Équipe
maha ayyoub

T2i :

Immunité anti-tumorale et immunothérapie

Les spécificités

de notre axe de recherche

Lymphocytes T spécifique des antigènes tumoraux

Épuisement des lymphocytes T

Immunothérapie par inhibiteurs des points de contrôle immunitaire

Vaccins anti-cancer

Essais cliniques

Modèles précliniques orthotopiques

Génomique

Trancriptomique

DES PROJETS
DE RECHERCHE

En live

PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2021
Cerapio, Juan-Pablo, Marion Perrier, Camille-Charlotte Balança, Pauline Gravelle, Fréderic Pont, Christel Devaud, Don-Marc Franchini, et al. “Phased Differentiation of Γδ T and T CD8 Tumor-Infiltrating Lymphocytes Revealed by Single-Cell Transcriptomics of Human Cancers.” Oncoimmunology 10, no. 1 (2021): 1939518. https://doi.org/10.1080/2162402X.2021.1939518.
Khalifa, Jonathan, Julien Mazieres, Carlos Gomez-Roca, Maha Ayyoub, and Elizabeth Cohen-Jonathan Moyal. “Radiotherapy in the Era of Immunotherapy With a Focus on Non-Small-Cell Lung Cancer: Time to Revisit Ancient Dogmas?” Frontiers in Oncology 11 (2021): 662236. https://doi.org/10.3389/fonc.2021.662236.
PUBLICATIONS 2020
Balança, Camille-Charlotte, Anna Salvioni, Clara-Maria Scarlata, Marie Michelas, Carlos Martinez-Gomez, Carlos Gomez-Roca, Victor Sarradin, et al. “PD-1 Blockade Restores Helper Activity of Tumor-Infiltrating Exhausted PD-1hiCD39+ CD4 T Cells.” JCI Insight, December 17, 2020. https://doi.org/10.1172/jci.insight.142513.
Montfort, Anne, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhès, Cécile Pages, Pascale Olivier, et al. “Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase 1b Clinical Trial.” Clinical Cancer Research, December 3, 2020, clincanres.3449.2020. https://doi.org/10.1158/1078-0432.CCR-20-3449.
Weulersse, Marianne, Assia Asrir, Andrea C. Pichler, Lea Lemaitre, Matthias Braun, Nadege Carrie, Marie-Veronique Joubert, et al. “Eomes-Dependent Loss of the Co-Activating Receptor CD226 Restrains CD8(+) T Cell Anti-Tumor Functions and Limits the Efficacy of Cancer Immunotherapy.” Immunity 53, no. 4 (October 13, 2020): 824-839.e10. https://doi.org/10.1016/j.immuni.2020.09.006.
Fluckiger, Aurélie, Romain Daillère, Mohamed Sassi, Barbara Susanne Sixt, Peng Liu, Friedemann Loos, Corentin Richard, et al. “Cross-Reactivity between Tumor MHC Class I-Restricted Antigens and an Enterococcal Bacteriophage.” Science (New York, N.Y.) 369, no. 6506 (August 21, 2020): 936–42. https://doi.org/10.1126/science.aax0701.
Trimaglio, Giulia, Anne-Françoise Tilkin-Mariamé, Virginie Feliu, Françoise Lauzéral-Vizcaino, Marie Tosolini, Carine Valle, Maha Ayyoub, et al. “Colon-Specific Immune Microenvironment Regulates Cancer Progression versus Rejection.” Oncoimmunology 9, no. 1 (July 12, 2020): 1790125. https://doi.org/10.1080/2162402X.2020.1790125.
Martinez, Alejandra, Jean-Pierre Delord, Maha Ayyoub, and Christel Devaud. “Preclinical and Clinical Immunotherapeutic Strategies in Epithelial Ovarian Cancer.” Cancers 12, no. 7 (July 2, 2020): 1761. https://doi.org/10.3390/cancers12071761.
Balança, Camille-Charlotte, Clara-Maria Scarlata, Marie Michelas, Christel Devaud, Victor Sarradin, Camille Franchet, Carlos Martinez Gomez, et al. “Dual Relief of T-Lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies.” Cancer Immunology Research 8, no. 7 (July 2020): 869–82. https://doi.org/10.1158/2326-6066.CIR-19-0855.
Pont, Frédéric, Marie Tosolini, Qing Gao, Marion Perrier, Miguel Madrid-Mencía, Tse Shun Huang, Pierre Neuvial, Maha Ayyoub, Kristopher Nazor, and Jean-Jacques Fournié. “Single-Cell Virtual Cytometer Allows User-Friendly and Versatile Analysis and Visualization of Multimodal Single Cell RNAseq Datasets.” NAR Genomics and Bioinformatics 2, no. 2 (June 1, 2020): lqaa025. https://doi.org/10.1093/nargab/lqaa025.
Prat, Mélissa, Augustin Le Naour, Kimberley Coulson, Fanny Lemée, Hélène Leray, Godefroy Jacquemin, Mouna Chirine Rahabi, et al. “Circulating CD14 high CD16 low Intermediate Blood Monocytes as a Biomarker of Ascites Immune Status and Ovarian Cancer Progression.” Journal for ImmunoTherapy of Cancer 8, no. 1 (2020): e000472. https://doi.org/10.1136/jitc-2019-000472.
PUBLICATIONS 2019
Montfort, Anne, Carine Dufau, Céline Colacios, Nathalie Andrieu-Abadie, Thierry Levade, Thomas Filleron, Jean-Pierre Delord, Maha Ayyoub, Nicolas Meyer, and Bruno Ségui. “Anti-TNF, a Magic Bullet in Cancer Immunotherapy?” Journal for Immunotherapy of Cancer 7, no. 1 (November 14, 2019): 303. https://doi.org/10.1186/s40425-019-0802-y.
Franchini, Don-Marc, Olivia Lanvin, Marie Tosolini, Emilie Patras de Campaigno, Anne Cammas, Sarah Péricart, Clara-Maria Scarlata, et al. “Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.” Cell Reports 26, no. 1 (January 2, 2019): 94-107.e7. https://doi.org/10.1016/j.celrep.2018.12.014.

LES MEMBRES DE L’ÉQUIPE

Mathieu Ajalbert
Ingénieur ou technicien / Engineer and Technician
Myriam Maixent
Ingénieur ou technicien / Engineer and Technician
Carlos Gomez-Roca
Personnel hospitalier / Hospital Staff
Maha Ayyoub
Enseignant-chercheur / Teacher-researcher
Françoise Lauzeral-Vizcaino
Ingénieur ou technicien / Engineer and Technician
Clara-Maria Scarlata
Ingénieur ou technicien / Engineer and Technician
Anna Salvioni
Chercheur / Researcher
Christel Devaud
Chercheur / Researcher
Victor Sarradin
Etudiant ou stagiaire / PhD student and Trainee
Giulia Costanza Leonardi
Chercheur / Researcher
Virginie Feliu
Ingénieur ou technicien / Engineer and Technician
Lise Scandella
Ingénieur ou technicien / Engineer and Technician
Marie Michelas
Ingénieur ou technicien / Engineer and Technician
Célia Ramade
Etudiant ou stagiaire / PhD student and Trainee
Sylvie Giuriato
Chercheur / Researcher
Noémie Thébault
Ingénieur ou technicien / Engineer and Technician

LES PARTENAIRES & FINANCIERS

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches en Cancérologie de Toulouse (Oncopole)

Toulouse - FR

Nous contacter

05 82 74 15 75

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