Équipe
mARC POIROT & SANDRINE SILVENTE-POIROT

 

INOV :

Métabolisme du cholestérol et
innovations thérapeutiques

Equipe labellisée Ligue contre le cancer

Les spécificités

de notre axe de recherche

Nous explorons le rôle du métabolisme du cholestérol dans le contrôle de la progression tumorale et dans la résistance aux thérapies dans plusieurs cancers (sein, peau, thyroïde, leucémies). Nous étudions les propriétés biologiques et les voies de biosynthèse de deux métabolites que nous avons découverts: la dendrogénine A (DDA) et l’oncostérone (OCDO) qui sont respectivement des métabolites suppresseur et promoteur de tumeurs. Ces études ont pour but ultime le développement de nouveaux candidats médicaments et d’outils théranostiques pour de nouvelles thérapies ciblées et personnalisée des cancers. Elles permettront en outre de définir le rôle de la composante stérol de l’alimentation sur le développement de certains cancers.

oncometabolism

cholesterol

oxysterol

oncosterone

vésicules de sécrétion

exosomes

dendrogenine

recepteurs nucléaires

enzymes

imagerie métabolique

DES PROJETS
DE RECHERCHE

LES FOCUS
DE L’ÉQUIPE

PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2023
Pancaldi, Vera. “Network Models of Chromatin Structure.” Current Opinion in Genetics & Development 80 (June 2023): 102051. https://doi.org/10.1016/j.gde.2023.102051.
PUBLICATIONS 2022
Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “Celebrating the 10th Anniversary of the Creation of the European Network for Oxysterol Research (ENOR).” The Journal of Steroid Biochemistry and Molecular Biology 221 (July 2022): 106114. https://doi.org/10.1016/j.jsbmb.2022.106114.
Record, Michel, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, et al. “Targeting the Liver X Receptor with Dendrogenin A Differentiates Tumour Cells to Secrete Immunogenic Exosome-Enriched Vesicles.” Journal of Extracellular Vesicles 11, no. 4 (April 2022): e12211. https://doi.org/10.1002/jev2.12211.
Sabatier, Renaud, Cécile Vicier, Séverine Garnier, Arnaud Guille, Nadine Carbuccia, Nicolas Isambert, Florence Dalenc, et al. “Circulating Tumor DNA Predicts Efficacy of a Dual AKT/P70S6K Inhibitor (LY2780301) plus Paclitaxel in Metastatic Breast Cancer: Plasma Analysis of the TAKTIC Phase IB/II Study.” Molecular Oncology, February 5, 2022. https://doi.org/10.1002/1878-0261.13188.
Poirot, Marc. “Sterol Metabolism and Cancer.” Biochemical Pharmacology 196 (February 2022): 114843. https://doi.org/10.1016/j.bcp.2021.114843.
Khallouki, Farid, Somayya Saber, Toufik Bouddine, Lhoussain Hajji, Bachir Elbouhali, Sandrine Silvente-Poirot, and Marc Poirot. “In Vitro and In Vivo Oxidation and Cleavage Products of Tocols: From Chemical Tuners to ‘VitaminEome’ Therapeutics. A Narrative Review.” Food Bioscience 49 (2022): 101839. https://doi.org/10.1016/j.fbio.2022.101839.
Medina, Philippe de, Sandrine Silvente-Poirot, and Marc Poirot. “Oxysterols Are Potential Physiological Regulators of Ageing.” Ageing Research Reviews 77 (2022): 101615. https://doi.org/10.1016/j.arr.2022.101615.
PUBLICATIONS 2021
Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “European Network for Oxysterol Research (ENOR): 10 Th Anniversary.” The Journal of Steroid Biochemistry and Molecular Biology 214 (November 2021): 105996. https://doi.org/10.1016/j.jsbmb.2021.105996.
Websdale, Alex, Yi Kiew, Philip Chalmers, Xinyu Chen, Giorgia Cioccoloni, Thomas A. Hughes, Xinyu Luo, et al. “Pharmacologic and Genetic Inhibition of Cholesterol Esterification Enzymes Reduces Tumour Burden: A Systematic Review and Meta-Analysis of Preclinical Models.” Biochemical Pharmacology, August 15, 2021, 114731. https://doi.org/10.1016/j.bcp.2021.114731.
Medina, Philippe de, Khadijetou Diallo, Emilie Huc-Claustre, Mehdi Attia, Régis Soulès, Sandrine Silvente-Poirot, and Marc Poirot. “The 5,6-Epoxycholesterol Metabolic Pathway in Breast Cancer: Emergence of New Pharmacological Targets.” British Journal of Pharmacology 178, no. 16 (August 2021): 3248–60. https://doi.org/10.1111/bph.15205.
Montfort, Anne, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, et al. “Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.” Cancer Immunology Research 9, no. 5 (May 2021): 568–82. https://doi.org/10.1158/2326-6066.CIR-20-0342.
Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.
PUBLICATIONS 2020
Mouchel, Pierre-Luc, Nizar Serhan, Rémy Betous, Thomas Farge, Estelle Saland, Philippe De Medina, Jean-Sébastien Hoffmann, et al. “Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia.” Cancers 12, no. 10 (October 12, 2020): 2933. https://doi.org/10.3390/cancers12102933.
Serhan, Nizar, Pierre-Luc Mouchel, Philippe de Medina, Gregory Segala, Aurélie Mougel, Estelle Saland, Arnaud Rives, et al. “Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo.” Cancers 12, no. 7 (June 29, 2020): 1725. https://doi.org/10.3390/cancers12071725.
Alsuliman, Tamim, Caroline Baylet, Audrey Casabona, Marie-Pierre Dann, Natacha De Bentzmann, Marie-Laure Fontoura, Carole Genty, et al. “Vie sexuelle et affective après allogreffe de cellules souches hématopoïétiques : recommandations et livret patient de la SFGM-TC (Société francophone de greffe de moelle et de thérapie cellulaire).” Bulletin du Cancer, 2020, S0007455120302976. https://doi.org/10.1016/j.bulcan.2020.05.012.
Rodriguez-Estrada, M.T., V. Cardenia, M. Poirot, L. Iuliano, and G. Lizard. “Oxysterols and Sterols: From Lipidomics to Food Sciences.” The Journal of Steroid Biochemistry and Molecular Biology 196 (2020): 105515. https://doi.org/10.1016/j.jsbmb.2019.105515.
PUBLICATIONS 2019
Soulès, Régis, Fabien Audouard-Combe, Emilie Huc-Claustre, Philippe de Medina, Arnaud Rives, Etienne Chatelut, Florence Dalenc, et al. “A Fast UPLC-HILIC Method for an Accurate Quantification of Dendrogenin A in Human Tissues.” The Journal of Steroid Biochemistry and Molecular Biology 194 (August 12, 2019): 105447. https://doi.org/10.1016/j.jsbmb.2019.105447.
Poirot, Marc, Sandrine Silvente-Poirot, and Cholesterol metabolism and therapeutic innovations. “Oxysterols: An Expanding Family of Structurally Diversified Bioactive Steroids.” The Journal of Steroid Biochemistry and Molecular Biology, July 31, 2019, 105443. https://doi.org/10.1016/j.jsbmb.2019.105443.
Bauriaud-Mallet, Mathilde, Lavinia Vija-Racaru, Séverine Brillouet, Arnaud Mallinger, Philippe de Medina, Arnaud Rives, Bruno Payre, Marc Poirot, Fréderic Courbon, and Sandrine Silvente-Poirot. “The Cholesterol-Derived Metabolite Dendrogenin A Functionally Reprograms Breast Adenocarcinoma and Undifferentiated Thyroid Cancer Cells.” The Journal of Steroid Biochemistry and Molecular Biology 192 (June 3, 2019): 105390. https://doi.org/10.1016/j.jsbmb.2019.105390.
Fouache, Allan, Nada Zabaiou, Cyrille De Joussineau, Laurent Morel, Sandrine Silvente-Poirot, Amira Namsi, Gérard Lizard, et al. “Flavonoids Differentially Modulate Liver X Receptors Activity-Structure-Function Relationship Analysis.” The Journal of Steroid Biochemistry and Molecular Biology 190 (April 5, 2019): 173–82. https://doi.org/10.1016/j.jsbmb.2019.03.028.
Genovese, Salvatore, Francesco Epifano, Philippe de Medina, Nicolas Caron, Arnaud Rives, Marc Poirot, Sandrine Silvente-Poirot, and Serena Fiorito. “Natural and Semisynthetic Oxyprenylated Aromatic Compounds as Stimulators or Inhibitors of Melanogenesis.” Bioorganic Chemistry 87 (March 14, 2019): 181–90. https://doi.org/10.1016/j.bioorg.2019.03.026.
Taddeo, Vito Alessandro, Francesco Epifano, Francesca Preziuso, Serena Fiorito, Nicolas Caron, Arnaud Rives, Philippe de Medina, Marc Poirot, Sandrine Silvente-Poirot, and Salvatore Genovese. “HPLC Analysis and Skin Whitening Effects of Umbelliprenin-Containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris.” Molecules (Basel, Switzerland) 24, no. 3 (January 30, 2019). https://doi.org/10.3390/molecules24030501.

LES MEMBRES DE L’ÉQUIPE

Lavinia Vija
Clinicien Chercheur / Researcher hospital practitioner
Michel Record
Chercheur statutaire / permanent scientist
Marc Poirot
Chercheur statutaire / permanent scientist
Sandrine Poirot
Chercheur statutaire / permanent scientist
Julio Bunay
Chercheur Post-Doctorant / Post-Doc researcher
Séverine Brillouet
Clinicien Chercheur / Researcher hospital practitioner
Philippe De-Medina
Ingénieur de laboratoire / laboratory engineer
Khadijetou Diallo
Doctorant / PhD student
Laly Pucheu
Technicien de laboratoire / Laboratory Technician
Ayadi Silia
Doctorant / PhD student

LES PARTENAIRES & FINANCIERS

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

2, avenue Hubert Curien
31037 - Toulouse - FR

Nous contacter

05 82 74 15 75

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