Dr Jean-Emmanuel Sarry is the winner of the 2022 Guy Lazorthes Prize.

All organisms adapt their metabolism in response to various types of stress in order to survive. This ability to mount a metabolic response to stress ensures heterogeneity and plasticity, leading to the emergence of cellular subpopulations with advantages in survival, proliferation, and reconstitution of the original population. Jean-Emmanuel Sarry and his team at the Cancer Research Center of Toulouse have shown that this adaptive mechanism is a key determinant of therapy-resistant cancer cells responsible for relapse in many tumors. A better understanding of these metabolic adaptations therefore opens the way to new therapeutic strategies to overcome resistance.
The Academy paid tribute to him on the occasion of the formal presentation of his award under the Dome of the Institut de France on October 18, 2022.