Molecular dynamics of Lymphocyte Interactions
The team is part of the ERC Synergy Grant funded “ATTACK Cancer” consortium, aiming to develop more effective and targeted cancer treatments.
The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer.
OUR RESEARCH AXIS
Immune responses are based on multiple and dynamic interactions between cells of the immune system leading to the formation of specialized signaling areas, the immunological synapses.
Our team applies a combination of state-of-the-art approaches, including fast live cell imaging and super-resolution microscopy (on single cells and human tissue slices) as well as mathematical modeling, in order to visualize and interpret the molecular dynamics occurring at immunological synapses. Deciphering the intercellular communication at the level of immunological synapses may contribute to the design of innovative therapeutic strategies aimed at modulating immune responses in different pathological contexts. Our research develops along the following 4 main axes.
Cytotoxic T lymphocytes
Real-time imaging techniques
In silico modeling
Cartesian genetic programming
The struggle between cytotoxic t lymphocytes and tumor cells at the lytic synapse
Dr Salvatore Valitutti
Modeling and computer vision applied to the study of competitive ctl/target cell interactions
Salvatore Valitutti & Sylvain Cussat-Blanc
Function and regulation of tissue memory-resident cd8+ t cells
Study of target cell pyroptosis in the context of ctl-induced death
Dr Brienne Mckenzie
PARTNERSHIPS & FUNDING
Toulouse Cancer Research Center (Oncopole)
Toulouse - FR
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