Équipe
Elizabeth Cohen-Jonathan Moyal

RADOPT :

Optimisation de la radiothérapie: des voies de signalisation moléculaires aux essais cliniques

LES FOCUS
DE L’ÉQUIPE

PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2022
Duval, Tanguy, Jean-Albert Lotterie, Anthony Lemarie, Caroline Delmas, Fatima Tensaouti, Elizabeth Cohen-Jonathan Moyal, and Vincent Lubrano. “Glioblastoma Stem-like Cell Detection Using Perfusion and Diffusion MRI.” Cancers 14, no. 11 (June 4, 2022): 2803. https://doi.org/10.3390/cancers14112803.
Tensaouti, Fatima, Franck Desmoulin, Julia Gilhodes, Elodie Martin, Soleakhena Ken, Jean-Albert Lotterie, Georges Noël, et al. “Quality Control of 3D MRSI Data in Glioblastoma: Can We Do without the Experts?” Magnetic Resonance in Medicine 87, no. 4 (April 2022): 1688–99. https://doi.org/10.1002/mrm.29098.
Acquitter, Clément, Lucie Piram, Umberto Sabatini, Julia Gilhodes, Elizabeth Moyal Cohen-Jonathan, Soleakhena Ken, and Benjamin Lemasson. “Radiomics-Based Detection of Radionecrosis Using Harmonized Multiparametric MRI.” Cancers 14, no. 2 (January 7, 2022): 286. https://doi.org/10.3390/cancers14020286.
Balosso, J., F. Missohou, D. Antoni, C. Hennequin, M.-A. Mahé, L. Simon, and C. Demoor-Goldschmidt. “Radiotherapy of Lymphomas.” Cancer/Radiothérapie 26, no. 1–2 (2022): 388–96. https://doi.org/10.1016/j.canrad.2021.11.007.
Darréon, J., G. Bouilhol, N. Aillières, H. Bouscayrol, L. Simon, and M. Ayadi. “Respiratory Motion Management for External Radiotherapy Treatment.” Cancer/Radiothérapie 26, no. 1–2 (2022): 50–58. https://doi.org/10.1016/j.canrad.2021.09.006.
Grégoire, V., P. Giraud, L. Vieillevigne, and P. Maingon. “Management of Oropharyngeal Squamous Cell Carcinoma.” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique 26, no. 1–2 (April 2022): 174–88. https://doi.org/10.1016/j.canrad.2021.10.002.
Grégoire, V., S. Boisbouvier, P. Giraud, P. Maingon, Y. Pointreau, and L. Vieillevigne. “Management and Work-up Procedures of Patients with Head and Neck Malignancies Treated by Radiation.” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique 26, no. 1–2 (April 2022): 147–55. https://doi.org/10.1016/j.canrad.2021.10.005.
Delbaere, Alexia, Tony Younes, Luc Simon, Catherine Khamphan, and Laure Vieillevigne. “Field Output Correction Factors and Electron Fluence Perturbation of the MicroSilicon and MicroSilicon X Detectors.” Physics in Medicine and Biology 67, no. 8 (April 7, 2022). https://doi.org/10.1088/1361-6560/ac5e5e.
Deshors, Pauline, Florent Arnauduc, Betty Boëlle, Elizabeth Cohen-Jonathan Moyal, Monique Courtade-Saïdi, and Solène M. Evrard. “Impact of Regorafenib on Endothelial Transdifferentiation of Glioblastoma Stem-like Cells.” Cancers 14, no. 6 (March 18, 2022): 1551. https://doi.org/10.3390/cancers14061551.
Garnier, Louis, Chrystelle Vidal, Olivier Chinot, Elisabeth Cohen-Jonathan Moyal, Apolline Djelad, Charlotte Bronnimann, Lien Bekaert, et al. “Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study.” The Oncologist 27, no. 5 (May 6, 2022): 414–23. https://doi.org/10.1093/oncolo/oyac023.
Tauziède-Espariat, Arnault, Aurore Siegfried, Yvan Nicaise, Dominique Figarella-Branger, Romain Appay, Suhan Senova, Dorian Bochaton, et al. “A Novel YAP1-MAML2 Fusion in an Adult Supra-Tentorial Ependymoma, YAP1-Fused.” Brain Tumor Pathology, May 22, 2022. https://doi.org/10.1007/s10014-022-00439-0.
Monteiro, Cátia, Lauritz Miarka, María Perea-García, Neibla Priego, Pedro García-Gómez, Laura Álvaro-Espinosa, Ana de Pablos-Aragoneses, et al. “Stratification of Radiosensitive Brain Metastases Based on an Actionable S100A9/RAGE Resistance Mechanism.” Nature Medicine, April 11, 2022. https://doi.org/10.1038/s41591-022-01749-8.
Tauziède-Espariat, Arnault, Philipp Sievers, Frédérique Larousserie, Joseph Benzakoun, Delphine Guillemot, Gaëlle Pierron, Mathilde Duchesne, et al. “An Integrative Histopathological and Epigenetic Characterization of Primary Intracranial Mesenchymal Tumors, FET:CREB-Fused Broadening the Spectrum of Tumor Entities in Comparison with Their Soft Tissue Counterparts.” Brain Pathology (Zurich, Switzerland) 32, no. 1 (January 2022): e13010. https://doi.org/10.1111/bpa.13010.
Métais, Alice, Romain Appay, Mélanie Pagès, Catherine Gallardo, Karen Silva, Aurore Siegfried, Romain Perbet, et al. “Low-Grade Epilepsy-Associated Neuroepithelial Tumours with a Prominent Oligodendroglioma-like Component: The Diagnostic Challenges.” Neuropathology and Applied Neurobiology 48, no. 2 (February 2022): e12769. https://doi.org/10.1111/nan.12769.
Appay, Romain, Franck Bielle, Philipp Sievers, Doriane Barets, Frédéric Fina, Jean Boutonnat, Adam Clovis, et al. “Rosette-Forming Glioneuronal Tumours Are Midline, FGFR1-Mutated Tumours.” Neuropathology and Applied Neurobiology, March 16, 2022, e12813. https://doi.org/10.1111/nan.12813.
Sidibe, Ingrid, Fatima Tensaouti, Margaux Roques, Elizabeth Cohen-Jonathan-Moyal, and Anne Laprie. “Pseudoprogression in Glioblastoma: Role of Metabolic and Functional MRI-Systematic Review.” Biomedicines 10, no. 2 (January 26, 2022): 285. https://doi.org/10.3390/biomedicines10020285.
Maingon, P., V. Marchesi, D. Azria, J. Balosso, É Deutsch, É Cohen Jonathan-Moyal, P. Giraud, and É Bayart. “RadioTransNet: Preclinical Research Network Coordinated at the SFRO and SFPM.” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique 26, no. 1–2 (April 2022): 108–15. https://doi.org/10.1016/j.canrad.2021.08.003.
Hennequin, C., D. Azria, P. Blanchard, G. Créhange, É Deutsch, A. Lisbona, É Moyal, et al. “Specificities of Clinical Research in Radiotherapy.” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique 26, no. 1–2 (April 2022): 104–7. https://doi.org/10.1016/j.canrad.2021.11.011.
PUBLICATIONS 2021
Robert, C., A. Munoz, D. Moreau, J. Mazurier, G. Sidorski, A. Gasnier, G. Beldjoudi, et al. “Clinical Implementation of Deep-Learning Based Auto-Contouring Tools–Experience of Three French Radiotherapy Centers.” Cancer/Radiothérapie 25, no. 6–7 (2021): 607–16. https://doi.org/10.1016/j.canrad.2021.06.023.
Meyer, P., M.-C. Biston, C. Khamphan, T. Marghani, J. Mazurier, V. Bodez, L. Fezzani, et al. “Automation in Radiotherapy Treatment Planning: Examples of Use in Clinical Practice and Future Trends for a Complete Automated Workflow.” Cancer/Radiothérapie 25, no. 6–7 (2021): 617–22. https://doi.org/10.1016/j.canrad.2021.06.006.
Simon, L., C. Robert, and P. Meyer. “Artificial Intelligence for Quality Assurance in Radiotherapy.” Cancer/Radiothérapie 25, no. 6–7 (2021): 623–26. https://doi.org/10.1016/j.canrad.2021.06.012.
Leste, Jeremy, Tony Younes, Maxime Chauvin, Xavier Franceries, Alexia Delbaere, Laure Vieillevigne, Regis Ferrand, Manuel Bardies, and Luc Simon. “Technical Note: GAMMORA, a Free, Open-Source, and Validated GATE-Based Model for Monte-Carlo Simulations of the Varian TrueBeam.” Physica Medica 89 (2021): 211–18. https://doi.org/10.1016/j.ejmp.2021.07.037.
Attal, J., B. Cabarrou, T. Valentin, J. P. Nesseler, E. Stoeckle, A. Ducassou, T. Filleron, et al. “Evaluation of Two Modalities of Perioperative Treatment in the Management of Extremity and Truncal Soft Tissue Sarcomas: Neoadjuvant Concurrent Chemoradiotherapy and Sequential Treatment.” Strahlentherapie Und Onkologie: Organ Der Deutschen Rontgengesellschaft ... [et Al] 197, no. 12 (December 2021): 1051–62. https://doi.org/10.1007/s00066-021-01847-5.
Alhalabi, Karam T., Damian Stichel, Philipp Sievers, Heike Peterziel, Alexander C. Sommerkamp, Dominik Sturm, Andrea Wittmann, et al. “PATZ1 Fusions Define a Novel Molecularly Distinct Neuroepithelial Tumor Entity with a Broad Histological Spectrum.” Acta Neuropathologica 142, no. 5 (November 2021): 841–57. https://doi.org/10.1007/s00401-021-02354-8.
Sacko, Oumar, Alexandra Benouaich-Amiel, Pierre Brandicourt, Mahamadou Niaré, Saloua Charni, Clarissa Cavandoli, David Brauge, et al. “The Impact of Surgery on the Survival of Patients with Recurrent Glioblastoma.” Asian Journal of Neurosurgery 16, no. 1 (2021): 1–7. https://doi.org/10.4103/ajns.AJNS_180_20.
Dalmasso, Céline, Cécile Pagès, Léonor Chaltiel, Vincent Sibaud, Elisabeth Moyal, Ciprian Chira, Jean Christophe Sol, Igor Latorzeff, Nicolas Meyer, and Anouchka Modesto. “Intracranial Treatment in Melanoma Patients with Brain Metastasis Is Associated with Improved Survival in the Era of Immunotherapy and Anti-BRAF Therapy.” Cancers 13, no. 17 (2021): 4493. https://doi.org/10.3390/cancers13174493.
Roth, P., A. Pace, E. Le Rhun, M. Weller, C. Ay, E. Cohen-Jonathan Moyal, M. Coomans, et al. “Neurological and Vascular Complications of Primary and Secondary Brain Tumours: EANO-ESMO Clinical Practice Guidelines for Prophylaxis, Diagnosis, Treatment and Follow-Up.” Annals of Oncology: Official Journal of the European Society for Medical Oncology 32, no. 2 (2021): 171–82. https://doi.org/10.1016/j.annonc.2020.11.003.
Esteyrie, Vincent, Caroline Dehais, Elodie Martin, Catherine Carpentier, Emmanuelle Uro-Coste, Dominique Figarella-Branger, Charlotte Bronniman, et al. “Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort.” The Oncologist 26, no. 5 (2021): e838–46. https://doi.org/10.1002/onco.13701.
Peyraga, G., A. Ducassou, F.-X. Arnaud, T. Lizée, J. Pouédras, and É Moyal. “[Radiotherapy and spinal toxicity: News and perspectives].” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique 25, no. 1 (2021): 55–61. https://doi.org/10.1016/j.canrad.2020.05.017.
Picart, Thiébaud, Marc Barritault, Delphine Poncet, Lise-Prune Berner, Cristina Izquierdo, Emeline Tabouret, Dominique Figarella-Branger, et al. “Characteristics of Diffuse Hemispheric Gliomas, H3 G34-Mutant in Adults,” 2021.
Pinto, Giulia, Inés Saenz-de-Santa-Maria, Patricia Chastagner, Emeline Perthame, Caroline Delmas, Christine Toulas, Elizabeth Moyal-Jonathan-Cohen, Christel Brou, and Chiara Zurzolo. “Patient-Derived Glioblastoma Stem Cells Transfer Mitochondria through Tunneling Nanotubes in Tumor Organoids.” The Biochemical Journal 478, no. 1 (2021): 21–39. https://doi.org/10.1042/BCJ20200710.
Tauziède-Espariat, Arnault, Aurore Siegfried, Yvan Nicaise, Thomas Kergrohen, Philipp Sievers, Alexandre Vasiljevic, Alexandre Roux, et al. “Supratentorial Non-RELA, ZFTA-Fused Ependymomas: A Comprehensive Phenotype Genotype Correlation Highlighting the Number of Zinc Fingers in ZFTA-NCOA1/2 Fusions.” Acta Neuropathologica Communications 9, no. 1 (August 13, 2021): 135. https://doi.org/10.1186/s40478-021-01238-y.
Leste, Jeremy, Imene Medjahed, Maxime Chauvin, Tony Younes, Laure Vieillevigne, Regis Ferrand, Xavier Franceries, Manuel Bardies, and Luc Simon. “A Study of the Interplay Effect in Radiation Therapy Using a Monte-Carlo Model.” Physica Medica: PM: An International Journal Devoted to the Applications of Physics to Medicine and Biology: Official Journal of the Italian Association of Biomedical Physics (AIFB) 87 (July 2021): 73–82. https://doi.org/10.1016/j.ejmp.2021.05.019.
Younes, Tony, Maxime Chauvin, Alexia Delbaere, Joey Labour, Victoria Fonteny, Luc Simon, Georges Fares, and Laure Vieillevigne. “Towards the Standardization of the Absorbed Dose Report Mode in High Energy Photon Beams.” Physics in Medicine and Biology 66, no. 4 (February 2, 2021): 045009. https://doi.org/10.1088/1361-6560/abd22c.
Khalifa, Jonathan, Julien Mazieres, Carlos Gomez-Roca, Maha Ayyoub, and Elizabeth Cohen-Jonathan Moyal. “Radiotherapy in the Era of Immunotherapy With a Focus on Non-Small-Cell Lung Cancer: Time to Revisit Ancient Dogmas?” Frontiers in Oncology 11 (2021): 662236. https://doi.org/10.3389/fonc.2021.662236.
PUBLICATIONS 2020
Kowalski-Chauvel, Aline, Marie Géraldine Lacore, Florent Arnauduc, Caroline Delmas, Christine Toulas, Elizabeth Cohen-Jonathan-Moyal, and Catherine Seva. “The M6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells.” Cancers 13, no. 1 (December 25, 2020): 40. https://doi.org/10.3390/cancers13010040.
Bertorello, Juliette, Julie Sesen, Julia Gilhodes, Solène Evrard, Monique Courtade-Saïdi, Meera Augustus, Emmanuelle Uro-Coste, et al. “Translation Reprogramming by EIF3 Linked to Glioblastoma Resistance.” NAR Cancer 2, no. 3 (September 2020): zcaa020. https://doi.org/10.1093/narcan/zcaa020.
Leste, Jermey, Imene Medjahed, François-Xavier Arnaud, Regis Ferrand, Xavier Franceries, Manuel Bardies, and Luc Simon. “A Study of the Interplay Effect for VMAT SBRT Using a Four-Axes Motion Phantom.” Journal of Applied Clinical Medical Physics, June 23, 2020. https://doi.org/10.1002/acm2.12947.
Gouazé-Andersson, Valérie, and Elizabeth Cohen-Jonathan Moyal. “New Avenues in Radiotherapy of Glioblastoma: From Bench to Bedside.” Current Treatment Options in Neurology 22, no. 12 (2020): 45. https://doi.org/10.1007/s11940-020-00654-0.
Dalmasso, Céline, Cécile Pagès, Léonor Chaltiel, Aurore Brun, Vincent Sibaud, Serge Boulinguez, Ciprian Chira, et al. “Survival Estimation of Melanoma Patients with Brain Metastasis Using the Melanoma-MolGPA Score: External Validation from a French Cohort.” Melanoma Research 30, no. 5 (2020): 472–76. https://doi.org/10.1097/CMR.0000000000000670.
De Barros, Amaury, Justine Attal, Margaux Roques, Julien Nicolau, Jean-Christophe Sol, Saloua Charni, Elizabeth Cohen-Jonathan-Moyal, and Franck-Emmanuel Roux. “Glioblastoma Survival Is Better Analyzed on Preradiotherapy MRI than on Postoperative MRI Residual Volumes: A Retrospective Observational Study.” Clinical Neurology and Neurosurgery 196 (2020): 105972. https://doi.org/10.1016/j.clineuro.2020.105972.
Cohen-Jonathan-Moyal, é., V. Vendrely, L. Motte, J. Balosso, and J. Thariat. “Radioresistant Tumours: From Identification to Targeting.” Cancer/Radiothérapie, 2020, S1278321820301669. https://doi.org/10.1016/j.canrad.2020.05.005.
Modesto, A., C. Dalmasso, A. Lusque, L. Vieillevigne, F. Izar, E. Moyal, N. Carrère, R. Guimbaud, and M. Rives. “Tolerance and Efficacy of Dose Escalation Using IMRT Combined with Chemotherapy for Unresectable Esophageal Carcinoma: Long-Term Results of 51 Patients.” Cancer/Radiothérapie 24, no. 2 (2020): 88–92. https://doi.org/10.1016/j.canrad.2020.01.006.
PUBLICATIONS 2019
Deshors, Pauline, Christine Toulas, Florent Arnauduc, Laure Malric, Aurore Siegfried, Yvan Nicaise, Anthony Lemarié, et al. “Ionizing Radiation Induces Endothelial Transdifferentiation of Glioblastoma Stem-like Cells through the Tie2 Signaling Pathway.” Cell Death & Disease 10, no. 11 (October 28, 2019): 816. https://doi.org/10.1038/s41419-019-2055-6.
Bayart, E., D. Azria, J. Balosso, M. Benderitter, E. Cohen-Jonathan Moyal, G. Delpon, E. Deutsch, et al. “[RadioTransNet, the French network for preclinical research in oncological radiotherapy].” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique, August 24, 2019. https://doi.org/10.1016/j.canrad.2019.07.155.
Dauzier, Etienne, Benjamin Lacas, Pierre Blanchard, Quynh-Thu Le, Christian Simon, Gregory Wolf, François Janot, et al. “Role of Chemotherapy in 5000 Patients with Head and Neck Cancer Treated by Curative Surgery: A Subgroup Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer.” Oral Oncology 95 (August 2019): 106–14. https://doi.org/10.1016/j.oraloncology.2019.06.001.
Mouly, Laetitia, Julia Gilhodes, Anthony Lemarié, Elizabeth Cohen-Jonathan Moyal, Christine Toulas, Gilles Favre, Olivier Sordet, and Sylvie Monferran. “The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis.” International Journal of Molecular Sciences 20, no. 15 (July 24, 2019). https://doi.org/10.3390/ijms20153612.
Modesto, A., C. Chira, J.-C. Sol, V. Lubrano, S. Boulinguez, C. Pagès, V. Sibaud, C. Gomez-Roca, É Moyal, and N. Meyer. “[Treatment of patients with brain metastases from a melanoma].” Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique 23, no. 2 (April 2019): 147–50. https://doi.org/10.1016/j.canrad.2018.05.006.
Kowalski-Chauvel, Aline, Valerie Gouaze-Andersson, Laurent Baricault, Elodie Martin, Caroline Delmas, Christine Toulas, Elizabeth Cohen-Jonathan-Moyal, and Catherine Seva. “Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness.” Cancers 11, no. 3 (March 22, 2019). https://doi.org/10.3390/cancers11030406.
Laprie, Anne, Soléakhéna Ken, Thomas Filleron, Vincent Lubrano, Laure Vieillevigne, Fatima Tensaouti, Isabelle Catalaa, et al. “Dose-Painting Multicenter Phase III Trial in Newly Diagnosed Glioblastoma: The SPECTRO-GLIO Trial Comparing Arm A Standard Radiochemotherapy to Arm B Radiochemotherapy with Simultaneous Integrated Boost Guided by MR Spectroscopic Imaging.” BMC Cancer 19, no. 1 (February 21, 2019): 167. https://doi.org/10.1186/s12885-019-5317-x.
De Barros, Amaury, Justine Attal, Margaux Roques, Julien Nicolau, Jean-Christophe Sol, Elizabeth Cohen-Jonathan-Moyal, and Franck-Emmanuel Roux. “Impact on Survival of Early Tumor Growth between Surgery and Radiotherapy in Patients with de Novo Glioblastoma.” Journal of Neuro-Oncology, February 19, 2019. https://doi.org/10.1007/s11060-019-03120-3.
Malric, Laure, Sylvie Monferran, Caroline Delmas, Florent Arnauduc, Perrine Dahan, Sabrina Boyrie, Pauline Deshors, et al. “Inhibiting Integrin Β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells.” Molecular Cancer Research: MCR 17, no. 2 (2019): 384–97. https://doi.org/10.1158/1541-7786.MCR-18-0386.

LES MEMBRES DE L’ÉQUIPE

Anouchka Modesto
Clinicien Chercheur / Researcher hospital practitioner
Emmanuelle Uro-Coste
Hospitalo-Universitaire / University teacher hospital practitioner
Clément Peux
Master / Master student
Luc Simon
Clinicien Chercheur / Researcher hospital practitioner
Solène Evrard
Enseignant chercheur / University researcher
Laurent Baricault
Enseignant chercheur / University researcher
Anthony Lemarié
Enseignant chercheur / University researcher
Hugo Théveniaut
Chercheur Post-Doctorant / Post-Doc researcher
Monique Courtade-Saïdi
Hospitalo-Universitaire / University teacher hospital practitioner
Elizabeth Moyal
Hospitalo-Universitaire / University teacher hospital practitioner
Laure Vieillevigne
Enseignant chercheur / University researcher
Tom Maillet
Doctorant / PhD student
Alexia Delbaere
Doctorant / PhD student
Valérie Gouaze-Andersson
Chercheur statutaire / permanent scientist
Sheraz Blas
Doctorant / PhD student
Pauline Deshors
Chercheur Post-Doctorant / Post-Doc researcher
Yvan Nicaise
Technicien de laboratoire / Laboratory Technician
Florent Arnauduc
Technicien de laboratoire / Laboratory Technician
Catherine Seva
Chercheur statutaire / permanent scientist
Aurianne Hagimont
Technicien de laboratoire / Laboratory Technician

LES PARTENAIRES & FINANCIERS

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse – FR

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