Team
Pierre Cordelier

ImPact :

Therapeutic innovation in pancreatic cancer

The specificities
of our research axis

Pancreatic cancer, or pancreatic adenocarcinoma (PDAC), will soon become the second leading cause of cancer deaths worldwide, due to late diagnosis and lack of effective treatment. Our research effort is dedicated to the development of new strategies to improve the management of patients with this cancer.

In this context, our research objective is to better understand the mechanisms of PDAC oncogenesis and therapeutic resistance. In particular, we are studying the role of genome remodelling and replication in gene expression and resistance to DNA-breaking agents (Project 1). We are deciphering the proteins and protein-protein interactions involved in pancreatic oncogenesis and resistance to treatment using intracellular antibodies (Project 2). Finally, we are investigating the mechanisms responsible for the resistance of cancer cells to oncolytic viruses, and studying the impact of these viruses on the anti-tumour immune response (Project 3).

The overall goal of this research project is to translate our basic research findings into tangible therapeutic innovations for pancreatic cancer patients, using a precision medicine approach.

Pancreatic Cancer

Oncogenesis

Resistance

Innovative therapies

Regulation of gene expression

Protein-protein interaction

Intracellular antibodies

Oncolytic viruses

Gene therapy

Immunotherapy

interdisciplinarity

research
projects

Live

We developed an AI to recognize and quantify pancreatic cancer subtypes from histology.

Accurate for Basal-like/Classical and stroma Active/Inactive to classify whole tumors and local patterns

Paint histology by phenotypes:
PACpAInt
https://www.biorxiv.org/content/10.1101/2022.01.04.474951v1

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scientific productions

PUBLICATIONS 2022
PUBLICATIONS 2021
Marinho, Anthony, Nicolas Zalay, Léonor Chaltiel, Sylvain Kirzin, Antoine Philis, Jannick Selves, Nicolas Carrère, Etienne Buscail, and Laurent Ghouti. “Oncologic and Functional Outcomes of Pelvic Perineal Reconstruction by Perineal Colostomy and Malone Procedure After Abdominoperineal Resection.” Diseases of the Colon and Rectum 64, no. 12 (December 1, 2021): 1501–10. https://doi.org/10.1097/DCR.0000000000001941.
Sorbara, Marie, and Nicolas Bery. “Targeting Small GTPases and Their Downstream Pathways with Intracellular Macromolecule Binders to Define Alternative Therapeutic Strategies in Cancer.” Biochemical Society Transactions 49, no. 5 (November 1, 2021): 2021–35. https://doi.org/10.1042/BST20201059.
Thibault, Benoit, Fernanda Ramos-Delgado, Elvire Pons-Tostivint, Nicole Therville, Celia Cintas, Silvia Arcucci, Stephanie Cassant-Sourdy, et al. “Pancreatic Cancer Intrinsic PI3Kα Activity Accelerates Metastasis and Rewires Macrophage Component.” EMBO Molecular Medicine 13, no. 7 (July 7, 2021): e13502. https://doi.org/10.15252/emmm.202013502.
Montfort, Anne, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, et al. “Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.” Cancer Immunology Research 9, no. 5 (May 2021): 568–82. https://doi.org/10.1158/2326-6066.CIR-20-0342.
Tijunelyte, Inga, Rémi Malbec, Bayan Chami, Jean Cacheux, Christophe Dez, Thierry Leichlé, Pierre Cordelier, and Aurélien Bancaud. “Micro-RNA 21 Detection with a Limit of 2 PM in 1 Min Using a Size-Accordable Concentration Module Operated by Electrohydrodynamic Actuation.” Biosensors & Bioelectronics 178 (April 15, 2021): 112992. https://doi.org/10.1016/j.bios.2021.112992.
Quillien, Lorraine, Sokunthea Top, Sandrine Kappler-Gratias, Agathe Redouté, Nelson Dusetti, Charlotte Quentin-Froignant, Hubert Lulka, et al. “A Novel Imaging Approach for Single-Cell Real-Time Analysis of Oncolytic Virus Replication and Efficacy in Cancer Cells.” Human Gene Therapy 32, no. 3–4 (February 2021): 166–77. https://doi.org/10.1089/hum.2020.294.
PUBLICATIONS 2020
Frere, Corinne, Benjamin Crichi, Barbara Bournet, Cindy Canivet, Nassim Ait Abdallah, Louis Buscail, and Dominique Farge. “Primary Thromboprophylaxis in Ambulatory Pancreatic Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Cancers 12, no. 8 (July 24, 2020): 2028. https://doi.org/10.3390/cancers12082028.
Amintas, Samuel, Aurélie Bedel, François Moreau-Gaudry, Julian Boutin, Louis Buscail, Jean-Philippe Merlio, Véronique Vendrely, Sandrine Dabernat, and Etienne Buscail. “Circulating Tumor Cell Clusters: United We Stand Divided We Fall.” International Journal of Molecular Sciences 21, no. 7 (April 10, 2020): E2653. https://doi.org/10.3390/ijms21072653.
Maulat, Charlotte, Cindy Canivet, Célia Touraine, Sophie Gourgou, Bertrand Napoleon, Laurent Palazzo, Nicolas Flori, et al. “A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score.” Cancers 12, no. 4 (March 25, 2020): 783. https://doi.org/10.3390/cancers12040783.
Frances, Audrey, and Pierre Cordelier. “The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?” Molecular Therapy: The Journal of the American Society of Gene Therapy, February 5, 2020. https://doi.org/10.1016/j.ymthe.2019.11.026.
Buscail, Louis, Barbara Bournet, and Pierre Cordelier. “Role of Oncogenic KRAS in the Diagnosis, Prognosis and Treatment of Pancreatic Cancer.” Nature Reviews. Gastroenterology & Hepatology, January 31, 2020. https://doi.org/10.1038/s41575-019-0245-4.
Larrieu, D., M. Brunet, C. Vargas, N. Hanoun, L. Ligat, L. Dagnon, H. Lulka, et al. “The E3 Ubiquitin Ligase TRIP12 Participates in Cell Cycle Progression and Chromosome Stability.” Scientific Reports 10, no. 1 (January 21, 2020): 789. https://doi.org/10.1038/s41598-020-57762-9.
Lumeau, Audrey, and Pierre Cordelier. “One Two Punch: Combination Chemotherapy Knocks Out Pancreatic Cancer.” Molecular Therapy 28, no. 8 (2020): 1751–52. https://doi.org/10.1016/j.ymthe.2020.07.014.
Nicolle, Rémy, Yuna Blum, Pauline Duconseil, Charles Vanbrugghe, Nicolas Brandone, Flora Poizat, Julie Roques, et al. “Establishment of a Pancreatic Adenocarcinoma Molecular Gradient (PAMG) That Predicts the Clinical Outcome of Pancreatic Cancer.” EBioMedicine 57 (2020): 102858. https://doi.org/10.1016/j.ebiom.2020.102858.
Frere, Corinne, Barbara Bournet, Sophie Gourgou, Julien Fraisse, Cindy Canivet, Jean M. Connors, Louis Buscail, et al. “Incidence of Venous Thromboembolism in Patients With Newly Diagnosed Pancreatic Cancer and Factors Associated With Outcomes.” Gastroenterology 158, no. 5 (2020): 1346-1358.e4. https://doi.org/10.1053/j.gastro.2019.12.009.
Amintas, Samuel, Véronique Vendrely, Charles Dupin, Louis Buscail, Christophe Laurent, Barbara Bournet, Jean-Philippe Merlio, et al. “Next-Generation Cancer Biomarkers: Extracellular Vesicle DNA as a Circulating Surrogate of Tumor DNA.” Frontiers in Cell and Developmental Biology 8 (2020): 622048. https://doi.org/10.3389/fcell.2020.622048.
PUBLICATIONS 2019
Diaz-Riascos, Zamira Vanessa, Mireia M. Ginesta, Joan Fabregat, Teresa Serrano, Juli Busquets, Louis Buscail, Pierre Cordelier, and Gabriel Capellá. “Expression and Role of MicroRNAs from the MiR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer.” Molecular Therapy. Nucleic Acids 17 (June 29, 2019): 491–503. https://doi.org/10.1016/j.omtn.2019.06.015.
Buscail, Etienne, Charlotte Maulat, Fabrice Muscari, Laurence Chiche, Pierre Cordelier, Sandrine Dabernat, Catherine Alix-Panabières, and Louis Buscail. “Liquid Biopsy Approach for Pancreatic Ductal Adenocarcinoma.” Cancers 11, no. 6 (June 19, 2019). https://doi.org/10.3390/cancers11060852.
Dromain, Clarisse, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin, Martyn E. Caplin, and CLARINET Study Group. “Tumor Growth Rate as a Metric of Progression, Response, and Prognosis in Pancreatic and Intestinal Neuroendocrine Tumors.” BMC Cancer 19, no. 1 (January 14, 2019): 66. https://doi.org/10.1186/s12885-018-5257-x.
Cacheux, Jean, Aurélien Bancaud, Thierry Leichlé, and Pierre Cordelier. “Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer.” Frontiers in Chemistry 7 (2019): 815. https://doi.org/10.3389/fchem.2019.00815.

team members

Nicolas Carrère
Enseignant-chercheur / Teacher-researcher
Charlotte Maulat
Etudiant ou stagiaire / PhD student or Trainee
Louis Buscail
Enseignant-chercheur / Teacher-researcher
Fabrice Muscari
Enseignant-chercheur / Teacher-researcher
Jérôme Torrisani
Chercheur / Researcher
Nikolaos Kontopoulos
Etudiant ou stagiaire / PhD student or Trainee
Pierre Cordelier
Chercheur / Researcher
Guillaume Labrousse
Ingénieur ou technicien / Engineer or Technician
Charlène Lopez
Ingénieur ou technicien / Engineer or Technician
Anaïs Cornebois
Etudiant ou stagiaire / PhD student or Trainee
Margaux Vienne
Chercheur / Researcher
Adèle Nevot
Ingénieur ou technicien / Engineer or Technician
Agathe Redouté
Etudiant ou stagiaire / PhD student or Trainee
Monireh Kazemimanesh
Chercheur / Researcher
Marie Sorbara
Etudiant ou stagiaire / PhD student or Trainee
Naïma Hanoun-Ziane
Ingénieur ou technicien / Engineer or Technician
Claire Vargas
Etudiant ou stagiaire / PhD student or Trainee
Nicolas Béry
Chercheur / Researcher

partnerships & Funding

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse – FR

Nous contacter

05 82 74 15 75

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