2021
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Thibault, B; Ramos-Delgado F.and Pons-Tostivint, E.and Therville N; Cintas, C; Arcucci, S; Cassant-Sourdy, S; Reyes-Castellanos, G; Tosolini M.and Villard, AV. ; Cayron, C; Baer, R; Bertrand-Michel, J; Pagan, D; Da-Mota, DF. ; Yan, H; Falcomatà, C; Muscari, F; Bournet, B; Delord, JP. ; Aksoy, E; Carrier, A; Cordelier, P; Saur, D; Basset, C; Guillermet-Guibert, J Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component Article de journal EMBO Mol Med, p. e13502, 2021. Résumé | Liens | BibTeX @article{Thibault2021,
title = {Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component },
author = {Thibault, B . and Ramos-Delgado, F.and Pons-Tostivint, E.and Therville, N. and Cintas, C. and Arcucci, S. and Cassant-Sourdy, S. and Reyes-Castellanos, G. and Tosolini, M.and Villard, AV. and Cayron, C. and Baer, R. and Bertrand-Michel, J. and Pagan, D. and Da-Mota, DF. and Yan, H. and Falcomatà, C. and Muscari, F. and Bournet, B. and Delord, JP. and Aksoy, E. and Carrier, A. and Cordelier, P. and Saur, D. and Basset, C. and Guillermet-Guibert, J.},
url = {https://www.embopress.org/doi/full/10.15252/emmm.202013502},
doi = {10.15252/emmm.202013502},
year = {2021},
date = {2021-05-25},
journal = {EMBO Mol Med},
pages = {e13502},
abstract = {Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify key signalling events that drive metastatic evolution from the pancreas. We searched for a gene signature that discriminate localised PDAC from confirmed metastatic PDAC and devised a preclinical protocol using circulating cell-free DNA (cfDNA) as an early biomarker of micro-metastatic disease to validate the identification of key signalling events. An unbiased approach identified, amongst actionable markers of disease progression, the PI3K pathway and a distinctive PI3Kα activation signature as predictive of PDAC aggressiveness and prognosis. Pharmacological or tumour-restricted genetic PI3Kα-selective inhibition prevented macro-metastatic evolution by hindering tumoural cell migratory behaviour independently of genetic alterations. We found that PI3Kα inhibition altered the quantity and the species composition of the produced lipid second messenger PIP3 , with a selective decrease of C36:2 PI-3,4,5-P3 . Tumoural PI3Kα inactivation prevented the accumulation of pro-tumoural CD206-positive macrophages in the tumour-adjacent tissue. Tumour cell-intrinsic PI3Kα promotes pro-metastatic features that could be pharmacologically targeted to delay macro-metastatic evolution. },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify key signalling events that drive metastatic evolution from the pancreas. We searched for a gene signature that discriminate localised PDAC from confirmed metastatic PDAC and devised a preclinical protocol using circulating cell-free DNA (cfDNA) as an early biomarker of micro-metastatic disease to validate the identification of key signalling events. An unbiased approach identified, amongst actionable markers of disease progression, the PI3K pathway and a distinctive PI3Kα activation signature as predictive of PDAC aggressiveness and prognosis. Pharmacological or tumour-restricted genetic PI3Kα-selective inhibition prevented macro-metastatic evolution by hindering tumoural cell migratory behaviour independently of genetic alterations. We found that PI3Kα inhibition altered the quantity and the species composition of the produced lipid second messenger PIP3 , with a selective decrease of C36:2 PI-3,4,5-P3 . Tumoural PI3Kα inactivation prevented the accumulation of pro-tumoural CD206-positive macrophages in the tumour-adjacent tissue. Tumour cell-intrinsic PI3Kα promotes pro-metastatic features that could be pharmacologically targeted to delay macro-metastatic evolution. |
2017
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Chuvin, N; Vincent, D F; Pommier, R M; Alcaraz, L B; Gout, J; Caligaris, C; Yacoub, K; Cardot, V; Roger, E; Kaniewski, B; Martel, S; Cintas, C; Goddard-Leon, S; Colombe, A; Valantin, J; Gadot, N; Servoz, E; Morton, J; Goddard, I; Couvelard, A; Rebours, V; Guillermet, J; Sansom, O J; Treilleux, I; Valcourt, U; Sentis, S; Dubus, P; Bartholin, L Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis Article de journal Cell Mol Gastroenterol Hepatol, 4 (2), p. 263-282, 2017, ISSN: 2352-345X (Print) 2352-345X (Linking). Liens | BibTeX @article{RN1b,
title = {Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis},
author = {Chuvin, N. and Vincent, D. F. and Pommier, R. M. and Alcaraz, L. B. and Gout, J. and Caligaris, C. and Yacoub, K. and Cardot, V. and Roger, E. and Kaniewski, B. and Martel, S. and Cintas, C. and Goddard-Leon, S. and Colombe, A. and Valantin, J. and Gadot, N. and Servoz, E. and Morton, J. and Goddard, I. and Couvelard, A. and Rebours, V. and Guillermet, J. and Sansom, O. J. and Treilleux, I. and Valcourt, U. and Sentis, S. and Dubus, P. and Bartholin, L.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/28752115},
doi = {10.1016/j.jcmgh.2017.05.005},
issn = {2352-345X (Print) 2352-345X (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Cell Mol Gastroenterol Hepatol},
volume = {4},
number = {2},
pages = {263-282},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Pons-Tostivint, E; Thibault, B; Guillermet-Guibert, J Targeting PI3K Signaling in Combination Cancer Therapy Article de journal Trends Cancer, 3 (6), p. 454-469, 2017, ISSN: 2405-8025 (Electronic)
2405-8025 (Linking). Liens | BibTeX @article{RN2b,
title = {Targeting PI3K Signaling in Combination Cancer Therapy},
author = {Pons-Tostivint, E. and Thibault, B. and Guillermet-Guibert, J.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/28718419},
doi = {10.1016/j.trecan.2017.04.002},
issn = {2405-8025 (Electronic)
2405-8025 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Trends Cancer},
volume = {3},
number = {6},
pages = {454-469},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2016
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Morfoisse, F; Tatin, F; Hantelys, F; Adoue, A; Helfer, A C; Cassant-Sourdy, S; Pujol, F; Gomez-Brouchet, A; Ligat, L; Lopez, F; Pyronnet, S; Courty, J; Guillermet-Guibert, J; Marzi, S; Schneider, R J; Prats, A C; Garmy-Susini, B H Nucleolin Promotes Heat Shock-Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis Article de journal Cancer Res, 76 (15), p. 4394-405, 2016, ISSN: 1538-7445 (Electronic)
0008-5472 (Linking). Liens | BibTeX @article{RN3b,
title = {Nucleolin Promotes Heat Shock-Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis},
author = {Morfoisse, F. and Tatin, F. and Hantelys, F. and Adoue, A. and Helfer, A. C. and Cassant-Sourdy, S. and Pujol, F. and Gomez-Brouchet, A. and Ligat, L. and Lopez, F. and Pyronnet, S. and Courty, J. and Guillermet-Guibert, J. and Marzi, S. and Schneider, R. J. and Prats, A. C. and Garmy-Susini, B. H.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27280395},
doi = {10.1158/0008-5472.CAN-15-3140},
issn = {1538-7445 (Electronic)
0008-5472 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Cancer Res},
volume = {76},
number = {15},
pages = {4394-405},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2015
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Baer, R; Cintas, C; Therville, N; Guillermet-Guibert, J Implication of PI3K/Akt pathway in pancreatic cancer: When PI3K isoforms matter? Article de journal Adv Biol Regul, 59 , p. 19-35, 2015, ISSN: 2212-4934 (Electronic)
2212-4926 (Linking). Liens | BibTeX @article{RN6b,
title = {Implication of PI3K/Akt pathway in pancreatic cancer: When PI3K isoforms matter?},
author = {Baer, R. and Cintas, C. and Therville, N. and Guillermet-Guibert, J.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26166735},
doi = {10.1016/j.jbior.2015.05.001},
issn = {2212-4934 (Electronic)
2212-4926 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Adv Biol Regul},
volume = {59},
pages = {19-35},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Guillermet-Guibert, J; Smith, L B; Halet, G; Whitehead, M A; Pearce, W; Rebourcet, D; Leon, K; Crepieux, P; Nock, G; Stromstedt, M; Enerback, M; Chelala, C; Graupera, M; Carroll, J; Cosulich, S; Saunders, P T; Huhtaniemi, I; Vanhaesebroeck, B Novel Role for p110beta PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells Article de journal PLoS Genet, 11 (7), p. e1005304, 2015, ISSN: 1553-7404 (Electronic)
1553-7390 (Linking). Liens | BibTeX @article{RN7b,
title = {Novel Role for p110beta PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells},
author = {Guillermet-Guibert, J. and Smith, L. B. and Halet, G. and Whitehead, M. A. and Pearce, W. and Rebourcet, D. and Leon, K. and Crepieux, P. and Nock, G. and Stromstedt, M. and Enerback, M. and Chelala, C. and Graupera, M. and Carroll, J. and Cosulich, S. and Saunders, P. T. and Huhtaniemi, I. and Vanhaesebroeck, B.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26132308},
doi = {10.1371/journal.pgen.1005304},
issn = {1553-7404 (Electronic)
1553-7390 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {PLoS Genet},
volume = {11},
number = {7},
pages = {e1005304},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Jeannot, P; Callot, C; Baer, R; Duquesnes, N; Guerra, C; Guillermet-Guibert, J; Bachs, O; Besson, A Loss of p27Kip(1) promotes metaplasia in the pancreas via the regulation of Sox9 expression Article de journal Oncotarget, 6 (34), p. 35880-92, 2015, ISSN: 1949-2553 (Electronic)
1949-2553 (Linking). Liens | BibTeX @article{RN5b,
title = {Loss of p27Kip(1) promotes metaplasia in the pancreas via the regulation of Sox9 expression},
author = {Jeannot, P. and Callot, C. and Baer, R. and Duquesnes, N. and Guerra, C. and Guillermet-Guibert, J. and Bachs, O. and Besson, A.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26416424},
doi = {10.18632/oncotarget.5770},
issn = {1949-2553 (Electronic)
1949-2553 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Oncotarget},
volume = {6},
number = {34},
pages = {35880-92},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Ligat, L; Saint-Laurent, N; El-Mrani, A; Gigoux, V; Al Saati, T; Tomasini, R; Nigri, J; Dejean, S; Pont, F; Baer, R; Guillermet-Guibert, J; Cordelier, P; Lopez, F; Dufresne, M Pancreatic preneoplastic lesions plasma signatures and biomarkers based on proteome profiling of mouse models Article de journal Br J Cancer, 113 (11), p. 1590-8, 2015, ISSN: 1532-1827 (Electronic)
0007-0920 (Linking). Liens | BibTeX @article{RN4b,
title = {Pancreatic preneoplastic lesions plasma signatures and biomarkers based on proteome profiling of mouse models},
author = {Ligat, L. and Saint-Laurent, N. and El-Mrani, A. and Gigoux, V. and Al Saati, T. and Tomasini, R. and Nigri, J. and Dejean, S. and Pont, F. and Baer, R. and Guillermet-Guibert, J. and Cordelier, P. and Lopez, F. and Dufresne, M.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26512875},
doi = {10.1038/bjc.2015.370},
issn = {1532-1827 (Electronic)
0007-0920 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Br J Cancer},
volume = {113},
number = {11},
pages = {1590-8},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2014
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Baer, R; Cintas, C; Dufresne, M; Cassant-Sourdy, S; Schonhuber, N; Planque, L; Lulka, H; Couderc, B; Bousquet, C; Garmy-Susini, B; Vanhaesebroeck, B; Pyronnet, S; Saur, D; Guillermet-Guibert, J Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110alpha Article de journal Genes Dev, 28 (23), p. 2621-35, 2014, ISSN: 1549-5477 (Electronic)
0890-9369 (Linking). Liens | BibTeX @article{RN8b,
title = {Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110alpha},
author = {Baer, R. and Cintas, C. and Dufresne, M. and Cassant-Sourdy, S. and Schonhuber, N. and Planque, L. and Lulka, H. and Couderc, B. and Bousquet, C. and Garmy-Susini, B. and Vanhaesebroeck, B. and Pyronnet, S. and Saur, D. and Guillermet-Guibert, J.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/25452273},
doi = {10.1101/gad.249409.114},
issn = {1549-5477 (Electronic)
0890-9369 (Linking)},
year = {2014},
date = {2014-01-01},
journal = {Genes Dev},
volume = {28},
number = {23},
pages = {2621-35},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Morfoisse, F; Kuchnio, A; Frainay, C; Gomez-Brouchet, A; Delisle, M B; Marzi, S; Helfer, A C; Hantelys, F; Pujol, F; Guillermet-Guibert, J; Bousquet, C; Dewerchin, M; Pyronnet, S; Prats, A C; Carmeliet, P; Garmy-Susini, B Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1alpha-independent translation-mediated mechanism Article de journal Cell Rep, 6 (1), p. 155-67, 2014, ISSN: 2211-1247 (Electronic). Liens | BibTeX @article{RN9b,
title = {Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1alpha-independent translation-mediated mechanism},
author = {Morfoisse, F. and Kuchnio, A. and Frainay, C. and Gomez-Brouchet, A. and Delisle, M. B. and Marzi, S. and Helfer, A. C. and Hantelys, F. and Pujol, F. and Guillermet-Guibert, J. and Bousquet, C. and Dewerchin, M. and Pyronnet, S. and Prats, A. C. and Carmeliet, P. and Garmy-Susini, B.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/24388748},
doi = {10.1016/j.celrep.2013.12.011},
issn = {2211-1247 (Electronic)},
year = {2014},
date = {2014-01-01},
journal = {Cell Rep},
volume = {6},
number = {1},
pages = {155-67},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2010
|
Vanhaesebroeck, B; Guillermet-Guibert, J; Graupera, M; Bilanges, B The emerging mechanisms of isoform-specific PI3K signalling Article de journal Nat Rev Mol Cell Biol, 11 (5), p. 329-41, 2010, ISSN: 1471-0080 (Electronic)
1471-0072 (Linking). Liens | BibTeX @article{RN10,
title = {The emerging mechanisms of isoform-specific PI3K signalling},
author = {Vanhaesebroeck, B. and Guillermet-Guibert, J. and Graupera, M. and Bilanges, B.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/20379207},
doi = {10.1038/nrm2882},
issn = {1471-0080 (Electronic)
1471-0072 (Linking)},
year = {2010},
date = {2010-01-01},
journal = {Nat Rev Mol Cell Biol},
volume = {11},
number = {5},
pages = {329-41},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
