Équipe
SALVATORE VALITUTTI
DynAct :
Dynamique moléculaire des interactions lymphocytaires
L’équipe fait partie du consortium « ATTACK Cancer » financé par un ERC Synergy Grant, visant à mettre au point des traitements anticancéreux plus efficaces et plus ciblés.
Le laboratoire d’Excellence Toulouse Cancer est un projet qui vise à comprendre les mécanismes de résistance et de rechute dans les cancers.
Les spécificités
de notre axe de recherche
Les réponses immunitaires sont basées sur des interactions multiples et dynamiques entre les cellules du système immunitaire conduisant à la formation de zones de signalisation spécialisées, les synapses immunologiques.
Notre équipe applique une combinaison d’approches de pointe, incluant l’imagerie des cellules vivantes rapide et la microscopie de super-résolution (sur des cellules isolées et des tranches de tissus humains) mais également la modélisation mathématique, de manière à visualiser et interpréter les dynamiques moléculaires se produisant au niveau des synapses immunologiques. Décrypter la communication intercellulaire au niveau des synapses immunologiques peut contribuer à concevoir des stratégies thérapeutiques innovantes visant à moduler les réponses immunitaires dans différents contextes pathologiques.
Synapse immunologique
Lymphocytes T cytotoxiques
Immunologie tumorale
Techniques d’imagerie en temps réel
Immuno-évasion tumorale
Pyroptose
Biologie computationnelle
Modélisation in silico
Vision par ordinateur
Programmation génétique cartésienne
T CD8+ mémoire-résidents
Microenvironement tumoral
DES PROJETS
DE RECHERCHE
La lutte entre lymphocytes T cytotoxiques et cellules tumorales à la synapse lytique
Dr Salvatore Valitutti
Modélisation et “computer vision” appliquées à l’étude des interactions compétitives CTL/cellules cibles
Salvatore Valitutti & Sylvain Cussat-Blanc
Fonction et Régulation des lymphocytes T CD8+ mémoire-résidents
Fanny Lafouresse
Étude de la pyroptose des cellules cibles dans le contexte de la mort induite par les CTL
Dr Brienne Mckenzie
Déchiffrer l’hétérogénéité fonctionnelle des lymphocytes T cytotoxiques dans le cancer
Roxana Khazen
LES FOCUS
DE L’ÉQUIPE
Découvrir
Comprendre
Participer
En live
;
We're hiring a talented postdoc to join us at CRCT (Toulouse, FR) in a context of a ERC Synergy Grant to investigate the functional signatures of CD8+ cytotoxic T cells in cancer. https://euraxess.ec.europa.eu/jobs/335595
PRODUCTIONS SCIENTIFIQUES
PUBLICATIONS 2025
7813506
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2025
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Leveque, Edouard, Régis Joulia, Louise Battut, Camille Laurent, Salvatore Valitutti, Nicolas Cénac, Gilles Dietrich, and Eric Espinosa. “Mast Cells Promote Inflammatory Th17 Cells and Impair Treg Cells Through an IL-1β and PGE2 Axis.” Journal of Inflammation Research 18 (2025): 5851–65. https://doi.org/10.2147/JIR.S509931.
PUBLICATIONS 2024
7813506
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2024
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Zevolini, Fabrizia, Anna Onnis, Roxana Khazen, Sabina Müller, Giuseppe Marotta, Salvatore Valitutti, Francesca Finetti, and Cosima T. Baldari. “Polo-like Kinase 1 Regulates Immune Synapse Assembly and Cytotoxic T Cell Function by Driving Microtubule Dynamics.” Journal of Cell Science 137, no. 5 (March 1, 2024): jcs261476. https://doi.org/10.1242/jcs.261476.
Battut, Louise, Edouard Leveque, Salvatore Valitutti, Nicolas Cenac, Gilles Dietrich, and Eric Espinosa. “IL-33-Primed Human Mast Cells Drive IL-9 Production by CD4+ Effector T Cells in an OX40L-Dependent Manner.” Frontiers in Immunology 15 (2024): 1470546. https://doi.org/10.3389/fimmu.2024.1470546.
PUBLICATIONS 2023
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Baldari, Cosima T., Salvatore Valitutti, and Michael L. Dustin. “Editorial: Mechanisms of Lymphocyte Mediated Cytotoxicity in Health and Disease.” Frontiers in Immunology 14 (2023): 1226870. https://doi.org/10.3389/fimmu.2023.1226870.
Müller, Sabina, Liza Filali, Marie-Pierre Puissegur, and Salvatore Valitutti. “Measuring CTL Lytic Granule Secretion and Target Cell Membrane Repair by Fluorescent Lipophilic Dye Uptake at the Lytic Synapse.” Methods in Molecular Biology (Clifton, N.J.) 2654 (2023): 463–76. https://doi.org/10.1007/978-1-0716-3135-5_30.
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Laplagne, Chloé, Laetitia Ligat, Juliet Foote, Frederic Lopez, Jean-Jacques Fournié, Camille Laurent, Salvatore Valitutti, and Mary Poupot. “Self-Activation of Vγ9Vδ2 T Cells by Exogenous Phosphoantigens Involves TCR and Butyrophilins.” Cellular & Molecular Immunology, June 28, 2021. https://doi.org/10.1038/s41423-021-00720-w.
Lafouresse, Fanny, Romain Jugele, Sabina Müller, Marine Doineau, Valérie Duplan-Eche, Eric Espinosa, Marie-Pierre Puisségur, Sébastien Gadat, and Salvatore Valitutti. “Stochastic Asymmetric Repartition of Lytic Machinery in Dividing CD8+ T Cells Generates Heterogeneous Killing Behavior.” eLife 10 (January 11, 2021): e62691. https://doi.org/10.7554/eLife.62691.
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Khazen, Roxana, Sabina Müller, Fanny Lafouresse, Salvatore Valitutti, and Sylvain Cussat-Blanc. “Sequential Adjustment of Cytotoxic T Lymphocyte Densities Improves Efficacy in Controlling Tumor Growth.” Scientific Reports 9, no. 1 (August 23, 2019): 12308. https://doi.org/10.1038/s41598-019-48711-2.
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Gonnord, Pauline, Manon Costa, Arnaud Abreu, Michael Peres, Loïc Ysebaert, Sébastien Gadat, and Salvatore Valitutti. “Multiparametric Analysis of CD8+ T Cell Compartment Phenotype in Chronic Lymphocytic Leukemia Reveals a Signature Associated with Progression toward Therapy.” Oncoimmunology 8, no. 4 (2019): e1570774. https://doi.org/10.1080/2162402X.2019.1570774.
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