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Rapid and sensitive detection of biomarkers of interest in cancerology

Rapid and sensitive detection of biomarkers of interest in cancerology

by Stephane Cailmail | 16 Feb 2021 | General news, Publications, Research

MicroRNAs are short non-coding RNA sequences whose expression is deregulated in cancers. In particular, miR-21 microRNA is a promising biomarker for the diagnosis and the monitoring of patients with pancreatic cancer. In this work, we use the µLAS microfluidic...
A novel imaging approach for single-cell, real-time analysis of oncolytic virus replication and efficacy in cancer cells

A novel imaging approach for single-cell, real-time analysis of oncolytic virus replication and efficacy in cancer cells

by Stephane Cailmail | 12 Feb 2021 | General news, Publications, Research

Oncolytic viruses infect and replicate in cancer cells to induce cell death. As such, they are promising new therapies against cancer. This study describes for the first time the antitumor activity of SG33, a veterinary vaccine strain derived from the Myxoma virus....
Normalization of protein secretion in tumour microenvironment inhibits metastasis development in pancreatic cancer

Normalization of protein secretion in tumour microenvironment inhibits metastasis development in pancreatic cancer

by Stephane Cailmail | 8 Feb 2021 | General news, Publications, Research

Fibroblasts present in pancreatic tumours produce large amounts of proteins, which promote the proliferation of cancer cells, as well as their ability to metastasize. We have shown that these fibroblasts can be targeted using a somatostatin analogue SOM230, a molecule...
Protocol to select antibodies that deplete their antigen inside the cells.

Protocol to select antibodies that deplete their antigen inside the cells.

by Stephane Cailmail | 5 Feb 2021 | General news, Publications, Research

It is important to be able to identify and validate new therapeutic strategies for proteins that are not currently targeted by inhibitors in cancers. Therapeutic antibodies are molecules of choice for the standard treatment of many forms of cancer. Their application...
Identification of therapeutic targets and drug repurposing against Covid19 based on proteins, diseases, drugs, and symptoms network analysis

Identification of therapeutic targets and drug repurposing against Covid19 based on proteins, diseases, drugs, and symptoms network analysis

by Stephane Cailmail | 26 Jan 2021 | Publications, Research

Network medicine aims at using networks to uncover patterns in diseases and use them to understand their biology and propose new drugs. Since the appearance of Covid19, the disease provoked by the SARS-Cov-2 virus, the research community all around the globe has been...
Genetic polymorphisms involved in trabectedin-related liver toxicity.

Genetic polymorphisms involved in trabectedin-related liver toxicity.

by Stephane Cailmail | 4 Jan 2021 | General news, Publications, Research

Trabectedin is a cytotoxic drug used for the treatment of advanced soft tissue sarcoma. One of the most frequent side effects is hepatotoxicity, which occurs in nearly 40% of patients. In this pharmacogenetic study, we aimed to identify genetic polymorphisms that...
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  • Rapid and sensitive detection of biomarkers of interest in cancerology
  • A novel imaging approach for single-cell, real-time analysis of oncolytic virus replication and efficacy in cancer cells
  • Normalization of protein secretion in tumour microenvironment inhibits metastasis development in pancreatic cancer
  • Protocol to select antibodies that deplete their antigen inside the cells.
  • Identification of therapeutic targets and drug repurposing against Covid19 based on proteins, diseases, drugs, and symptoms network analysis
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