A tumour cell experiences mechanical forces of compression, traction and shear. These physical forces induce a signal in the cancer cell. The transmission of this signal is very fast and involves deformation of the cell. A huge current research effort is aimed at understanding how tumour cell deformations are translated into intracellular signals that promote tumour progression. A new avenue of research that we highlight in this article is the activation of the PI3K pathway.

The PI3K pathway is a target for new anti-cancer therapies. In this review article, the SigDYN team attempts to understand how these targeted therapies respond when tumour cells are subjected to mechanical forces and thus better predict their efficacy in patients.

Discover the published article :

Trends Biochem Sci. 2021 Jun 7;S0968-0004(21)00108-0.doi: 10.1016/j.tibs.2021.05.005. Online ahead of print.
PI3K functions as a hub in mechanotransduction
M Di-Luoffo , Z Ben-Meriem , P Lefebvre , M Delarue , J Guillermet-Guibert

Key words :

• PI3K,
• cell signalling,
• cancer,
• mechanical stress,
• mechanotransduction

Collaborations and acknowledgements

This work was carried out in collaboration with the Laboratory of Analysis and Architecture of Systems – LAAS – which is a research unit of the National Centre for Scientific Research located at the Lespinet space complex in Toulouse. It benefits from the financial support of the Toulouse Cancer Health Foundation and the Cancer Plan.

Contact :

Julie Guillermet-Guibert et Mickaël Di-Luoffo
CRCT team : SigDYN : Integrated cell signalling and class I-II-III isoforms of PI3K
Mail : mickael.di-luoffo@inserm.fr

One Picture

Finding the Achilles heel to target in pressurised cells: the importance of PI3K. Editing: Mickaël Di-Luoffo, adapted from erhui1979 – Getty