Deregulation of protein synthesis in pancreatic cancer
Integrated stress Response (ISR)
Yvan Martineau, Team MICROPANC – Microenvironnement and Therapeutic Resistance in Pancreatic Neoplasms
During the last decade, the deregulation of the protein synthesis process in pancreatic cancer has been widely documented. This process impacts on the initiation, development and follow-up of pancreatic cancer. This review of the literature summarizes the different protein synthesis abnormalities described in pancreatic cancer, which lead to its resistance and adaptation to treatment. We also discuss the latest drug discoveries that offer a glimmer of hope.
Discover the published article
NAR Cancer. 2022 Oct 28;4(4):zcac031.doi: 10.1093/narcan/zcac031. eCollection 2022 Dec.
Translational alterations in pancreatic cancer: a central role for the integrated stress response
Sauyeun Shin, Jacobo Solorzano, Mehdi Liauzun, Stéphane Pyronnet, Corinne Bousquet, Yvan Martineau
Collaborations and acknowledgements
This work was supported by LNCC (Labellisation Ligue Nationale Contre le Cancer) and the French National Institute of Cancer [INCA_16076 to Y.M., 2018–080 and 2018–082 to C.B.]. S.S. and M.L. were recipients of a fellowship from the LNCC and J.S. from Fondation Toulouse Cancer Sante/Region Occitanie. J.S. has been partially supported through the grant EUR CARe [ANR-18-EURE-0003] in the framework of the Programme des Investissements d’Avenir.
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