TEAM
SALVATORE VALITUTTI

DynAct :
Molecular dynamics of Lymphocyte Interactions

 

The team is part of the ERC Synergy Grant funded “ATTACK Cancer” consortium, aiming to develop more effective and targeted cancer treatments.

The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer.

THE SPECIFITIES
OUR RESEARCH AXIS

Immune responses are based on multiple and dynamic interactions between cells of the immune system leading to the formation of specialized signaling areas, the immunological synapses.

Our team applies a combination of state-of-the-art approaches, including fast live cell imaging and super-resolution microscopy (on single cells and human tissue slices) as well as mathematical modeling, in order to visualize and interpret the molecular dynamics occurring at immunological synapses. Deciphering the intercellular communication at the level of immunological synapses may contribute to the design of innovative therapeutic strategies aimed at modulating immune responses in different pathological contexts. Our research develops along the following 4 main axes.

 

Immunological synapse

Cytotoxic T lymphocytes

Tumor immunology

Real-time imaging techniques

Tumor immunoevasion

Pyroptosis

Computational biology

In silico modeling

Computer vision

Cartesian genetic programming

CD8+ memory-resident
T cells

     Tumor microenvironment

RESEARCH PROJECTS

THE TEAM’S
FOCUS

scientific productions

PUBLICATIONS 2022
Leveque, Edouard, Axel Rouch, Charlotte Syrykh, Julien Mazières, Laurent Brouchet, Salvatore Valitutti, Eric Espinosa, and Fanny Lafouresse. “Phenotypic and Histological Distribution Analysis Identify Mast Cell Heterogeneity in Non-Small Cell Lung Cancer.” Cancers 14, no. 6 (March 9, 2022): 1394. https://doi.org/10.3390/cancers14061394.
Filali, Liza, Marie-Pierre Puissegur, Kevin Cortacero, Sylvain Cussat-Blanc, Roxana Khazen, Nathalie Van Acker, François-Xavier Frenois, et al. “Ultrarapid Lytic Granule Release from CTLs Activates Ca2+-Dependent Synaptic Resistance Pathways in Melanoma Cells.” Science Advances 8, no. 7 (February 18, 2022): eabk3234. https://doi.org/10.1126/sciadv.abk3234.
McKenzie, Brienne, Roxana Khazen, and Salvatore Valitutti. “Greek Fire, Poison Arrows, and Scorpion Bombs: How Tumor Cells Defend Against the Siege Weapons of Cytotoxic T Lymphocytes.” Frontiers in Immunology 13 (2022): 894306. https://doi.org/10.3389/fimmu.2022.894306.
PUBLICATIONS 2021
Laplagne, Chloé, Laetitia Ligat, Juliet Foote, Frederic Lopez, Jean-Jacques Fournié, Camille Laurent, Salvatore Valitutti, and Mary Poupot. “Self-Activation of Vγ9Vδ2 T Cells by Exogenous Phosphoantigens Involves TCR and Butyrophilins.” Cellular & Molecular Immunology, June 28, 2021. https://doi.org/10.1038/s41423-021-00720-w.
Lafouresse, Fanny, Romain Jugele, Sabina Müller, Marine Doineau, Valérie Duplan-Eche, Eric Espinosa, Marie-Pierre Puisségur, Sébastien Gadat, and Salvatore Valitutti. “Stochastic Asymmetric Repartition of Lytic Machinery in Dividing CD8+ T Cells Generates Heterogeneous Killing Behavior.” ELife 10 (January 11, 2021): e62691. https://doi.org/10.7554/eLife.62691.
PUBLICATIONS 2020
Bálint, š., S. Müller, R. Fischer, B. M. Kessler, M. Harkiolaki, S. Valitutti, and M. L. Dustin. “Supramolecular Attack Particles Are Autonomous Killing Entities Released from Cytotoxic T Cells.” Science 368, no. 6493 (May 22, 2020): 897–901. https://doi.org/10.1126/science.aay9207.
Biolato, Andrea Michela, Liza Filali, Hannah Wurzer, Céline Hoffmann, Ernesto Gargiulo, Salvatore Valitutti, and Clément Thomas. “Actin Remodeling and Vesicular Trafficking at the Tumor Cell Side of the Immunological Synapse Direct Evasion from Cytotoxic Lymphocytes.” In International Review of Cell and Molecular Biology, 356:99–130. Elsevier, 2020. https://doi.org/10.1016/bs.ircmb.2020.07.001.
PUBLICATIONS 2019
Khazen, Roxana, Sabina Müller, Fanny Lafouresse, Salvatore Valitutti, and Sylvain Cussat-Blanc. “Sequential Adjustment of Cytotoxic T Lymphocyte Densities Improves Efficacy in Controlling Tumor Growth.” Scientific Reports 9, no. 1 (August 23, 2019): 12308. https://doi.org/10.1038/s41598-019-48711-2.
Cordella, Martina, Claudio Tabolacci, Cinzia Senatore, Stefania Rossi, Sabina Mueller, Carla Lintas, Adriana Eramo, et al. “Theophylline Induces Differentiation and Modulates Cytoskeleton Dynamics and Cytokines Secretion in Human Melanoma-Initiating Cells.” Life Sciences 230 (August 1, 2019): 121–31. https://doi.org/10.1016/j.lfs.2019.05.050.
Gonnord, Pauline, Manon Costa, Arnaud Abreu, Michael Peres, Loïc Ysebaert, Sébastien Gadat, and Salvatore Valitutti. “Multiparametric Analysis of CD8+ T Cell Compartment Phenotype in Chronic Lymphocytic Leukemia Reveals a Signature Associated with Progression toward Therapy.” Oncoimmunology 8, no. 4 (2019): e1570774. https://doi.org/10.1080/2162402X.2019.1570774.

TEAM MEMBERS

 PARTNERSHIPS & FUNDING

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse – FR

Nous contacter

05 82 74 15 75

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