The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and the development of pancreatic cancer.

18 Jul 2024 | Discover home page, Discover ImPact

The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and the development of pancreatic cancer. thyroid hormone receptor interacting protein 12; pancreatic cancer; preneoplastic lesions; acinar-to-ductal metaplasia; E3 ubiquitin ligase...

An oncolytic virus with strong appetence for the most aggressive type of pancreatic cancer cells

11 Apr 2024 | Discover home page, Discover ImPact

An oncolytic virus with strong appetence for the most aggressive type of pancreatic cancer cells Oncolytic virus, pancreatic cancer, precision medicine Pierre Cordelier – Team ImPact – Therapeutic innovation in pancreatic cancer The Minute virus of mice...

Cytidine deaminase confers resistance to DNA-damaging drugs

2 Feb 2024 | Discover home page, Discover ImPact

Cytidine deaminase confers resistance to DNA-damaging drugs Pancreatic cancer, cytidine deaminase, replication stress, resistance to treatment Pierre Cordelier – Team ImPact – Therapeutic innovation in pancreatic cancer Cytidine deaminase (CDA) plays a...

Focus research 2022 ImPact team

2 Oct 2023 | Discover ImPact

Focus research 2022 ImPact team Pancreatic tumors are notorious for their resistance to immunotherapies. In this context, the ImPACT team has been investigating the therapeutic potential of Toll-like receptor (TLR) agonist molecules, which are expressed in tumors, and...

Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer

27 Mar 2023 | Discover home page, Discover ImPact

Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer Pancreatic cancer, non-viral gene therapy, resistance to treatment, chemotherapy, preclinical regulatory experiments. Pierre Cordelier Team ImPact- Therapeutic innovation in...

Pancreatic cancer cell and gene biotherapies; past, present and future

3 Jan 2023 | Discover home page, Discover ImPact

Pancreatic cancer cell and gene biotherapies; past, present and future Pancreatic cancer Biotherapy gene therapy Lorraine Quillien Team Impact – Therapeutic innovation in pancreatic cancer – Team Leader Pierre Cordelier Solid cancers remain a major health...