Toulouse Cancer Laboratory of Excellence
The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in blood cancers and by extension in certain solid cancers.
A word from the director:
“We believe that these integrative approaches on massive data will provide an inexhaustible source of information on resistance phenomena in oncology that can potentially be exploited (biomarkers and therapeutic targets) while providing original training for our thesis students via an ambitious international doctoral programme.”
Prof. Pierre Brousset
Scientific Director of Labex Toucan
teams and platforms
AND F. MEGGETTO
R’n Blood :
RNA Biology In Hematologic Tumors
New Immunotherapies Against Lymphoma
et l. martinet
Genomic And Immunology Of Myeloma
Metabolism And Therapeutic Resistance In Acute Myeloid Leukemia
Molecular Dynamics Of Lymphocyte Interactions
Endothelial cells in Immunity, Inflammation and Cancer
Imag’IN is a technological platform offering its expertise for the study, implementation and analysis of projects involving histopathology, functional anatomy and biological imaging techniques.
In particular, we have recognised expertise in virtual microscopy and image analysis.
IUCT – CRCT
The bioinformatics platform of the Toulouse University Cancer Institute (IUCT) and the Toulouse Cancer Research Centre (CRCT) is made up of 12 bioinformaticians, statisticians and computer engineers with multidisciplinary expertise to handle the data generated by the various sequencing, cellular and tissue imaging platforms for research units (CRCT) and the hospital (IUCT) in routine practice. This work is based on a very high-speed computing cluster, GPUs and the development of innovative computing solutions.
To find biomarkers of resistance in haematopoietic cancers and potential therapeutic targets to circumvent this resistance.
Deciphering drug resistance in anaplastic large cell lymphomas expressing the oncogenic tyrosine kinase ALK.
Mapping γδT cells and vasculature in lymphoma: a single-cell study for the localization and functional characterization of cytolytic T cells infiltrating human lymphomas.
Immunometabolic landscape of myeloma associated with the efficacy of anti-CD38 mAbs.
Mitochondrial metabolism supports inhibitor resistance of IDH mutants in acute myeloid leukemia.
ALK-transformed mature T cells restore the characteristics of early thymus progenitors.
FAK activity in cancer-associated fibroblasts is a prognostic marker and a key metastatic drug player in pancreatic cancer
THE LABEX IN FIGURES
ENGINEERS & TECHNICIANS
RESEARCHERS & PERMANENT RESEARCH TEACHERS
LABEX & TRAINING
CARe Graduate School aims to train master and doctoral students in the field of cancer, ageing and rejuvenation.
The Phd Program within the CRCT complements this teaching by inviting students to participate in scientific animation.
PARTNERSHIPS & FUNDING
Centre de Recherches en Cancérologie de Toulouse (Oncopole)
Toulouse – FR
05 82 74 15 75
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L’équipe du CRCT ?