lymphocytic Leukaemia.” BMC Cancer 19, no. 1 (August 14, 2019): 809.
Laurent, Camille, and Pierre Brousset. “[New entities and new tools in hematopathology as proposed by the 2016 WHO classification: Case 7].” Annales De Pathologie, August 9, 2019.
Laurent, Camille, and Pierre Brousset. “[New entities and new tools in hematopathology as proposed by the 2016 WHO classification: Case 6].” Annales De Pathologie, August 9, 2019.
Le Loarer, François, Arjen H. G. Cleven, Corinne Bouvier, Marie-Pierre Castex, Cleofe Romagosa, Anne Moreau, Sébastien Salas, et al. “A Subset of Epithelioid and Spindle Cell Rhabdomyosarcomas Is Associated with TFCP2 Fusions and Common ALK Upregulation.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, August 5, 2019.
Branco, Benoît, Thibault Comont, Loïc Ysebaert, Muriel Picard, Camille Laurent, and Lucie Oberic. “Targeted Therapy of BRAF V600E-Mutant Histiocytic Sarcoma: A Case Report and Review of the Literature.” European Journal of Haematology, August 2, 2019.
Curdy, Nicolas, Olivia Lanvin, Camille Laurent, Jean-Jacques Fournié, and Don-Marc Franchini. “Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptors Expression.” Trends in Cell Biology, August 1, 2019.
Franchini, Don-Marc, Olivia Lanvin, Nicolas Curdy, and Jean-Jacques Fournié. “[Control of lymphocyte activity by stress granules. New targets for immunotherapy ?].” Medecine Sciences: M/S 35, no. 6–7 (July 2019): 507–9.
Maran-Gonzalez, Aurélie, Camille Franchet, Raphaëlle Duprez-Paumier, Martine Antoine, Catherine Barlier, Véronique Becette, Anca Berghian, et al. “[GEFPICS’ guidelines for management of breast cancer tissue samples in the neoadjuvant setting].” Annales De Pathologie, June 27, 2019.
Flinn, Ian W., John G. Gribben, Martin J. S. Dyer, William Wierda, Michael B. Maris, Richard R. Furman, Peter Hillmen, et al. “Phase 1b Study of Venetoclax-Obinutuzumab in Previously Untreated and Relapsed/Refractory Chronic Lymphocytic Leukemia.” Blood 133, no. 26 (June 27, 2019): 2765–75.
Vaysse, Charlotte, Camille Laurent, Loïc Ysebaert, Elodie Chantalat, and Benoit Chaput. “France: The First Country to Ban a Type of Breast Implant Linked to Anaplastic Large Cell Lymphoma.” Aesthetic Surgery Journal, June 1, 2019.
Pizzolato, Gabriele, Hannah Kaminski, Marie Tosolini, Don-Marc Franchini, Fréderic Pont, Fréderic Martins, Carine Valle, et al. “Single-Cell RNA Sequencing Unveils the Shared and the Distinct Cytotoxic Hallmarks of Human TCRVδ1 and TCRVδ2 Γδ T Lymphocytes.” Proceedings of the National Academy of Sciences of the United States of America, May 22, 2019.
Quintyn, Jean-Claude, Priscille Olle, Monique Courtade-Saidi, Camille Laurent, Lucie Obéric, and Marie-Laure Quintyn-Ranty. “Cytological Diagnosis of Vitreoretinal Lymphomas: A Case Series.” Cytopathology: Official Journal of the British Society for Clinical Cytology, April 29, 2019.
Guinard, Elisabeth, Fawaz Alenezi, Laurence Lamant, Vanessa Szablewski, Emilie Tournier, Camille Laurent, Carle Paul, Nicolas Meyer, Olivier Dereure, and Serge Boulinguez. “Staging of Primary Cutaneous Follicle Centre B-Cell Lymphoma: Bone Marrow Biopsy, CD10, BCL2 and t(14;18) Are Not Relevant Prognostic Factors.” European Journal of Dermatology: EJD, April 17, 2019.
Perchey, Renaud T., Laure Tonini, Marie Tosolini, Jean-Jacques Fournié, Frédéric Lopez, Arnaud Besson, and Frédéric Pont. “PTMselect: Optimization of Protein Modifications Discovery by Mass Spectrometry.” Scientific Reports 9, no. 1 (March 12, 2019): 4181.
Sarkozy, Clémentine, Christiane Copie-Bergman, Diane Damotte, Susana Ben-Neriah, Barbara Burroni, Jérome Cornillon, Richard Lemal, et al. “Gray-Zone Lymphoma Between CHL and Large B-Cell Lymphoma: A Histopathologic Series From the LYSA.” The American Journal of Surgical Pathology 43, no. 3 (March 2019): 341–51.
Baseggio, Lucile, Alexandra Travers-Glehen, Emmanuel Bachy, and Camille Laurent. “Breast Implant-Associated Anaplastic Large Cell Lymphoma.” Blood Research 54, no. 1 (March 2019): 3.
Phonesouk, Erick, Séverine Lechevallier, Audrey Ferrand, Marie-Pierre Rols, Christine Bezombes, Marc Verelst, and Muriel Golzio. “Increasing Uptake of Silica Nanoparticles with Electroporation: From Cellular Characterization to Potential Applications.” Materials (Basel, Switzerland) 12, no. 1 (January 7, 2019): E179.
Alaeddine, Mohamad, Mélissa Prat, Véréna Hauke Poinsot, Valérie Gouazé-Andersson, Hélène Authier, Etienne Meunier, Lise Lefèvre, et al. “IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells.” Cancer Immunology Research, January 4, 2019.
Laurent, Victor, Aurélie Toulet, Camille Attané, Delphine Milhas, Stéphanie Dauvillier, Falek Zaidi, Emily Clement, et al. “Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity- Dependent Manner: Role of Oxidative Stress.” Molecular Cancer Research: MCR, January 3, 2019.
Franchini, Don-Marc, Olivia Lanvin, Marie Tosolini, Emilie Patras de Campaigno, Anne Cammas, Sarah Péricart, Clara-Maria Scarlata, et al. “Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.” Cell Reports 26, no. 1 (January 2, 2019): 94-107.e7.
Croce, Sabrina, Tom Lesluyes, Lucile Delespaul, Benjamin Bonhomme, Gaëlle Pérot, Valérie Velasco, Laetitia Mayeur, et al. “GREB1-CTNNB1 Fusion Transcript Detected by RNA-Sequencing in a Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Novel CTNNB1 Rearrangement.” Genes, Chromosomes & Cancer 58, no. 3 (2019): 155–63.
Decaup, Emilie, Cédric Rossi, Pauline Gravelle, Camille Laurent, Julie Bordenave, Marie Tosolini, Anne Tourette, et al. “A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma.” Frontiers in Immunology 10 (2019): 1943.
Rossi, Cédric, Pauline Gravelle, Emilie Decaup, Julie Bordenave, Mary Poupot, Marie Tosolini, Don-Marc Franchini, et al. “Boosting Γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity by PD-1 Blockade in Follicular Lymphoma.” Oncoimmunology 8, no. 3 (2019): 1554175.

team members

Sonia Quertinmont
Ingénieur de laboratoire / laboratory engineer
Marie Tosolini
Ingénieur de laboratoire / laboratory engineer
Amandine Prioux-Quartier
Ingénieur de laboratoire / laboratory engineer
Nicolas Gower
Master / Master student
Marion Lenerz
Master / Master student
Léa Rimailho
Doctorant / PhD student
Doctorant / PhD student
Nicolas Curdy
Doctorant / PhD student
Annie Alloy
Technicien de laboratoire / Laboratory Technician
Fabien Gava
Chercheur Post-Doctorant / Post-Doc researcher
Carla Faria
Doctorant / PhD student
Hospitalo-Universitaire / University teacher hospital practitioner
Cathy Quelen
Ingénieur de laboratoire / laboratory engineer
christine Bezombes
Chercheur statutaire / permanent scientist
Anne Quillet-Mary
Chercheur statutaire / permanent scientist
Don-Marc Franchini
Chercheur Post-Doctorant / Post-Doc researcher
Olivia Lanvin
Ingénieur de laboratoire / laboratory engineer
Mary Poupot
Chercheur statutaire / permanent scientist
Pauline Gravelle
Ingénieur de laboratoire / laboratory engineer

parternships & funding

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse – FR

Nous contacter

05 82 74 15 75

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