The regulation of mRNA translation by RNA G-quadruplex structures contributes to cancer progression and resistance to treatment



traduction d’ARNm,

 RNA G-Quadruplex,

 RNA-binding proteinsG-quadruplexe ARN.

Anne CammasRNAreg Team’s – RNA-Binding Proteins and Genotoxic Stress

Translational reprogramming in response to oncogenic signaling or microenvironmental stress factors shapes the proteome of cancer cells, enabling adaptation and phenotypic changes underlying cell plasticity, tumor progression and response to cancer therapy. Among the mechanisms regulating translation are RNA G-quadruplexes (RG4s), non-canonical four-stranded structures whose conformational modulation by small molecule ligands and RNA-binding proteins affects the expression of cancer proteins. Here, we discuss the role of RG4s in the regulation of mRNA translation by focusing on paradigmatic examples showing their contribution to adaptive mechanisms of mRNA translation in cancer.

Discover the published article

NAR Cancer. 2024 May 31;6(2):zcae025.doi: 10.1093/narcan/zcae025. eCollection 2024 Jun.
The shaping of mRNA translation plasticity by RNA G-quadruplexes in cancer progression and therapy resistance
Anne Cammas, Alice Desprairies , Erik Dassi, Stefania Millevoi
PMID: 38828391  PMCID: PMC11140630  DOI: 10.1093/narcan/zcae025

Collaborations and partnerships

  • The Ministère de l’Éducation Nationale de la Recherche et de Technologie [to AD];

  • Fondation pour la recherche médicale [to AD];

  • Association pour la Recherche sur le Cancer [to S.M.],

  • Ligue contre le cancer [to S.M.];

  • Cancérôpole Grand Sud-Ouest [to S.M.].


Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches contre le Cancer de Toulouse (Oncopole)

Toulouse - FR

Nous contacter

+33 5 82 74 15 75

Nous rejoindre ?

Pin It on Pinterest