team
mARC POIROT & SANDRINE SILVENTE-POIROT
INOV :
Cholesterol Metabolism and
Therapeutic Innovations
Team labelled Ligue contre le Cancer
THE SPECIFICITIES
OF OUR RESEARCH AXIS
We explore the role of cholesterol metabolism in the control of tumor progression and in the resistance to therapies in several cancers (breast, skin, thyroid, leukemia). We are studying the biological properties and biosynthetic pathways of two metabolites that we have discovered: dendrogenin A (DDA) and oncosterone (OCDO) which are respectively tumor suppressor and tumor promoter metabolites. The ultimate goal of these studies is to develop new drug candidates and theranostic tools for new targeted and personalized cancer therapies. They will also define the role of the sterol component of the diet on the development of certain cancers.
oncometabolism
cholesterol
oxysterol
oncosterone
secretory vesicles
exosomes
dendrogenin
nuclear receptors
enzymes
metabolic imaging
research projects
Identification and characterization of new sterol metabolites
Dr Marc Poirot
Biochemical and pharmacological control of oncosterone production
Dr Philippe De Medina
Studies of the signaling pathways activated by oncosterone and dendrogenin a
Dr Sandrine Silvente-Poirot
New probes for non-invasive tumor detection by medical imaging
Dr. Philippe De Medina & Pr. Frédéric Courbon
Studies of deregulation of cholesterol metabolism in neuroendocrine cancers
Dr. Lavinia Vija
THE TEAM’S
FOCUS
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SCIENTIFIC PRODUCTIONS
PUBLICATIONS 2023
Pancaldi, Vera. “Network Models of Chromatin Structure.” Current Opinion in Genetics & Development 80 (June 2023): 102051. https://doi.org/10.1016/j.gde.2023.102051.
PUBLICATIONS 2022
Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “Celebrating the 10th Anniversary of the Creation of the European Network for Oxysterol Research (ENOR).” The Journal of Steroid Biochemistry and Molecular Biology 221 (July 2022): 106114. https://doi.org/10.1016/j.jsbmb.2022.106114.
Record, Michel, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, et al. “Targeting the Liver X Receptor with Dendrogenin A Differentiates Tumour Cells to Secrete Immunogenic Exosome-Enriched Vesicles.” Journal of Extracellular Vesicles 11, no. 4 (April 2022): e12211. https://doi.org/10.1002/jev2.12211.
Sabatier, Renaud, Cécile Vicier, Séverine Garnier, Arnaud Guille, Nadine Carbuccia, Nicolas Isambert, Florence Dalenc, et al. “Circulating Tumor DNA Predicts Efficacy of a Dual AKT/P70S6K Inhibitor (LY2780301) plus Paclitaxel in Metastatic Breast Cancer: Plasma Analysis of the TAKTIC Phase IB/II Study.” Molecular Oncology, February 5, 2022. https://doi.org/10.1002/1878-0261.13188.
Poirot, Marc. “Sterol Metabolism and Cancer.” Biochemical Pharmacology 196 (February 2022): 114843. https://doi.org/10.1016/j.bcp.2021.114843.
Khallouki, Farid, Somayya Saber, Toufik Bouddine, Lhoussain Hajji, Bachir Elbouhali, Sandrine Silvente-Poirot, and Marc Poirot. “In Vitro and In Vivo Oxidation and Cleavage Products of Tocols: From Chemical Tuners to ‘VitaminEome’ Therapeutics. A Narrative Review.” Food Bioscience 49 (2022): 101839. https://doi.org/10.1016/j.fbio.2022.101839.
Medina, Philippe de, Sandrine Silvente-Poirot, and Marc Poirot. “Oxysterols Are Potential Physiological Regulators of Ageing.” Ageing Research Reviews 77 (2022): 101615. https://doi.org/10.1016/j.arr.2022.101615.
PUBLICATIONS 2021
Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “European Network for Oxysterol Research (ENOR): 10 Th Anniversary.” The Journal of Steroid Biochemistry and Molecular Biology 214 (November 2021): 105996. https://doi.org/10.1016/j.jsbmb.2021.105996.
Websdale, Alex, Yi Kiew, Philip Chalmers, Xinyu Chen, Giorgia Cioccoloni, Thomas A. Hughes, Xinyu Luo, et al. “Pharmacologic and Genetic Inhibition of Cholesterol Esterification Enzymes Reduces Tumour Burden: A Systematic Review and Meta-Analysis of Preclinical Models.” Biochemical Pharmacology, August 15, 2021, 114731. https://doi.org/10.1016/j.bcp.2021.114731.
Medina, Philippe de, Khadijetou Diallo, Emilie Huc-Claustre, Mehdi Attia, Régis Soulès, Sandrine Silvente-Poirot, and Marc Poirot. “The 5,6-Epoxycholesterol Metabolic Pathway in Breast Cancer: Emergence of New Pharmacological Targets.” British Journal of Pharmacology 178, no. 16 (August 2021): 3248–60. https://doi.org/10.1111/bph.15205.
Montfort, Anne, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, et al. “Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.” Cancer Immunology Research 9, no. 5 (May 2021): 568–82. https://doi.org/10.1158/2326-6066.CIR-20-0342.
Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.
PUBLICATIONS 2020
Mouchel, Pierre-Luc, Nizar Serhan, Rémy Betous, Thomas Farge, Estelle Saland, Philippe De Medina, Jean-Sébastien Hoffmann, et al. “Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia.” Cancers 12, no. 10 (October 12, 2020): 2933. https://doi.org/10.3390/cancers12102933.
Serhan, Nizar, Pierre-Luc Mouchel, Philippe de Medina, Gregory Segala, Aurélie Mougel, Estelle Saland, Arnaud Rives, et al. “Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo.” Cancers 12, no. 7 (June 29, 2020): 1725. https://doi.org/10.3390/cancers12071725.
Alsuliman, Tamim, Caroline Baylet, Audrey Casabona, Marie-Pierre Dann, Natacha De Bentzmann, Marie-Laure Fontoura, Carole Genty, et al. “Vie sexuelle et affective après allogreffe de cellules souches hématopoïétiques : recommandations et livret patient de la SFGM-TC (Société francophone de greffe de moelle et de thérapie cellulaire).” Bulletin du Cancer, 2020, S0007455120302976. https://doi.org/10.1016/j.bulcan.2020.05.012.
Rodriguez-Estrada, M.T., V. Cardenia, M. Poirot, L. Iuliano, and G. Lizard. “Oxysterols and Sterols: From Lipidomics to Food Sciences.” The Journal of Steroid Biochemistry and Molecular Biology 196 (2020): 105515. https://doi.org/10.1016/j.jsbmb.2019.105515.
PUBLICATIONS 2019
Soulès, Régis, Fabien Audouard-Combe, Emilie Huc-Claustre, Philippe de Medina, Arnaud Rives, Etienne Chatelut, Florence Dalenc, et al. “A Fast UPLC-HILIC Method for an Accurate Quantification of Dendrogenin A in Human Tissues.” The Journal of Steroid Biochemistry and Molecular Biology 194 (August 12, 2019): 105447. https://doi.org/10.1016/j.jsbmb.2019.105447.
Poirot, Marc, Sandrine Silvente-Poirot, and Cholesterol metabolism and therapeutic innovations. “Oxysterols: An Expanding Family of Structurally Diversified Bioactive Steroids.” The Journal of Steroid Biochemistry and Molecular Biology, July 31, 2019, 105443. https://doi.org/10.1016/j.jsbmb.2019.105443.
Bauriaud-Mallet, Mathilde, Lavinia Vija-Racaru, Séverine Brillouet, Arnaud Mallinger, Philippe de Medina, Arnaud Rives, Bruno Payre, Marc Poirot, Fréderic Courbon, and Sandrine Silvente-Poirot. “The Cholesterol-Derived Metabolite Dendrogenin A Functionally Reprograms Breast Adenocarcinoma and Undifferentiated Thyroid Cancer Cells.” The Journal of Steroid Biochemistry and Molecular Biology 192 (June 3, 2019): 105390. https://doi.org/10.1016/j.jsbmb.2019.105390.
Fouache, Allan, Nada Zabaiou, Cyrille De Joussineau, Laurent Morel, Sandrine Silvente-Poirot, Amira Namsi, Gérard Lizard, et al. “Flavonoids Differentially Modulate Liver X Receptors Activity-Structure-Function Relationship Analysis.” The Journal of Steroid Biochemistry and Molecular Biology 190 (April 5, 2019): 173–82. https://doi.org/10.1016/j.jsbmb.2019.03.028.
Genovese, Salvatore, Francesco Epifano, Philippe de Medina, Nicolas Caron, Arnaud Rives, Marc Poirot, Sandrine Silvente-Poirot, and Serena Fiorito. “Natural and Semisynthetic Oxyprenylated Aromatic Compounds as Stimulators or Inhibitors of Melanogenesis.” Bioorganic Chemistry 87 (March 14, 2019): 181–90. https://doi.org/10.1016/j.bioorg.2019.03.026.
Taddeo, Vito Alessandro, Francesco Epifano, Francesca Preziuso, Serena Fiorito, Nicolas Caron, Arnaud Rives, Philippe de Medina, Marc Poirot, Sandrine Silvente-Poirot, and Salvatore Genovese. “HPLC Analysis and Skin Whitening Effects of Umbelliprenin-Containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris.” Molecules (Basel, Switzerland) 24, no. 3 (January 30, 2019). https://doi.org/10.3390/molecules24030501.
TEAM MEMBERS
PARTERNSHIPS & FUNDING
Toulouse Cancer Research Center (Oncopole)
Toulouse - FR
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+33 5 82 74 15 75
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