La Ligue Nationale Contre le Cancer accreditation / IGAALD team during 5 years

Oncogenic mechanisms in acute leukemia: Toward targeted therapy leukemia initiating cells

The development of acute leukemia in patients is a multistep process characterized by the acquisition of cumulative genetic alterations. Our research focuses in particular on the two oncogenic transcription factors PAX5 and GATA2, respectively involved in B-acute lymphoblastic leukemia (B-ALL) and in inherited myelodysplastic syndromes/acute myeloid leukemia (MDS/AML). Our team takes advantage of the discovery of PAX5 and GATA2 mutants (primary hits) and of coopera􀆟ng muta􀆟ons (secondary hits) in leukemia pa􀆟ents to modelize the disease through the genera􀆟on of cellular and transgenic mouse models. Combined with clinical studies and genetic profiling of leukemia patients, the development of those models aims to define and target the biological mechanisms by which PAX5 and GATA2 mutants induce leukemia initiation and lead to malignant transformation.

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches contre le Cancer de Toulouse (Oncopole)

Toulouse - FR

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