Postdoctoral Position in Oncoimmunology – Super Killer CAR T cells
A postdoctoral position, with salary funded by prestigious European Research Council Synergy Grant is available immediately for a year in the team 20 “Molecular dynamics of lymphocytes interactions” of the Cancer Research Centre of Toulouse (DynACT, CRCT) directed by Dr. Valitutti. The project is based on dynamic international collaborations with the Universities of Oxford (UK), Siena (Italy) and Saarland (Germany).
The successful candidate will investigate functional signatures of CD8+ cytotoxic T cells, focusing on distinguishing between highly efficient and poor killer T cell phenotypes. The project will begin with in vitro analyses of cytotoxic activity using various multiplexed assays (scRNA-seq, flow cytometry) and imaging techniques. This phase will be followed by translational studies aiming to assess these signatures in clinical samples from melanoma patients, using spatial proteomics (Phenocycler Fusion, Akoya). In a later stage of the project, the findings will be explored in the context of CAR-T cell therapy in patients with diffuse large B-cell lymphoma (DLBL), in collaboration with the hematology department at IUCT-Oncopole. The objective will then be to correlate CAR-T cell signatures with clinical responses and to identify new molecular mechanisms or actionable markers to enhance their therapeutic efficacy.
Location: Cancer Research Center of Toulouse, France
Duration: 18 months, subjected to possible extension
Application Deadline: 01/07/2025