Genomic analysis of acute leukemia
Eric Delabesse, PharmD, PhD, PU-PH CHU Toulouse
The development of acute leukemia results from the acquisition of a limited number of mutations, 1 to 5, rarely more, making it one of the least mutated cancers. Consequently, the leukemic process can be studied by reconstructing these steps, as in our publication in Proc Natl Acad Sci USA of 2018 (Jamrog L et al., PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice. Proc Natl Acad Sci U S A. 2018;115(41):10357-10362).
Because of my participation in the main national clinical networks for acute leukemia, I analyze with the most advanced genomic techniques the order of appearance and the association of mutations during leukemic development in order to reproduce them in controlled models of leukemogenesis (cellular or murine models).