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A journey within the tumor microenvironment reveals STAT3 as a central hub for fibroblast activation in epidermoid carcinomas. A key determinant for sSCC metastatic progression relies in the intricate interplay between cancer cells and tumor microenvironment. Carcinoma-associated fibroblasts (CAF) profoundly impact cancer aggressiveness by orchestrating the tumor ecosystem. Two major sub-populations of CAF, the myofibroblastic […]