JOIN THE CRCT

Postdoctoral position (M/F; 1 yr, renewal 3 yrs)​

PROJECT

IRONAML53 – Uncovering and targeting metabolic vulnerabilities of acute myeloid leukemia harboring TP53 mutations, promoting Darwinian advantages in leukemic evolution and drug resistance

The postdoctoral fellow will be implicated in a highly collaborative project between the CRCT (JE Sarry,Toulouse), METATOUL (JC Portais, Toulouse), IRCM (L Le Cam, Montpellier) and Cochin (C Peysonneaux, Paris). The postdoctoral fellow will establish unique PDX models (well handled by the
CRCT) and novel GEMMs and will study cellular and metabolic mapping of TP53 mutant leukemic blasts and their microenvironment in those models. He/she will be devoted to unravel the role of host iron in the development of selective advantage and chemoresistance of distinct TP53 clones. Her/his work will be done in close collaboration with PhD students and engineers working on the multidisicplianry project. General responsibilities include design, implement and interpret experiments, both independently and in collaboration, and communicate research and findings in a clear and concise
manner. The postdoctoral fellow will present the progress of the project during bi-monthly meetings between the different teams, as well as during national and international conferences.

EMPLOYMENT

Starting beginning of 2023, the job position is funded by an INCA-HRHG grant.
The application should be written in English and include:
1. Letter of motivation with a short description of the applicant’s previous research and why
the applicant considers her/himself a good match for the position (1-2 pages).
2. Curriculum vitae, including a description of relevant skills and experiences, as well as a full
publication list.
3. Names, e-mail addresses and telephone numbers to 2-3 references.

CONTACT

Application should be sent to Jean-Emmanuel Sarry (jean-emmanuel.sarry@inserm.fr).

More information >>>

Deciphering the complexity of aggressive breast cancer to improve survival

The Cancer Research Center of Toulouse (CRCT, Inserm / CNRS / University Toulouse III Paul Sabatier ), together with the Fondation Toulouse Cancer Santé and the Institut Claudius Regaud are launching a call for projects to recruit a research team working in the field of Triple Negative Breast Cancer (TNBC).

Triple Negative Breast Cancer (TNBC) is a highly heterogeneous and clinically aggressive neoplasm that accounts for 15-20% of breast cancers with the highest mortality rate of all breast cancer subtypes.

TNBC is defined by a poorly differentiated state, lack of expression of the estrogen receptor (ER) or progesterone receptor (PR), and without overexpression/amplification of human HER2. Unlike hormone receptor-positive breast cancer, which is usually treated with hormonotherapy, or HER2-positive breast cancer, which can be treated with therapeutic antibodies (e.g. trastuzumab), TNBC management do not benefit so far from effective targeted therapy, and conventional chemotherapy remains the standard of care for patients with limited clinical impact. In addition, the molecular biology of this cancer type is still poorly understood. Therefore, a better understanding of TNBC oncogenesis and the identification of novel actionable targets could greatly benefit to patients with this disease.

The objective of this Chair is to better understand the genetics, biology and microenvironment of TNBC, based on innovative technologies such as single cell molecular analysis, as a source for novel targets and therapeutic strategies.

This Chair is aimed at world-class researchers. The laureate will receive funding equivalent to an ERC Starting Grant of €1.5 million for a period of 5 years. The terms of the funding will be negotiated with the winner.

This chair complies with the CRCT’s scientific priorities and will benefit from the support of IUCT-Oncopole’s clinical and bioclinical teams who are currently investigating the genomic landscape and the characteristics of metastatic TNBC. The successful applicant will conduct world-class research using state-of-the art technological platforms, shared between the CRCT and the IUCT-Oncopole, for the molecular exploration of patient tissues.

Applications must include :

• A non-confidential summary of the project for the general public (maximum 1 page, Calibri 10 font)
• The complete scientific project, including the scientific objectives of the project, the methodology and techniques, as well as the expected results (5 pages maximum excluding figures, Calibri 10 font).
• The complete CV of the applicant.
• The complete list of the applicant’s publications.
• A proposed budget.

The evaluation of the projects will be done on site by an international external jury in spring 2023, with an expected start in autumn 2023. The exact timetable will be communicated to applicants at a later date.

Applications should be sent before 1 December 2022 to sebastien.guibert@inserm.fr