STÉPHANE PYRONNET & FABIENNE MEGGETTO
R’n Blood :
RNA Biology in Hematologic Tumors
The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer.
OF OUR RESEARCH AXIS
Post-transcriptional events involving RNAs allow for rapid control of gene expression at low energy cost to the cell. They are particularly solicited when cells are subjected to a stressed environment, as in a malignant tumor or under the effect of anti-tumor treatments. They can then contribute to the adaptation processes necessary for malignant transformation and/or resistance to treatments.
In a clinical perspective, using combined approaches of new generation and high throughput RNA sequencing (“bulk” or “single-cell RNAseq”) and cellular and tissue imaging, our team explores the whole RNA repertoire (coding mRNAs and non-coding regulatory RNAs including miRNAs, lncRNAs and circRNAs) and its heterogeneity within the tumor, in cohorts of patients with hematological tumors (acute myeloid leukemias and pediatric T lymphomas). The objective is the identification of new therapeutic and/or sensitizing targets.
On a cognitive and mechanistic level, the team then implements molecular (gain/loss of function), cellular and in vivo (genetic models and human tumor avatars or PDXs) experimental approaches for characterizing the new potential targets functionally and for deciphering their mechanisms of action. In partnership with industrialists, the possibility of targeting them with molecules offering a therapeutic potential is also explored.
Translation of mRNAs
Pediatric T lymphoma
Regulation of microarn and circular arn and their theranostic potential in alk tyrosine kinase-associated anaplastic t-cell lymphoma
Fabienne Meggetto & Laurence Lamant
partnerships & FUNDING
Centre de Recherches en Cancérologie de Toulouse (Oncopole)
Toulouse – FR
05 82 74 15 75
Envie de rejoindre
L’équipe du CRCT ?