Focus research 2022 METAML team

In 2022, Dr. Jean-Emmanuel Sarry was awarded the Grand Prix Guy Lazorthes. All organisms adapt their metabolism in response to different types of stress in order to survive. This ability to respond metabolically to stress ensures heterogeneity and plasticity, leading to the emergence of cellular subpopulations with advantages in survival, proliferation and reconstitution of the original population. Jean-Emmanuel Sarry and his team have shown that this adaptive mechanism is a determinant of the therapy-resistant cancer cells responsible for relapse in many tumors. A better understanding of these metabolic adaptations should lead to new therapeutic solutions to overcome resistance. To find out more

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