Workshop Hematology & Immunology
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Multiscale Modeling of Biological Systems: Integrating Metabolism, ECM Dynamics, and AI-Driven Workflows within the PhysiCell Framework Multiscale models provide a powerful means of studying complex biological processes across multiple spatial and temporal scales. They capture both intracellular events, such as signaling and metabolism, and extracellular interactions where cells communicate and coordinate. By revealing how genetic […]
Conférence | From the clinic to the bench, and back to the clinic: applications of clinical pharmacogenetics in breast cancer, Maud Maillard - équipe DIAD
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L'Ia telle que vous l'avez découverte à compter de Novembre 2022, générative et universelle, repose sur un matériau essentiel : “la (big) data” ;-)! Or, ces données, loin d’être neutres, sont les miroirs des biais, inégalités et limites des systèmes de santé qui les produisent: sous-représentation de certaines populations dans les bases de données, différences […]
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A journey within the tumor microenvironment reveals STAT3 as a central hub for fibroblast activation in epidermoid carcinomas. A key determinant for sSCC metastatic progression relies in the intricate interplay between cancer cells and tumor microenvironment. Carcinoma-associated fibroblasts (CAF) profoundly impact cancer aggressiveness by orchestrating the tumor ecosystem. Two major sub-populations of CAF, the myofibroblastic […]
A digital twin of oxidative metabolism to better understand the mechanisms underlying neurodegenerative diseases and ageing. Mitochondria play an essential role in the production of the energy required for cell function by generating adenosine triphosphate (ATP) through redox reactions, which are catalyzed by the five complexes of the mitochondrial respiratory chain. These reactions require electron […]
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Résumé : Insights into the molecular mechanisms underlying T-cell responses. T cells are central players in the immune response, interpreting signals from their environment through the T cell receptor (TCR) to trigger specific cellular actions. Our team seeks to decode the molecular and cellular processes that guide T cell behavior under different physiological conditions. Through […]