Rapid detection of a cancer biomarker by a microfluidic chip

Researchers at LAAS-CNRS, in collaboration with the Toulouse Cancer Research Centre, have shown how the μLAS microfluidic chip technology can concentrate and measure cancer biomarker microRNAs in less than a minute.

MicroRNAs (miRs) are short fragments of RNA that play a role in gene expression. Their concentration is strongly altered in cancer patients, which is why miRs are a target of choice for diagnosis and monitoring of patients, provided that a detection and measurement method is sufficiently sensitive and rapid to be used clinically. Researchers at​ LAAS-CNRS, in collaboration with the Toulouse Cancer Research Centre, have made an important breakthrough in this direction, by achieving the detection of miR-21 in less than one minute using a microfluidic chip. These results are published in the journal Biosensors and Bioelectronics.

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A) Diagram of the µLAS technology. In a funnel-shaped microfluidic channel, the flows are controlled with a hydrodynamic flow (v0) and an opposing electrophoretic velocity (VE). This action specifically concentrates the complex formed by miR-21 associated with a fluorescent reporter (MB) and removes the reporter alone. (B) The left panel shows an optical photograph of the funnel (scale bars correspond to 200 microns). The two images on the right correspond to fluorescence microscopy images with the initial condition (hydrodynamic field alone, top panel) and simultaneous electric field after 30 seconds of concentration (bottom panel) © Aurélien Bancaud, LAAS-CNRS

Discover the published article​

Micro-RNA 21 detection with a limit of 2 pM in 1 min using a size-accordable concentration module operated by electrohydrodynamic actuation
I. Tijunelyte, R. Malbec, B. Chami, J. Cacheux, C. Dez, T. Leichlé, P. Cordelier, A. Bancaud.
Biosensors and Bioelectronics Volume 178, 15 April 2021
DOI: 10.1016/j.bios.2021.112992

Centre de Recherches en Cancérologie de Toulouse

Toulouse Cancer Research Center (Oncopole)

Toulouse – FR

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