team
mARC POIROT & SANDRINE SILVENTE-POIROT
INOV :
Cholesterol Metabolism and
Therapeutic Innovations
Team labelled Ligue contre le Cancer
THE SPECIFICITIES
OF OUR RESEARCH AXIS
We explore the role of cholesterol metabolism in the control of tumor progression and in the resistance to therapies in several cancers (breast, skin, thyroid, leukemia). We are studying the biological properties and biosynthetic pathways of two metabolites that we have discovered: dendrogenin A (DDA) and oncosterone (OCDO) which are respectively tumor suppressor and tumor promoter metabolites. The ultimate goal of these studies is to develop new drug candidates and theranostic tools for new targeted and personalized cancer therapies. They will also define the role of the sterol component of the diet on the development of certain cancers.
Our Webinars
LIPID MAPS Webinar – Dr Marc Poirot – 28.03.2023: Recent discoveries on the cholesterol metabolic pathway: the 5,6-epoxycholesterol branch, dendrogenins and oncosterone
International society for extracellular vesicles: 31.05.2023: Immunogenic EVs in cancer
La recherche s’intéresse à mon assiette : 20.09.2023 : Relations entre alimentation et maladies dégénératives : le cas du cholesterol
réseau Nutrition Alimentation, activité physique, recherche (NACRe): WebiNACRe n°11, 4rth july 2024: Cholesterol et cancer
oncometabolism
cholesterol
oxysterol
oncosterone
secretory vesicles
exosomes
dendrogenin
nuclear receptors
enzymes
metabolic imaging
research projects
Oxysterols, lipid metabolism and nuclear receptors
Dr Marc Poirot
New metabolic pathway and tumor development
Dr Philippe De Medina
Studies of the signaling pathways activated by oncosterone and dendrogenin a
Dr Sandrine Silvente-Poirot
New probes for non-invasive tumor detection by medical imaging
Dr. Philippe De Medina & Pr. Frédéric Courbon
Studies of deregulation of cholesterol metabolism in neuroendocrine cancers
Dr. Lavinia Vija
THE TEAM’S
FOCUS
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SCIENTIFIC PRODUCTIONS
PUBLICATIONS 2026
PUBLICATIONS 2025
PUBLICATIONS 2024
PUBLICATIONS 2023
PUBLICATIONS 2022
PUBLICATIONS 2021
PUBLICATIONS 2020
PUBLICATIONS 2019
TEAM MEMBERS
PARTERNSHIPS & FUNDING
Toulouse Cancer Research Center (Oncopole)
Toulouse - FR
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Contact us
+33 5 82 74 15 75
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the CRCT team ?
