Équipe
maha ayyoub
T2i :
Immunité anti-tumorale et immunothérapie
Les spécificités
de notre axe de recherche
Lymphocytes T spécifique des antigènes tumoraux
Épuisement des lymphocytes T
Immunothérapie par inhibiteurs des points de contrôle immunitaire
Vaccins anti-cancer
Essais cliniques
Modèles précliniques orthotopiques
Génomique
Trancriptomique
DES PROJETS
DE RECHERCHE
Rôle des lymphocytes T spécifiques des Ag tumoraux dans la réponse clinique aux immunothérapies
Pr Maha Ayyoub
Mise en place d’essais cliniques et suivi immunitaire des patients traités par immunothérapie
Clara-Maria Scarlata
Ciblage de l’autophagie dans l’immunothérapie anti-cancéreuse
Sylvie Giuriato
Impact des microenvironnements immuns tumoraux sur la réponse aux immunothérapies
Christel Devaud
Complexité immunitaire des cancers épithéliaux
Pr Alejandra Martinez et Dr Anna Salvioni
LES FOCUS
DE L’ÉQUIPE
Découvrir
Comprendre
Participer
En live
;
#Postdoctoral fellow at the #Cancer Research Center, Toulouse, France on the impact of combining #TNF blockade and #immunotherapy on #immune responses and #melanoma liver metastases in #mice.
2 year contract from Nov 1, 2023
Contact bruno.segui@inserm.fr before October 15, 2023.
PRODUCTIONS SCIENTIFIQUES
PUBLICATIONS 2023
Spagnolo, Emanuela, Alejandra Martinez, Andrea Mascarós-Martínez, Josep Marí-Alexandre, María Carbonell, Eva González-Cantó, Eva Manuela Pena-Burgos, et al. “Evaluation of Immune Infiltrates in Ovarian Endometriosis and Endometriosis-Associated Ovarian Cancer: Relationship with Histological and Clinical Features.” International Journal of Molecular Sciences 24, no. 15 (July 28, 2023): 12083. https://doi.org/10.3390/ijms241512083.
Feliu, Virginie, Carlos Gomez-Roca, Marie Michelas, Noémie Thébault, Françoise Lauzéral-Vizcaino, Anna Salvioni, Lise Scandella, et al. “Distant Antimetastatic Effect of Enterotropic Colon Cancer-Derived Α4β7+CD8+ T Cells.” Science Immunology 8, no. 84 (June 2, 2023): eadg8841. https://doi.org/10.1126/sciimmunol.adg8841.
Martínez, Alejandra, Cyrus Chargari, Elsa Kalbacher, Anne-Lise Gaillard, Alexandra Leary, Martin Koskas, Nicolás Chopin, et al. “Recommandations pour la pratique clinique Nice/Saint-Paul-de-Vence 2022–2023 : prise en charge du cancer de l’endomètre localisé.” Bulletin Du Cancer 110, no. 6S (June 2023): 6S20-26S33. https://doi.org/10.1016/S0007-4551(23)00331-4.
Martinez, Alejandra, Fabrice Lecuru, Nicolò Bizzarri, Cyrus Chargari, Anne Ducassou, Anna Fagotti, Francesco Fanfani, et al. “PARa-AOrtic LymphAdenectomy in Locally Advanced Cervical Cancer (PAROLA Trial): A GINECO, ENGOT, and GCIG Study.” International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society, January 30, 2023, ijgc–2022–004223. https://doi.org/10.1136/ijgc-2022-004223.
PUBLICATIONS 2022
Martinez, Alejandra, Berta Díaz-Feijoo, and Denis Querleu. “Para-Aortic Lymphadenectomy in Cervical Cancer Deserves a New Trial.” International Journal of Gynecologic Cancer, September 16, 2022, ijgc–2022–003910. https://doi.org/10.1136/ijgc-2022-003910.
Martinez-Gomez, Carlos, Marie Michelas, Clara-Maria Scarlata, Anna Salvioni, Carlos Gomez-Roca, Victor Sarradin, Françoise Lauzéral-Vizcaino, et al. “Circulating Exhausted PD-1+CD39+ Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade.” Cancers 14, no. 15 (July 28, 2022): 3679. https://doi.org/10.3390/cancers14153679.
Martinez, Alejandra, Elodie Chantalat, Martina Aida Angeles, Gwénaël Ferron, Anne Ducassou, Manon Daix, Justine Attal, Sarah Bétrian, Amélie Lusque, and Erwan Gabiache. “Metabolic Activity Determines Survival Depending on the Level of Lymph Node Involvement in Cervical Cancer.” BMC Cancer 22, no. 1 (July 23, 2022): 810. https://doi.org/10.1186/s12885-022-09785-w.
Angeles, Martina Aida, Alicia Hernández, Asunción Pérez-Benavente, Bastien Cabarrou, Emanuela Spagnolo, Agnieszka Rychlik, Amel Daboussi, et al. “The Effect of Major Postoperative Complications on Recurrence and Long-Term Survival after Cytoreductive Surgery for Ovarian Cancer.” Gynecologic Oncology 166, no. 1 (July 2022): 8–17. https://doi.org/10.1016/j.ygyno.2022.05.002.
Daix, Manon, Carlos Martinez Gomez, Martina Aida Angeles, Stéphanie Tock, Laurence Gladieff, Erwan Gabiache, Eliane Mery, Alejandra Martinez, David Cibula, and Gwénaël Ferron. “Extended Pelvic Resection for Gynecological Malignancies: A Review of out-of-the-Box Surgery.” Gynecologic Oncology, March 21, 2022, S0090-8258(22)00174-3. https://doi.org/10.1016/j.ygyno.2022.03.002.
Daix, Manon, Martina Aida Angeles, Hélène Leray, Kelig Vergriete, Alejandra Martinez, and Gwenael Ferron. “Anterior Pelvic Exenteration and Laterally Extended Pelvic Resection: A Step by Step Procedure.” International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society 32, no. 1 (January 2022): 107–8. https://doi.org/10.1136/ijgc-2021-003047.
PUBLICATIONS 2021
Angeles, Martina Aida, Hélène Leray, Federico Migliorelli, Manon Daix, Alejandra Martinez, and Gwenael Ferron. “Surgical Approach of the Left Upper Quadrant for Ovarian Cancer in 10 Steps.” International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society 31, no. 11 (November 2021): 1488–89. https://doi.org/10.1136/ijgc-2021-002963.
Cerapio, Juan-Pablo, Marion Perrier, Camille-Charlotte Balança, Pauline Gravelle, Fréderic Pont, Christel Devaud, Don-Marc Franchini, et al. “Phased Differentiation of Γδ T and T CD8 Tumor-Infiltrating Lymphocytes Revealed by Single-Cell Transcriptomics of Human Cancers.” Oncoimmunology 10, no. 1 (2021): 1939518. https://doi.org/10.1080/2162402X.2021.1939518.
Khalifa, Jonathan, Julien Mazieres, Carlos Gomez-Roca, Maha Ayyoub, and Elizabeth Cohen-Jonathan Moyal. “Radiotherapy in the Era of Immunotherapy With a Focus on Non-Small-Cell Lung Cancer: Time to Revisit Ancient Dogmas?” Frontiers in Oncology 11 (2021): 662236. https://doi.org/10.3389/fonc.2021.662236.
PUBLICATIONS 2020
Balança, Camille-Charlotte, Anna Salvioni, Clara-Maria Scarlata, Marie Michelas, Carlos Martinez-Gomez, Carlos Gomez-Roca, Victor Sarradin, et al. “PD-1 Blockade Restores Helper Activity of Tumor-Infiltrating Exhausted PD-1hiCD39+ CD4 T Cells.” JCI Insight, December 17, 2020. https://doi.org/10.1172/jci.insight.142513.
Montfort, Anne, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhès, Cécile Pages, Pascale Olivier, et al. “Combining Nivolumab and Ipilimumab with Infliximab or Certolizumab in Patients with Advanced Melanoma: First Results of a Phase 1b Clinical Trial.” Clinical Cancer Research, December 3, 2020, clincanres.3449.2020. https://doi.org/10.1158/1078-0432.CCR-20-3449.
Weulersse, Marianne, Assia Asrir, Andrea C. Pichler, Lea Lemaitre, Matthias Braun, Nadege Carrie, Marie-Veronique Joubert, et al. “Eomes-Dependent Loss of the Co-Activating Receptor CD226 Restrains CD8(+) T Cell Anti-Tumor Functions and Limits the Efficacy of Cancer Immunotherapy.” Immunity 53, no. 4 (October 13, 2020): 824-839.e10. https://doi.org/10.1016/j.immuni.2020.09.006.
Fluckiger, Aurélie, Romain Daillère, Mohamed Sassi, Barbara Susanne Sixt, Peng Liu, Friedemann Loos, Corentin Richard, et al. “Cross-Reactivity between Tumor MHC Class I-Restricted Antigens and an Enterococcal Bacteriophage.” Science (New York, N.Y.) 369, no. 6506 (August 21, 2020): 936–42. https://doi.org/10.1126/science.aax0701.
Trimaglio, Giulia, Anne-Françoise Tilkin-Mariamé, Virginie Feliu, Françoise Lauzéral-Vizcaino, Marie Tosolini, Carine Valle, Maha Ayyoub, et al. “Colon-Specific Immune Microenvironment Regulates Cancer Progression versus Rejection.” Oncoimmunology 9, no. 1 (July 12, 2020): 1790125. https://doi.org/10.1080/2162402X.2020.1790125.
Martinez, Alejandra, Jean-Pierre Delord, Maha Ayyoub, and Christel Devaud. “Preclinical and Clinical Immunotherapeutic Strategies in Epithelial Ovarian Cancer.” Cancers 12, no. 7 (July 2, 2020): 1761. https://doi.org/10.3390/cancers12071761.
Balança, Camille-Charlotte, Clara-Maria Scarlata, Marie Michelas, Christel Devaud, Victor Sarradin, Camille Franchet, Carlos Martinez Gomez, et al. “Dual Relief of T-Lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies.” Cancer Immunology Research 8, no. 7 (July 2020): 869–82. https://doi.org/10.1158/2326-6066.CIR-19-0855.
Pont, Frédéric, Marie Tosolini, Qing Gao, Marion Perrier, Miguel Madrid-Mencía, Tse Shun Huang, Pierre Neuvial, Maha Ayyoub, Kristopher Nazor, and Jean-Jacques Fournié. “Single-Cell Virtual Cytometer Allows User-Friendly and Versatile Analysis and Visualization of Multimodal Single Cell RNAseq Datasets.” NAR Genomics and Bioinformatics 2, no. 2 (June 1, 2020): lqaa025. https://doi.org/10.1093/nargab/lqaa025.
Prat, Mélissa, Augustin Le Naour, Kimberley Coulson, Fanny Lemée, Hélène Leray, Godefroy Jacquemin, Mouna Chirine Rahabi, et al. “Circulating CD14 high CD16 low Intermediate Blood Monocytes as a Biomarker of Ascites Immune Status and Ovarian Cancer Progression.” Journal for ImmunoTherapy of Cancer 8, no. 1 (2020): e000472. https://doi.org/10.1136/jitc-2019-000472.
PUBLICATIONS 2019
Montfort, Anne, Carine Dufau, Céline Colacios, Nathalie Andrieu-Abadie, Thierry Levade, Thomas Filleron, Jean-Pierre Delord, Maha Ayyoub, Nicolas Meyer, and Bruno Ségui. “Anti-TNF, a Magic Bullet in Cancer Immunotherapy?” Journal for Immunotherapy of Cancer 7, no. 1 (November 14, 2019): 303. https://doi.org/10.1186/s40425-019-0802-y.
Franchini, Don-Marc, Olivia Lanvin, Marie Tosolini, Emilie Patras de Campaigno, Anne Cammas, Sarah Péricart, Clara-Maria Scarlata, et al. “Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells.” Cell Reports 26, no. 1 (January 2, 2019): 94-107.e7. https://doi.org/10.1016/j.celrep.2018.12.014.
LES MEMBRES DE L’ÉQUIPE
LES PARTENAIRES & FINANCIERS
Centre de Recherches en Cancérologie de Toulouse (Oncopole)
Toulouse – FR
CRCT-Oncopole Follow 1,220 1,117
Compte officiel du Centre de Recherches en Cancérologie de Toulouse
Castelnau-Montratier célèbre la lutte contre le cancer. Jeudi 24 août 2023 conférence avec Frédéric Chibon responsable de l'équipe @OncoSarc du @crctoncopole accompagné de Gwenaël Ferron et Martin Gauthier oncologue @IUCTOncopole
Découvrir l'équipe
➡️https://www.crct-inserm.fr/oncosarc/
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05 82 74 15 75
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