Bastien Gerby

Bastien Gerby
Nationalité / Nationality :
France
Équipe(s) / Team(s) :
N° tel / Phone number :
Email
bastien.gerby@inserm.fr
Numéro ORCID / ORCID ID :
0000-0002-2657-4200
Réseaux sociaux / Social networks :
Chercheur / Researcher
CNRS
Titre de la thèse / Thesis Tittle :
Identification des cellules initiant les LAL-T humaines dans les souris immunodéficientes et étude de la modulation de l'expression de l'oncogène SCL/TAL1 sur le développement leucémique
Année / year :
2010
Université / University :
Université Paris VII Denis-Diderot
Directeur de Thèse / Thesis director :
Pflumio Françoise

HDR :
2020
Missions :

Current chemotherapy of leukemia aims to eliminate the bulk of the cancer but spares leukemia-initiating cells (LICs) that cause relapse of the disease. In addition, these treatments induce a number of side effects and are also limited by toxicity towards normal hematopoietic stem cells (HSCs). This points the need to identify new drugs targeting LICs.
My research focuses on the phenotypic, molecular and functional characterization of LICs to develop therapies that specifically target their markers and/or biological mechanisms in order to eradicate cancer and prevent relapse. Precisely, my research aims to understand the mechanisms involved in the early stages of leukemia development. I am interested in how human oncogenes convert hematopoietic progenitors into LICs and how to develop powerful chemical screening strategies to find new promising leukemia treatment targeting specifically LICs without affecting normal HSC functions.

Expertises et mandats / Expertises and mandates :

My research interests lie in the field of hematology and stem cells and my areas of expertise are acute lymphoblastic leukemia, leukemia-initiating cells, oncogene-induced reprogramming, genetic mouse models and drug screening.

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