Équipe
Frédéric Chibon

ONCOSARC :

Oncogenèse des sarcomes

Les spécificités
de notre axe de recherches

Sarcome

Différenciation

Diagnostic

Génome

Oncogenèse

Pronostic

Chromosome

Metastase

Cellule tumorale hybride

Mitose

Traitement

Hétérogénéité

DES PROJETS
DE RECHERCHE

Aucun résultat

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Le groupe "Oncogenèse des sarcomes" de l'ONCOPOLE de Toulouse cherche à se renforcer, pour développer de nouveaux axes. Recherchons CR/DR INSERM.
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PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2021
Brito, Ariadna, Candice Merle, Pauline Lagarde, Benjamin Faustin, Anne Devin, Lydia Lartigue, and Frederic Chibon. “Cell Fusion Enhances Energy Metabolism of Mesenchymal Tumor Hybrid Cells to Sustain Their Proliferation and Invasion.” BMC Cancer 21, no. 1 (July 28, 2021): 863. https://doi.org/10.1186/s12885-021-08561-6.
Beddok, Arnaud, Gaëlle Pérot, Sophie Le Guellec, Noémie Thebault, Alexandre Coutte, Henri Sevestre, Bruno Chauffert, and Frédéric Chibon. “Germinal GLT8D1, GATAD2A and SLC25A39 Mutations in a Patient with a Glomangiopericytal Tumor and Five Different Sarcomas over a 10-Year Period.” Scientific Reports 11, no. 1 (May 7, 2021): 9765. https://doi.org/10.1038/s41598-021-88671-0.
Darmusey, Lucie, Gaëlle Pérot, Noémie Thébault, Sophie Le Guellec, Nelly Desplat, Laëtitia Gaston, Lucile Delespaul, et al. “ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas.” Cancers 13, no. 9 (April 29, 2021). https://doi.org/10.3390/cancers13092151.
Merle, Candice, Pauline Lagarde, Lydia Lartigue, and Frédéric Chibon. “Acquisition of Cancer Stem Cell Capacities after Spontaneous Cell Fusion.” BMC Cancer 21, no. 1 (March 7, 2021): 241. https://doi.org/10.1186/s12885-021-07979-2.
Brahmi, M., T. Lesluyes, A. Dufresne, M. Toulmonde, A. Italiano, O. Mir, A. Le Cesne, et al. “Expression and Prognostic Significance of PDGF Ligands and Receptors across Soft Tissue Sarcomas.” ESMO Open 6, no. 1 (February 2021): 100037. https://doi.org/10.1016/j.esmoop.2020.100037.
PUBLICATIONS 2020
Croce, Sabrina, and Frédéric Chibon. “Molecular Prognostication of Uterine Smooth Muscle Neoplasms: From CGH Array to CINSARC Signature and Beyond.” Genes, Chromosomes and Cancer, November 11, 2020, gcc.22906. https://doi.org/10.1002/gcc.22906.
Lesluyes, Tom, and Frédéric Chibon. “A Global and Integrated Analysis of CINSARC-Associated Genetic Defects.” Cancer Research, October 6, 2020, canres.0512.2020. https://doi.org/10.1158/0008-5472.CAN-20-0512.
Cissé, Madi Y., Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, et al. “Targeting MDM2-Dependent Serine Metabolism as a Therapeutic Strategy for Liposarcoma.” Science Translational Medicine 12, no. 547 (June 10, 2020): eaay2163. https://doi.org/10.1126/scitranslmed.aay2163.
Merle, Candice, Noémie Thébault, Sophie LeGuellec, Jessica Baud, Gaëlle Pérot, Tom Lesluyes, Lucile Delespaul, Lydia Lartigue, and Frédéric Chibon. “Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion.” Cancers 12, no. 5 (May 19, 2020): 1281. https://doi.org/10.3390/cancers12051281.
Lartigue, Lydia, Candice Merle, Pauline Lagarde, Lucile Delespaul, Tom Lesluyes, Sophie Le Guellec, Gaelle Pérot, Laura Leroy, Jean-Michel Coindre, and Frédéric Chibon. “Genome Remodeling upon Mesenchymal Tumor Cell Fusion Contributes to Tumor Progression and Metastatic Spread.” Oncogene 39, no. 21 (May 2020): 4198–4211. https://doi.org/10.1038/s41388-020-1276-6.
Mattei, Jean Camille, Corinne Bouvier-Labit, Doriane Barets, Nicolas Macagno, Mathieu Chocry, Frédéric Chibon, Philippe Morando, et al. “Pan Aurora Kinase Inhibitor: A Promising Targeted-Therapy in Dedifferentiated Liposarcomas With Differential Efficiency Depending on Sarcoma Molecular Profile.” Cancers 12, no. 3 (March 3, 2020). https://doi.org/10.3390/cancers12030583.
Jakob, Jens, Tom Lesluyes, Anna Simeonova-Chergou, Frederik Wenz, Peter Hohenberger, Frederic Chibon, and Sophie Le Guellec. “Impact of Preoperative Treatment on the CINSARC Prognostic Signature: Translational Research Results from a Phase 1 Trial of the German Interdisciplinary Sarcoma Group (GISG 03).” Strahlentherapie Und Onkologie: Organ Der Deutschen Rontgengesellschaft ... [et Al] 196, no. 3 (March 2020): 280–85. https://doi.org/10.1007/s00066-019-01543-5.
Salas, Sébastien, and Frédéric Chibon. “Biology and signaling pathways involved in the oncogenesis of desmoid tumors.” Bulletin Du Cancer, January 16, 2020. https://doi.org/10.1016/j.bulcan.2019.12.003.
Dufresne, A., T. Lesluyes, C. Ménétrier-Caux, M. Brahmi, E. Darbo, M. Toulmonde, A. Italiano, et al. “Specific Immune Landscapes and Immune Checkpoint Expressions in Histotypes and Molecular Subtypes of Sarcoma.” OncoImmunology 9, no. 1 (January 1, 2020): 1792036. https://doi.org/10.1080/2162402X.2020.1792036.
Delespaul, Lucile, Caroline Gélabert, Tom Lesluyes, Sophie Le Guellec, Gaëlle Pérot, Laura Leroy, Jessica Baud, Candice Merle, Lydia Lartigue, and Frédéric Chibon. “Cell–Cell Fusion of Mesenchymal Cells with Distinct Differentiations Triggers Genomic and Transcriptomic Remodelling toward Tumour Aggressiveness.” Scientific Reports 10, no. 1 (2020): 21634. https://doi.org/10.1038/s41598-020-78502-z.
Filleron, Thomas, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, et al. “Value of Peri-Operative Chemotherapy in Patients with CINSARC High-Risk Localized Grade 1 or 2 Soft Tissue Sarcoma: Study Protocol of the Target Selection Phase III CHIC-STS Trial.” BMC Cancer 20, no. 1 (2020): 716. https://doi.org/10.1186/s12885-020-07207-3.
Guérin, Amandine, Delphine Martire, Eva Trenquier, Tom Lesluyes, Sébastien Sagnol, Marine Pratlong, Elise Lefebvre, Fréderic Chibon, Pascal Santa Barbara, and Sandrine Faure. “LIX1 Regulates YAP Activity and Controls Gastrointestinal Cancer Cell Plasticity.” Journal of Cellular and Molecular Medicine 24, no. 16 (2020): 9244–54. https://doi.org/10.1111/jcmm.15569.
Croce, Sabrina, Tom Lesluyes, Carine Valle, Loubna M’Hamdi, Noémie Thébault, Gaëlle Pérot, Eberhard Stoeckle, et al. “The Nanocind Signature Is an Independent Prognosticator of Recurrence and Death in Uterine Leiomyosarcomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 26, no. 4 (15 2020): 855–61. https://doi.org/10.1158/1078-0432.CCR-19-2891.
PUBLICATIONS 2019
Delespaul, Lucile, Candice Merle, Tom Lesluyes, Pauline Lagarde, Sophie Le Guellec, Gaëlle Pérot, Jessica Baud, et al. “Fusion-Mediated Chromosomal Instability Promotes Aneuploidy Patterns That Resemble Human Tumors.” Oncogene, July 3, 2019. https://doi.org/10.1038/s41388-019-0859-6.
Mauduit, Olivier, Vanessa Delcroix, Tom Lesluyes, Gaëlle Pérot, Pauline Lagarde, Lydia Lartigue, Jean-Yves Blay, and Frédéric Chibon. “Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas.” Cancers 11, no. 7 (July 1, 2019). https://doi.org/10.3390/cancers11070922.
Lesluyes, Tom, Jessica Baud, Gaëlle Pérot, Céline Charon-Barra, Axel You, Isabelle Valo, Céline Bazille, et al. “Genomic and Transcriptomic Comparison of Post-Radiation versus Sporadic Sarcomas.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, June 26, 2019. https://doi.org/10.1038/s41379-019-0300-2.
Chibon, Frédéric, Elodie Darbo, and Gaëlle Pérot. “Leiomyosarcomas: Whole Genome Sequencing for a Whole Biology Characterization.” Current Opinion in Oncology, April 24, 2019. https://doi.org/10.1097/CCO.0000000000000550.
Le Loarer, François, Sophie Laffont, Tom Lesluyes, Franck Tirode, Cristina Antonescu, Anne-Catherine Baglin, Lucile Delespaul, et al. “Clinicopathologic and Molecular Features of a Series of 41 Biphenotypic Sinonasal Sarcomas Expanding Their Molecular Spectrum.” The American Journal of Surgical Pathology, March 1, 2019. https://doi.org/10.1097/PAS.0000000000001238.
Vitiello, Gerardo A., Timothy G. Bowler, Mengyuan Liu, Benjamin D. Medina, Jennifer Q. Zhang, Nesteene J. Param, Jennifer K. Loo, et al. “Differential Immune Profiles Distinguish the Mutational Subtypes of Gastrointestinal Stromal Tumor.” The Journal of Clinical Investigation, February 14, 2019. https://doi.org/10.1172/JCI124108.
Mauduit, Olivier, Céline Brulard, Tom Lesluyes, Vanessa Delcroix, Gaëlle Pérot, Nina Choublier, Mickael Michaud, et al. “RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas.” Cancers 11, no. 1 (January 11, 2019). https://doi.org/10.3390/cancers11010081.
Valentin, T., T. Lesluyes, S. Le Guellec, and F. Chibon. “Chemotherapy in Localized Soft Tissue Sarcoma: Will We Soon Have to Treat Grade 1 Tumors? Update on CINSARC Performances.” Annals of Oncology: Official Journal of the European Society for Medical Oncology 30, no. 1 (January 1, 2019): 153–55. https://doi.org/10.1093/annonc/mdy465.
Timbergen, Milea J. M., Matthijs L. Janssen, Cornelis Verhoef, Dirk J. Grünhagen, Frederic Chibon, Marcel Smid, Stefan Sleijfer, and Erik A. C. Wiemer. “Wnt Targets Genes Are Not Differentially Expressed in Desmoid Tumors Bearing Different Activating β-Catenin Mutations.” European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 45, no. 4 (2019): 691–98. https://doi.org/10.1016/j.ejso.2018.09.019.
Croce, Sabrina, Tom Lesluyes, Lucile Delespaul, Benjamin Bonhomme, Gaëlle Pérot, Valérie Velasco, Laetitia Mayeur, et al. “GREB1-CTNNB1 Fusion Transcript Detected by RNA-Sequencing in a Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Novel CTNNB1 Rearrangement.” Genes, Chromosomes & Cancer 58, no. 3 (2019): 155–63. https://doi.org/10.1002/gcc.22694.
Chibon, Frederic, Tom Lesluyes, Thibaud Valentin, and Sophie Le Guellec. “CINSARC Signature as a Prognostic Marker for Clinical Outcome in Sarcomas and Beyond.” Genes, Chromosomes & Cancer 58, no. 2 (2019): 124–29. https://doi.org/10.1002/gcc.22703.

LES MEMBRES DE L’ÉQUIPE

Valentin Thibaud
Personnel hospitalier / Hospital Staff
Frédéric Chibon
Chercheur / Researcher
Gaëlle Pérot
Ingénieur ou technicien / Engineer and Technician
Joanna Fourquet
Ingénieur ou technicien / Engineer and Technician
Sofia Galanou
Etudiant ou stagiaire / PhD student and Trainee
Ariadna Brito
Etudiant ou stagiaire / PhD student and Trainee
Anne Gomez-Brouchet
Enseignant-chercheur / Teacher-researcher

LES PARTENAIRES & FINANCIERS

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse - FR

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05 82 74 15 75

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