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A digital twin of oxidative metabolism to better understand the mechanisms underlying neurodegenerative diseases and ageing. Mitochondria play an essential role in the production of the energy required for cell function by generating adenosine triphosphate (ATP) through redox reactions, which are catalyzed by the five complexes of the mitochondrial respiratory chain. These reactions require electron […]

Résumé : Insights into the molecular mechanisms underlying T-cell responses. T cells are central players in the immune response, interpreting signals from their environment through the T cell receptor (TCR) to trigger specific cellular actions. Our team seeks to decode the molecular and cellular processes that guide T cell behavior under different physiological conditions. Through […]

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Explorer la structure des données complexes : du clustering spectral à l’analyse multimodale Cette présentation portera sur une approche spectrale de clustering entièrement automatisée, reposant notamment sur un équilibrage doublement stochastique et l’optimisation de la modularité pour la détection automatique de structures dans les données. Dans un second temps, seront présentés les premiers résultats de […]

Biosketch/Roles Professor of Cell Biology, Medicine, and Oncology Director of Scientific Resources of the Stem Cell Institute Seminar Abstract The Ito lab aims to illuminate the pathways that govern stem cell self-renewal and differentiation. They have developed single‑cell approaches that reveal mitophagy driven by fatty acid (FA) metabolism as a key driver of hematopoietic stem […]

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Hematopoietic Decline during Inflammaging: Models expose multiple mechanisms Alexander Hoffmann Department of Microbiology, Immunology, and Molecular Genetics Institute for Quantitative and Computational Biosciences UCLA, Los Angeles, CA 90066 The effectiveness of the immune system declines with age and associated chronic inflammation, termed “Inflammaging”. Most marked is the reduction in B-cell populations, and their hematopoietic progenitors […]