Pr Camille Laurent

Identification of immuno-escape mechanisms by multiomics approaches.

Our work focuses on the innate and adaptive immune response in lymphoma with a special mention on the study of Tγδ lymphocytes and mechanisms of regulation of immune checkpoint expression.Recently, we have introduced Single Cell RNAseq techniques includint spatial transcriptomic analyses and developed bionformatic tools allowing us to explore the functional status and maturation/differentiation stage of cytotoxic effectors at the single cell scale in samples lymph nodes or blood of patients with lymphoma.Privileged access to different cohorts of lymphoma patients has also allowed us to identify biomarkers of response in lymphomas and the establishment of a screening platform in 3D models from patient samples lymphomas.

Parternships and funding:

 

The NoLymIT team is a partner of BIALYMPH in the European research program TRANSCAN, coordinated by Dr Wolfgang Huber and including five research teams:

• UKHD Heidelberg,
• two Inserm teams (MOBIDIC from Université de Rennes/Inserm and NoLymIT from CRCT),
  University of Palermo 
• Eotvos Lorand Research Network & Biological Research Centre.

The objective is to identify patients with follicular B lymphoma who may or may not respond to bispecific antibodies.
The NoLymIT team will characterize immuno-escape mechanisms using multi-omics approaches in the lymph nodes of FL patients from the various clinical
trials of the three major European cooperative groups:

• German Lymphoma Alliance (GLA),
• French Lymphoma Study Association (LYSA),
• Italian Lymphoma Foundation (FIL).