Morphometric analysis of neoplastic cell clusters in high-grade serous ovarian cancer ascites identifies a promising prognostic factor: a retrospective study

29 Apr 2025 | Discover home page, Discover SigDyn

Morphometric analysis of neoplastic cell clusters in high-grade serous ovarian cancer ascites identifies a promising prognostic factor: a retrospective study. Ovarian cancer, Ascites, Cell clustering, Peritoneal disease, Prognostic factor, Cytomorphology,...

Mechanical stress on solid cancer development

15 Apr 2025 | Discover home page, Discover SigDyn

Mechanical stress on solid cancer development Mechanobiology, compression, PancreaticCancer, breastcancer, PI3K, autophagy. DI-LUOFFO Mickael – SigDyn – : Integrated cellular signalling and PI3K isoforms This study provides direct evidence for the role of...

The PI3K alpha inhibition sensitizes ovarian cancer with PIK3CA mutation to conventional chemotherapy

13 Mar 2025 | Discover home page, Discover SigDyn

The PI3K alpha inhibition sensitizes ovarian cancer with PIK3CA mutation to conventional chemotherapy PI3K signalling, Tumour cell aggregates, Resistance to treatment, Signal-targeted therapies, BYL-719/Alpelisib, Cisplatin, Combination therapy, Mesenchymal stem...

Role of Vps34, presentation at the 2nd Young Scientist Cancer Congress

23 Jan 2025 | Discover home page, Discover SigDyn

Role of Vps34, presentation at the 2nd Young Scientist Cancer Congress  The 2nd Young Scientist Cancer Congress took place on 10-11th October in Montpellier, as an initiative to promote the careers of young scientists and clinicians. Hala Shalhoub, post-doc in the...

New publication on Autophagy

7 Jun 2024 | Discover home page, Discover SigDyn

New publication on Autophagy Liver cancer chloroquine cholangio carcinoma therapy microbial metabolite cell death butyrate, oxidative stress Hala Shalhoub – Equipe SigDyn – Integrated cellular signalling and PI3K isoforms Our cells can eat itself through a...

Focus research 2022 SigDyn team

30 Sep 2023 | Discover SigDyn

Focus research 2022 SigDyn team Cross-regulation between PI3Ks Can they be used to better prevent tumor progression?PI3Ks are a family of three classes of enzymes essential to cell life and which are frequently deregulated in cancer. The dependence of tumors on...