by Stephane Cailmail | 7 Apr 2021 | General news, Publications, Research
Immunotherapy for advanced melanoma has revolutionized the treatment of this deadly cancer. However, almost half of patients do not respond to this treatment and die within 5 years after starting treatment. Our work shows that melanoma cells exhibit alterations in the...
by Stephane Cailmail | 1 Apr 2021 | Actualités générales, Publications, Research
Researchers from LAAS-CNRS, in collaboration with the Toulouse Cancer Research Centre, have shown how μLAS microfluidic chip technology can concentrate and measure microRNAs, cancer biomarkers, in less than a minute. MicroRNAs (miRs) are short fragments of RNA that...
by Stephane Cailmail | 23 Mar 2021 | Actualités générales, Publications, Research
PI3Ks are important molecules, that, by adding a tag on a lipid, induce messages (also called signals) in the cells. They are hence key regulators of cell signalling. In the animals of higher order, such as Humans, PI3Ks come in different flavours. In particular, the...
by Stephane Cailmail | 11 Mar 2021 | General news, Publications, Research
Melanoma is a bad-prognosis skin cancer generally treated with monoclonal antibodies that neutralize immune checkpoints such as anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab). Unfortunately, a significant proportion of patients do not respond to these treatments....
by Stephane Cailmail | 8 Mar 2021 | General news, Publications, Research
Fluoropyrimidines (including 5-fluorouracil and its prodrug capecitabine) can cause serious adverse events related to a dihydropyrimidine dehydrogenase (DPD) deficiency, the enzyme involved in the degradation of 5-FU. This study reports the case of a patient treated...
by Stephane Cailmail | 16 Feb 2021 | General news, Publications, Research
MicroRNAs are short non-coding RNA sequences whose expression is deregulated in cancers. In particular, miR-21 microRNA is a promising biomarker for the diagnosis and the monitoring of patients with pancreatic cancer. In this work, we use the µLAS microfluidic...
