DynAct :
Molecular dynamics of Lymphocyte Interactions


The team is part of the ERC Synergy Grant funded “ATTACK Cancer” consortium, aiming to develop more effective and targeted cancer treatments.

The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer.


Immune responses are based on multiple and dynamic interactions between cells of the immune system leading to the formation of specialized signaling areas, the immunological synapses.

Our team applies a combination of state-of-the-art approaches, including fast live cell imaging and super-resolution microscopy (on single cells and human tissue slices) as well as mathematical modeling, in order to visualize and interpret the molecular dynamics occurring at immunological synapses. Deciphering the intercellular communication at the level of immunological synapses may contribute to the design of innovative therapeutic strategies aimed at modulating immune responses in different pathological contexts. Our research develops along the following 4 main axes.


Immunological synapse

Cytotoxic T lymphocytes

Tumor immunology

Real-time imaging techniques

Tumor immunoevasion


Computational biology

In silico modeling

Computer vision

Cartesian genetic programming

CD8+ memory-resident
T cells

     Tumor microenvironment


scientific productions

Laplagne, Chloé, Laetitia Ligat, Juliet Foote, Frederic Lopez, Jean-Jacques Fournié, Camille Laurent, Salvatore Valitutti, and Mary Poupot. “Self-Activation of Vγ9Vδ2 T Cells by Exogenous Phosphoantigens Involves TCR and Butyrophilins.” Cellular & Molecular Immunology, June 28, 2021.
Lafouresse, Fanny, Romain Jugele, Sabina Müller, Marine Doineau, Valérie Duplan-Eche, Eric Espinosa, Marie-Pierre Puisségur, Sébastien Gadat, and Salvatore Valitutti. “Stochastic Asymmetric Repartition of Lytic Machinery in Dividing CD8+ T Cells Generates Heterogeneous Killing Behavior.” ELife 10 (January 11, 2021).
Bálint, š., S. Müller, R. Fischer, B. M. Kessler, M. Harkiolaki, S. Valitutti, and M. L. Dustin. “Supramolecular Attack Particles Are Autonomous Killing Entities Released from Cytotoxic T Cells.” Science 368, no. 6493 (May 22, 2020): 897–901.
Biolato, Andrea Michela, Liza Filali, Hannah Wurzer, Céline Hoffmann, Ernesto Gargiulo, Salvatore Valitutti, and Clément Thomas. “Actin Remodeling and Vesicular Trafficking at the Tumor Cell Side of the Immunological Synapse Direct Evasion from Cytotoxic Lymphocytes.” In International Review of Cell and Molecular Biology, 356:99–130. Elsevier, 2020.
Khazen, Roxana, Sabina Müller, Fanny Lafouresse, Salvatore Valitutti, and Sylvain Cussat-Blanc. “Sequential Adjustment of Cytotoxic T Lymphocyte Densities Improves Efficacy in Controlling Tumor Growth.” Scientific Reports 9, no. 1 (August 23, 2019): 12308.
Cordella, Martina, Claudio Tabolacci, Cinzia Senatore, Stefania Rossi, Sabina Mueller, Carla Lintas, Adriana Eramo, et al. “Theophylline Induces Differentiation and Modulates Cytoskeleton Dynamics and Cytokines Secretion in Human Melanoma-Initiating Cells.” Life Sciences 230 (August 1, 2019): 121–31.
Gonnord, Pauline, Manon Costa, Arnaud Abreu, Michael Peres, Loïc Ysebaert, Sébastien Gadat, and Salvatore Valitutti. “Multiparametric Analysis of CD8+ T Cell Compartment Phenotype in Chronic Lymphocytic Leukemia Reveals a Signature Associated with Progression toward Therapy.” Oncoimmunology 8, no. 4 (2019): e1570774.


Kévin Cortacero
Etudiant ou stagiaire / PhD student or Trainee
Salvatore Valitutti
Chercheur / Researcher
Chloé Lamesa
Personnel hospitalier / Hospital Staff
Cécile Demeur
Enseignant-chercheur / Teacher-researcher
Sabina Mueller
Ingénieur ou technicien / Engineer or Technician
Marie-Pierre Puisségur
Ingénieur ou technicien / Engineer or Technician
Brienne McKenzie
Chercheur / Researcher
Lucie Demeersseman
Ingénieur ou technicien / Engineer or Technician
Gaëlle Corsaut
Ingénieur ou technicien / Engineer or Technician
Frecia Rodriguez
Etudiant ou stagiaire / PhD student or Trainee
Fanny Lafouresse
Chercheur / Researcher


Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse – FR

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