Équipe
Pierre Cordelier

ImPact :

Innovation thérapeutique dans le cancer du pancréas

Les spécificités

de notre axe de recherche

Le cancer du pancréas, ou adénocarcinome pancréatique, deviendra bientôt la seconde cause de décès par cancer dans le monde, en raison d’un diagnostic tardif et de l’absence de traitements efficaces. Notre effort de recherche est consacré à la mise en place de nouvelles stratégies anticancéreuses afin d’améliorer la prise en charge des patients atteints de ce cancer.

Dans ce contexte, notre objectif de recherche est de mieux comprendre les mécanismes d’oncogenèse et de résistance thérapeutique dans ce cancer. Plus particulièrement, nous étudions le rôle du remodelage et de la réplication du génome dans l’expression génique et la résistance aux agents provoquant des cassures de l’ADN (Projet 1). Nous étudions les protéines et les interactions protéines-protéines impliquées dans l’oncogenèse pancréatique et la résistance au traitement à l’aide d’anticorps intracellulaires (Projet 2). Enfin, nous recherchons les mécanismes responsables de la résistance des cellules cancéreuses aux virus oncolytiques, et étudions l’impact de ces virus sur la réponse immunitaire antitumorale (Projet 3).

Dans son ensemble, ce projet de recherche a pour objectif de traduire nos découvertes de recherche fondamentale en innovations thérapeutiques tangibles pour les patients atteints de cancer du pancréas, selon une approche de médecine de précision.

Cancer du Pancréas

Oncogenèse

Résistance

Thérapies innovantes

Régulation de l’expression génique

Interaction protéine-protéine

Anticorps intracellulaire

Virus oncolytiques

Thérapie génique

Immunothérapie

interdisciplinarité

DES PROJETS
DE RECHERCHE

LES FOCUS
DE L’ÉQUIPE

Découvrir

Une nouvelle technologie très sensible pour détecter rapidement des mutations du récepteur de l’EGF

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Rendre les cellules cancéreuses du pancréas plus vulnérables en ciblant un processus lié à la production d’énergie dans les mitochondries, dépendante d’une enzyme appelée cytidine désaminase

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Seconde saison des Apprentis Chercheurs au CRCT

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L’E3 ubiquitine ligase TRIP12 est nécessaire à la plasticité des cellules acineuses pancréatiques et à au développement du cancer du pancréas.

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Un virus oncolytique qui cible spécifiquement les cellules cancéreuses pancréatiques les plus agressives

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12345

Comprendre

Éradiquer le cancer par thérapie génique : espoir ou utopie ?

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10 ans de recherche contre le Cancer : Toulouse au cœur de la lutte

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La cellule tumorale

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L’immunothérapie en cancérologie

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Les thérapies ciblées en cancérologie

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Participer

TOW2025 J-30 inscription anticipée

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Recherche sur le cancer du pancréas : le projet FRAP sélectionné par l’INCa

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L’équipe ImPact obtient la prestigieuse labellisation de la Fondation ARC pendant 3 ans

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123

En live

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PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2025
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Teillet, Jeffrey, Anne Pradines, Naima Hanoun, Jules Edwards, Pierre Joseph, Anne-Marie Gué, Aurélien Bancaud, and Pierre Cordelier. “Detection of EGFR Mutations at pM Concentration in Ten Minutes Using a Microfluidic Concentration and Separation Module.” Biomedical Microdevices 27, no. 3 (August 28, 2025): 40. https://doi.org/10.1007/s10544-025-00767-w.
Redouté, Agathe, Nikolaos Kontopoulos, Stéphane Bertagnoli, and Pierre Cordelier. “[Oncolytic viruses for the management of pancreatic cancer: ongoing trials and therapeutic perspectives].” Virologie (Montrouge, France) 29, no. 4 (August 19, 2025): 293–311. https://doi.org/10.1684/vir.2025.1100.
Cordelier, Pierre. “Unveiling the Nexus: Oncolytic Viruses, Extracellular Vesicles, and Immune Modulation.” Molecular Therapy. Oncology 33, no. 1 (March 20, 2025): 200940. https://doi.org/10.1016/j.omton.2025.200940.
PUBLICATIONS 2024
7813506 6BDVTCJV 2024 1 chicago-fullnote-bibliography 50 date desc 35723 https://www.crct-inserm.fr/wp-content/plugins/zotpress/
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PUBLICATIONS 2021
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PUBLICATIONS 2019
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Diaz-Riascos, Zamira Vanessa, Mireia M. Ginesta, Joan Fabregat, Teresa Serrano, Juli Busquets, Louis Buscail, Pierre Cordelier, and Gabriel Capellá. “Expression and Role of MicroRNAs from the miR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer.” Molecular Therapy. Nucleic Acids 17 (June 29, 2019): 491–503. https://doi.org/10.1016/j.omtn.2019.06.015.
Buscail, Etienne, Charlotte Maulat, Fabrice Muscari, Laurence Chiche, Pierre Cordelier, Sandrine Dabernat, Catherine Alix-Panabières, and Louis Buscail. “Liquid Biopsy Approach for Pancreatic Ductal Adenocarcinoma.” Cancers 11, no. 6 (June 19, 2019). https://doi.org/10.3390/cancers11060852.
Dromain, Clarisse, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin, Martyn E. Caplin, and CLARINET Study Group. “Tumor Growth Rate as a Metric of Progression, Response, and Prognosis in Pancreatic and Intestinal Neuroendocrine Tumors.” BMC Cancer 19, no. 1 (January 14, 2019): 66. https://doi.org/10.1186/s12885-018-5257-x.
Cacheux, Jean, Aurélien Bancaud, Thierry Leichlé, and Pierre Cordelier. “Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer.” Frontiers in Chemistry 7 (2019): 815. https://doi.org/10.3389/fchem.2019.00815.

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Manon Gervais
Master / Master student
Aurélie GOMES
Ingénieur de laboratoire / laboratory engineer
Léa Badin
Ingénieur de laboratoire / laboratory engineer
Noémie Delenclos
Ingénieur de laboratoire / laboratory engineer
Margot Cristol
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Laura Jouvin
Doctorant / PhD student
Nina Suarez
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Jean Cacheux
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Alban Ricard
Doctorant / PhD student
Damien Varry
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Barbara Bournet
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Nicolas Carrère
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Charlotte Maulat
Doctorant / PhD student
Louis Buscail
Hospitalo-Universitaire / University teacher hospital practitioner
Fabrice Muscari
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Jérôme Torrisani
Chercheur statutaire / permanent scientist
Pierre Cordelier
Chercheur statutaire / permanent scientist
Marie Sorbara
Doctorant / PhD student
Naïma Hanoun-Ziane
Ingénieur de laboratoire / laboratory engineer
Nicolas Béry
Chercheur statutaire / permanent scientist

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Rôle du remodelage et de la réplication du génome dans l’expression génique et la résistance thérapeutique
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Mécanismes d’infection par les virus oncolytiques et nouvelles approches d’immunothérapie
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