Équipe
Jean-EMMANUEL SARRY – Fabienne BRENET
METAML :
Métabolisme et résistance thérapeutique
dans les leucémies aiguës myéloïdes
Le laboratoire d’Excellence Toulouse Cancer est un projet qui vise à comprendre les mécanismes de résistance et de rechute dans les cancers.
Equipe Labellisée Ligue contre le cancer
Les spécificités
de notre axe de recherche
« Ce ne sont pas les espèces les plus fortes, ni la plus intelligentes qui survivent,
mais celles qui sont le plus (métaboliquement et mitochondrialement) adaptable au changement.
Malgré des taux élevés de rémission après traitement, la résistance inévitable aux thérapies conduit finalement à des rechutes fréquentes et à la mort chez de nombreux patients atteints de cancer. Le principal défi dans l’éradication des cellules initiatrices de rechute (RICs) réside dans la surveillance de ces cellules résiduelles et dans l’élucidation de leurs mécanismes de résistance in vivo.
Il y a près de quinze ans, nous avons entrepris de caractériser de nouveaux mécanismes de résistance aux traitements dans la leucémie myéloïde aiguë (LMA), l’un des modèles de cancer les plus pertinents pour l’étude de la résistance thérapeutique. Nos résultats ont mis en évidence les différences entre le modèle d’hétérogénéité leucémique et le modèle hiérarchique des cellules souches, apportant des preuves claires de mécanismes de résistance non génétiques (métaboliques). Nos travaux ont démontré, pour la première fois, que la résistance thérapeutique dans la LMA est portée par une capacité accrue des RICs à réaliser une adaptation mitochondriale et une flexibilité métabolique.
Cependant, bien que les caractéristiques métaboliques des cellules persistantes tolérantes aux médicaments (DTPs) soient mieux connues, les déterminants non génétiques opérant aux niveaux tissulaire et systémique, qui favorisent la résistance et la rechute, demeurent encore mal compris.
Dans ce contexte, nous testons l’hypothèse selon laquelle la capacité éco-évolutive (métabolique/épigénétique) et l’adaptation mitochondriale des populations cellulaires microenvironnementales (TME) et tumorales constituent des déterminants majeurs de la compétition darwinienne qui sélectionne les populations cellulaires persistantes conduisant à la rechute.
Nous cherchons désormais à comprendre en profondeur pourquoi les thérapies échouent, en disséquant les processus évolutifs, métaboliques et écologiques qui sélectionnent et préparent les populations de DTPs aux niveaux tissulaire et systémique, tout au long du continuum du cancer dans le temps et l’espace, grâce à l’intégration d’approches multi-omiques unicellulaires et spatiales.
Une meilleure compréhension de ces mécanismes interconnectés fournira des pistes translationnelles inédites vers l’identification de biomarqueurs mitochondriaux, permettant une meilleure stratification des patients et ouvrant la voie à des stratégies thérapeutiques métaboliques innovantes, basées sur des combinaisons personnalisées ciblant les dépendances de l’hôte.
Leucémies Myéloïdes Aiguës,
Métabolisme hôte/tumeur,
Stress mitochondrial/adaptations,
Maladie résiduelle et hétérogénéité des DTPs,
Communité de cellules et comportement collectif,
Eco-Evo TME/trajectoires tumorale dans le temps et l’espace,
Résistance thérapeutique,
Thérapie métabolique adaptative,
Vieillissement,
DES PROJETS
DE RECHERCHE
Jean-Emmanuel Sarry
Fabienne Brenet
Déchiffrer les dynamiques spatio-temporelles de l’hétérogénéité métabolique au sein des compartiments leucémiques et micro-environnementaux contribuant à la résistance aux traitements in vivo.
Développement clinique et applications
Explorer l’impact du métabolisme systémique de l’hôte sur la persistance aux traitements in vivo.
Étudier l’impact des facteurs extrinsèques de l’hôte sur la persistance aux traitements in vivo.
LES FOCUS
DE L’ÉQUIPE
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PRODUCTIONS SCIENTIFIQUES
PUBLICATIONS 2025
7813506
8HPIVX5A
2025
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Damaskou, Aristi, Rachael Wilson, Malgorzata Gozdecka, George Giotopoulos, Ryan Asby, Maria Eleftheriou, Muxin Gu, et al. “Posttranscriptional Depletion of Ribosome Biogenesis Factors Engenders Therapeutic Vulnerabilities in NPM1 -Mutant AML.” Blood 146, no. 10 (September 4, 2025): 1239–52. https://doi.org/10.1182/blood.2024026113.
Soumoy, Laura, Aline Genbauffe, Dorianne Sant’Angelo, Maude Everaert, Léa Mukeba-Harchies, Jean-Emmanuel Sarry, Anne-Emilie Declèves, and Fabrice Journe. “Therapeutic Potential of Glutaminase Inhibition Targeting Metabolic Adaptations in Resistant Melanomas to Targeted Therapy.” International Journal of Molecular Sciences 26, no. 17 (August 25, 2025): 8241. https://doi.org/10.3390/ijms26178241.
Guyonnet, Sophie, Claudie Hooper, Heike A. Bischoff-Ferrari, Angelo Parini, Yohan Santin, Jean-Philippe Pradère, Cédric Dray, et al. “HealthAge: Evaluation of Intrinsic Capacity Changes in Humans, Mice, and Killifish to Explore the Biology of Aging.” GeroScience, June 16, 2025. https://doi.org/10.1007/s11357-025-01718-2.
Turesson, Annelie, Afsaneh Koochek, Margaretha Nydahl, Jean-Marc Lemaitre, Paul Bensadoun, Laurent O. Martinez, Sophie Guyonnet, et al. “The Associations between Biological Markers of Aging and Appetite Loss across Adulthood: Retrospective Case–Control Data from the INSPIRE-T Study.” GeroScience, May 10, 2025. https://doi.org/10.1007/s11357-025-01691-w.
Mourou, K., Y. Abou Monsef, S. Belluco, M. Penent, M. Delverdier, M. Hugonnard, F. Granat, R. Lavoue, and M. Mantelli. “Acute and Chronic Systemic Inflammation Associated with Canine Nodular Splenic Lesions Composed of Heterogeneous Cell Components: Four Cases (2020-2024).” The Journal of Small Animal Practice 66, no. 4 (April 2025): 280–90. https://doi.org/10.1111/jsap.13826.
Pottier, Aurélien, Sujung Park, Yejin Lee, Francesca Liccardo, Haeun Yang, Jeonghye Park, Anne Lorant, et al. “TP53-Agnostic Lethality through Combined Pan-HDAC and CDK Inhibition in Acute Myeloid Leukemia.” Cancer Letters 633 (2025): 218011. https://doi.org/10.1016/j.canlet.2025.218011.
Lu, Wan‐Hsuan, Sophie Guyonnet, Jérémy Raffin, Sandrine Bessou‐Touya, Katia Ravard Helffer, Pascale Bianchi, Jimmy Le Digabel, et al. “Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20–93: The INSPIRE ‐T Project.” Aging Cell 24, no. 10 (2025): e70190. https://doi.org/10.1111/acel.70190.
Skuli, Sarah J., A’ishah Bakayoko, Marisa Kruidenier, Bryan Manning, Paige Pammer, Akmal Salimov, Owen Riley, et al. “Chemoresistance of TP53 Mutant Acute Myeloid Leukemia Requires the Mevalonate Byproduct, Geranylgeranyl Pyrophosphate, for Induction of an Adaptive Stress Response.” Leukemia 39, no. 9 (2025): 2087–98. https://doi.org/10.1038/s41375-025-02668-6.
Gabellier, Ludovic, Enzo Bosetta, Maël Heiblig, and Jean-Emmanuel Sarry. “Metabolism and Therapeutic Response in Acute Myeloid Leukemia with IDH1/2 Mutations.” Trends in Cancer 11, no. 5 (2025): 475–90. https://doi.org/10.1016/j.trecan.2025.01.011.
Gabellier, Ludovic, Enzo Bosetta, Maël Heiblig, and Jean-Emmanuel Sarry. “Leucémies Aigües Myéloïdes Avec Mutations IDH1/2: Métabolisme et Réponse Thérapeutique.” Médecine/Sciences 41, no. 4 (2025): 355–66. https://doi.org/10.1051/medsci/2025045.
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Frances, Audrey, Audrey Lumeau, Nicolas Bery, Marion Gayral, Lucille Stuani, Marie Sorbara, Estelle Saland, et al. “Cytidine Deaminase-Dependent Mitochondrial Biogenesis as a Potential Vulnerability in Pancreatic Cancer Cells.” Communications Biology 7, no. 1 (August 30, 2024): 1065. https://doi.org/10.1038/s42003-024-06760-y.
Dembitz, Vilma, Hannah Lawson, Richard Burt, Sirisha Natani, Céline Philippe, Sophie C. James, Samantha Atkinson, et al. “Stearoyl-CoA Desaturase Inhibition Is Toxic to Acute Myeloid Leukemia Displaying High Levels of the de Novo Fatty Acid Biosynthesis and Desaturation.” Leukemia, August 26, 2024. https://doi.org/10.1038/s41375-024-02390-9.
Boët, Emeline, Estelle Saland, Sarah Skuli, Emmanuel Griessinger, and Jean-Emmanuel Sarry. “Mitohormesis : La Clé de Voûte de La Résistance Thérapeutique Des Cellules Cancéreuses.” Comptes Rendus. Biologies 347, no. G1 (August 22, 2024): 59–75. https://doi.org/10.5802/crbiol.154.
Larrue, Clement, Sarah Mouche, Paolo Angelino, Maxime Sajot, Rudy Birsen, Olivier Kosmider, Thomas Mckee, et al. “Targeting Ferritinophagy Impairs Quiescent Cancer Stem Cells in Acute Myeloid Leukemia in Vitro and in Vivo Models.” Science Translational Medicine 16, no. 757 (July 24, 2024): eadk1731. https://doi.org/10.1126/scitranslmed.adk1731.
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https://www.crct-inserm.fr/wp-content/plugins/zotpress/
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Mondesir, Johanna, Margherita Ghisi, Laura Poillet, Robert A. Bossong, Oliver Kepp, Guido Kroemer, Jean-Emmanuel Sarry, Jérôme Tamburini, and Andrew A. Lane. “AMPK Activation Induces Immunogenic Cell Death in AML.” Blood Advances 7, no. 24 (December 26, 2023): 7585–96. https://doi.org/10.1182/bloodadvances.2022009444.
Mouchel, Pierre Luc, Emilie Bérard, Suzanne Tavitian, Noémie Gadaud, Francois Vergez, Jean Baptiste Rieu, Isabelle Luquet, et al. “Vitamin C and D Supplementation in Acute Myeloid Leukemia.” Blood Advances, September 6, 2023, bloodadvances.2023010559. https://doi.org/10.1182/bloodadvances.2023010559.
Farge, Thomas, Jean Nakhle, Damien Lagarde, Guillaume Cognet, Nathaniel Polley, Rémy Castellano, Marie-Laure Nicolau, et al. “CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia.” Cancer Research 83, no. 17 (September 1, 2023): 2824–38. https://doi.org/10.1158/0008-5472.CAN-22-3682.
Courdy, Charly, Loïc Platteeuw, Charlotte Ducau, Isabelle De Araujo, Emeline Boet, Ambrine Sahal, Estelle Saland, et al. “Targeting PP2A-Dependent Autophagy Enhances Sensitivity to Ruxolitinib in JAK2V617F Myeloproliferative Neoplasms.” Blood Cancer Journal 13, no. 1 (July 10, 2023): 106. https://doi.org/10.1038/s41408-023-00875-x.
Griessinger, Emmanuel, Diego Pereira-Martins, Marielle Nebout, Claudie Bosc, Estelle Saland, Emeline Boet, Ambrine Sahal, et al. “Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold.” Cancer Research, June 5, 2023, CAN-23-1006. https://doi.org/10.1158/0008-5472.CAN-23-1006.
Sabatier, Marie, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Lea Goupille, et al. “C/EBPa Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia.” Cancer Discovery, April 3, 2023, CD-22-0411. https://doi.org/10.1158/2159-8290.CD-22-0411.
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https://www.crct-inserm.fr/wp-content/plugins/zotpress/
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Dumas, Pierre-Yves, Sarah Bertoli, Caroline Bonmati, Martin Carre, Juliette Lambert, Mario Ojeda-Uribe, Sylvain Chantepie, et al. “Characteristics and Clinical Outcomes of SARS-CoV-2 Infection in Adult Patients with Acute Leukemia in France.” Leukemia Research 120 (June 20, 2022): 106901. https://doi.org/10.1016/j.leukres.2022.106901.
Seiler, Kristina, Magali Humbert, Petra Minder, Iris Mashimo, Anna M. Schläfli, Deborah Krauer, Elena A. Federzoni, et al. “Hexokinase 3 Enhances Myeloid Cell Survival via Non-Glycolytic Functions.” Cell Death & Disease 13, no. 5 (May 11, 2022): 448. https://doi.org/10.1038/s41419-022-04891-w.
Decroocq, Justine, Rudy Birsen, Camille Montersino, Prasad Chaskar, Jordi Mano, Laury Poulain, Chloe Friedrich, et al. “RAS Activation Induces Synthetic Lethality of MEK Inhibition with Mitochondrial Oxidative Metabolism in Acute Myeloid Leukemia.” Leukemia 36, no. 5 (May 2022): 1237–52. https://doi.org/10.1038/s41375-022-01541-0.
Paolillo, Rosa, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, et al. “The NADPH Oxidase NOX2 Is a Marker of Adverse Prognosis Involved in Chemoresistance of Acute Myeloid Leukemias.” Haematologica, February 17, 2022. https://doi.org/10.3324/haematol.2021.279889.
Birsen, Rudy, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, et al. “APR-246 Induces Early Cell Death by Ferroptosis in Acute Myeloid Leukemia.” Haematologica 107, no. 2 (February 1, 2022): 403–16. https://doi.org/10.3324/haematol.2020.259531.
Grenier, Adrien, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, et al. “AMPK-PERK Axis Represses Oxidative Metabolism and Enhances Apoptotic Priming of Mitochondria in Acute Myeloid Leukemia.” Cell Reports 38, no. 1 (January 4, 2022): 110197. https://doi.org/10.1016/j.celrep.2021.110197.
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Abdel Hadi, Nadine, Emeline Boet, Airelle Lahalle, Laura Lauture, Alice Refeyton, Gabriela Reyes-Castellanos, Nathalie Caplet, et al. “Meeting Report of the 4th Biennial Metabolism and Cancer Symposium.” The FEBS Journal, November 24, 2021. https://doi.org/10.1111/febs.16295.
Sabatier, Marie, Emeline Boet, Sonia Zaghdoudi, Nathan Guiraud, Alexis Hucteau, Nathaniel Polley, Guillaume Cognet, et al. “Activation of Vitamin D Receptor Pathway Enhances Differentiating Capacity in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations.” Cancers 13, no. 20 (October 19, 2021): 5243. https://doi.org/10.3390/cancers13205243.
Poillet-Perez, Laura, Jean-Emmanuel Sarry, and Carine Joffre. “Autophagy Is a Major Metabolic Regulator Involved in Cancer Therapy Resistance.” Cell Reports 36, no. 7 (August 17, 2021): 109528. https://doi.org/10.1016/j.celrep.2021.109528.
Luna-Yolba, Raquel, Justine Marmoiton, Véronique Gigo, Xavier Marechal, Emeline Boet, Ambrine Sahal, Nathalie Alet, et al. “Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells.” Cancers 13, no. 14 (July 13, 2021): 3499. https://doi.org/10.3390/cancers13143499.
Morfoisse, Florent, Fabienne De Toni, Jeremy Nigri, Mohsen Hosseini, Audrey Zamora, Florence Tatin, Françoise Pujol, et al. “Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis.” Cancers 13, no. 12 (June 8, 2021): 2851. https://doi.org/10.3390/cancers13122851.
Stuani, Lucille, Marie Sabatier, Estelle Saland, Guillaume Cognet, Nathalie Poupin, Claudie Bosc, Florence A. Castelli, et al. “Mitochondrial Metabolism Supports Resistance to IDH Mutant Inhibitors in Acute Myeloid Leukemia.” The Journal of Experimental Medicine 218, no. 5 (May 3, 2021). https://doi.org/10.1084/jem.20200924.
Cartel, Maëlle, Pierre-Luc Mouchel, Mathilde Gotanègre, Laure David, Sarah Bertoli, Véronique Mansat-De Mas, Arnaud Besson, Jean-Emmanuel Sarry, Stéphane Manenti, and Christine Didier. “Inhibition of Ubiquitin-Specific Protease 7 Sensitizes Acute Myeloid Leukemia to Chemotherapy.” Leukemia 35, no. 2 (February 2021): 417–32. https://doi.org/10.1038/s41375-020-0878-x.
Larrue, Clément, Nathan Guiraud, Pierre-Luc Mouchel, Marine Dubois, Thomas Farge, Mathilde Gotanègre, Claudie Bosc, et al. “Adrenomedullin-CALCRL Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells.” Nature Communications 12, no. 1 (January 18, 2021): 422. https://doi.org/10.1038/s41467-020-20717-9.
Lopez-Reyes, Rosa G., Grégoire Quinet, Maria Gonzalez-Santamarta, Clément Larrue, Jean-Emmanuel Sarry, and Manuel S. Rodriguez. “Inhibition of the Proteasome and Proteaphagy Enhances Apoptosis in FLT3-ITD-Driven Acute Myeloid Leukemia.” FEBS Open Bio 11, no. 1 (January 2021): 48–60. https://doi.org/10.1002/2211-5463.12950.
Bosc, Claudie, Estelle Saland, Aurélie Bousard, Noémie Gadaud, Marie Sabatier, Guillaume Cognet, Thomas Farge, et al. “Mitochondrial Inhibitors Circumvent Adaptive Resistance to Venetoclax and Cytarabine Combination Therapy in Acute Myeloid Leukemia.” Nature Cancer 2, no. 11 (2021): 1204–23. https://doi.org/10.1038/s43018-021-00264-y.
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Layssol-Lamour, Catherine J., Jean-Emmanuel Sarry, Jean-Pierre D. Braun, Catherine Trumel, and Nathalie H. Bourgès-Abella. “Reference Values for Hematology, Plasma Biochemistry, Bone Marrow Cytology and Bone Histology of NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Immunodeficient Mice.” Journal of the American Association for Laboratory Animal Science: JAALAS, October 12, 2020. https://doi.org/10.30802/AALAS-JAALAS-20-000020.
Mouchel, Pierre-Luc, Nizar Serhan, Rémy Betous, Thomas Farge, Estelle Saland, Philippe De Medina, Jean-Sébastien Hoffmann, et al. “Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia.” Cancers 12, no. 10 (October 12, 2020): 2933. https://doi.org/10.3390/cancers12102933.
Bories, Pierre, Naïs Prade, Stéphanie Lagarde, Bastien Cabarrou, Laetitia Largeaud, Julien Plenecassagnes, Isabelle Luquet, et al. “Impact of TP53 Mutations in Acute Myeloid Leukemia Patients Treated with Azacitidine.” Edited by Francesco Bertolini. PLOS ONE 15, no. 10 (October 1, 2020): e0238795. https://doi.org/10.1371/journal.pone.0238795.
Stuani, Lucille, and Jean-Emmanuel Sarry. “Microenvironmental Aspartate Preserves Leukemic Cells from Therapy-Induced Metabolic Collapse.” Cell Metabolism 32, no. 3 (September 1, 2020): 321–23. https://doi.org/10.1016/j.cmet.2020.08.008.
Dumas, Pierre-Yves, Sarah Bertoli, Emilie Bérard, Thibaut Leguay, Suzanne Tavitian, Jean Galtier, Camille Alric, et al. “Delivering HDAC over 3 or 5 Days as Consolidation in AML Impacts Health Care Resource Consumption but Not Outcome.” Blood Advances 4, no. 16 (August 25, 2020): 3840–49. https://doi.org/10.1182/bloodadvances.2020002511.
Dumas, Pierre-Yves, Sarah Bertoli, Emilie Bérard, Laetitia Largeaud, Audrey Bidet, Eric Delabesse, Thibaut Leguay, et al. “Real-World Outcomes of Patients with Refractory or Relapsed FLT3-ITD Acute Myeloid Leukemia: A Toulouse-Bordeaux DATAML Registry Study.” Cancers 12, no. 8 (July 24, 2020): 2044. https://doi.org/10.3390/cancers12082044.
Aroua, Nesrine, Emeline Boet, Margherita Ghisi, Marie-Laure Nicolau-Travers, Estelle Saland, Ryan Gwilliam, Fabienne de Toni, et al. “Extracellular ATP and CD39 Activate cAMP-Mediated Mitochondrial Stress Response to Promote Cytarabine Resistance in Acute Myeloid Leukemia.” Cancer Discovery, July 8, 2020, CD-19-1008. https://doi.org/10.1158/2159-8290.CD-19-1008.
Serhan, Nizar, Pierre-Luc Mouchel, Philippe de Medina, Gregory Segala, Aurélie Mougel, Estelle Saland, Arnaud Rives, et al. “Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo.” Cancers 12, no. 7 (June 29, 2020): 1725. https://doi.org/10.3390/cancers12071725.
Vergez, François, Marie-Laure Nicolau-Travers, Sarah Bertoli, Jean-Baptiste Rieu, Suzanne Tavitian, Pierre Bories, Isabelle Luquet, et al. “CD34+CD38−CD123+ Leukemic Stem Cell Frequency Predicts Outcome in Older Acute Myeloid Leukemia Patients Treated by Intensive Chemotherapy but Not Hypomethylating Agents.” Cancers 12, no. 5 (May 6, 2020): 1174. https://doi.org/10.3390/cancers12051174.
Bertoli, Sarah, Pierre-Yves Dumas, Emilie Bérard, Laetitia Largeaud, Audrey Bidet, Eric Delabesse, Suzanne Tavitian, et al. “Outcome of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia before Second-Generation FLT3 Tyrosine Kinase Inhibitors: A Toulouse–Bordeaux DATAML Registry Study.” Cancers 12, no. 4 (March 25, 2020): 773. https://doi.org/10.3390/cancers12040773.
Bertoli, Sarah, Suzanne Tavitian, Emilie Bérard, Véronique Mansat-De Mas, Laetitia Largeaud, Noémie Gadaud, Jean-Baptiste Rieu, et al. “More than Ten Percent of Relapses Occur after Five Years in AML Patients with NPM1 Mutation.” Leukemia & Lymphoma, February 5, 2020, 1–4. https://doi.org/10.1080/10428194.2019.1706733.
Bosc, Claudie, Nicolas Broin, Marjorie Fanjul, Estelle Saland, Thomas Farge, Charly Courdy, Aurélie Batut, et al. “Autophagy Regulates Fatty Acid Availability for Oxidative Phosphorylation through Mitochondria-Endoplasmic Reticulum Contact Sites.” Nature Communications 11, no. 1 (2020): 4056. https://doi.org/10.1038/s41467-020-17882-2.
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36057
https://www.crct-inserm.fr/wp-content/plugins/zotpress/
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Chateauvieux, Sébastien, Anthoula Gaigneaux, Déborah Gérard, Marion Orsini, Franck Morceau, Barbora Orlikova-Boyer, Thomas Farge, et al. “Inflammation Regulates Long Non-Coding RNA-PTTG1-1:1 in Myeloid Leukemia.” Haematologica, October 3, 2019. https://doi.org/10.3324/haematol.2019.217281.
Largeaud, Laetitia, Sarah Bertoli, Emilie Bérard, Stéphanie Dufrechou, Naïs Prade, Noémie Gadaud, Suzanne Tavitian, et al. “Outcome of Relapsed/Refractory AML Patients with IDH1R132 Mutations in Real Life before the Era of IDH1 Inhibitors.” Leukemia & Lymphoma, September 30, 2019, 1–4. https://doi.org/10.1080/10428194.2019.1668937.
Berger, Eloïse, Cyrille Delpierre, Fabien Despas, Sarah Bertoli, Emilie Bérard, Oriane Bombarde, Pierre Bories, et al. “Are Social Inequalities in Acute Myeloid Leukemia Survival Explained by Differences in Treatment Utilization? Results from a French Longitudinal Observational Study among Older Patients.” BMC Cancer 19, no. 1 (September 5, 2019): 883. https://doi.org/10.1186/s12885-019-6093-3.
Hosseini, Mohsen, Hamid Rezvani, Nesrine Aroua, Claudie Bosc, Thomas Farge, Estelle Saland, Véronique Guyonnet-Dupérat, et al. “Targeting Myeloperoxidase Disrupts Mitochondrial Redox Balance and Overcomes Cytarabine Resistance in Human Acute Myeloid Leukemia.” Cancer Research, July 29, 2019. https://doi.org/10.1158/0008-5472.CAN-19-0515.
Stuani, Lucille, and Jean-Emmanuel Sarry. “Help from Outside: Cysteine to Survive in AML.” Blood 134, no. 4 (July 25, 2019): 336–38. https://doi.org/10.1182/blood.2019001580.
Stuani, Lucille, Marie Sabatier, and Jean-Emmanuel Sarry. “Exploiting Metabolic Vulnerabilities for Personalized Therapy in Acute Myeloid Leukemia.” BMC Biology 17, no. 1 (July 18, 2019): 57. https://doi.org/10.1186/s12915-019-0670-4.
Larrue, Clément, Quentin Heydt, Estelle Saland, Héléna Boutzen, Tony Kaoma, Jean-Emmanuel Sarry, Carine Joffre, and Christian Récher. “Oncogenic KIT Mutations Induce STAT3-Dependent Autophagy to Support Cell Proliferation in Acute Myeloid Leukemia.” Oncogenesis 8, no. 8 (July 16, 2019): 39. https://doi.org/10.1038/s41389-019-0148-9.
Boutin, Laetitia, Pierre Arnautou, Aurélie Trignol, Amandine Ségot, Thomas Farge, Christophe Desterke, Sabrina Soave, et al. “Mesenchymal Stromal Cells Confer Chemoresistance to Myeloid Leukemia Blasts through Side Population Functionality and ABC Transporter Activation.” Haematologica, July 9, 2019. https://doi.org/10.3324/haematol.2018.214379.
Bertoli, Sarah, Suzanne Tavitian, Pierre Bories, Isabelle Luquet, Eric Delabesse, Thibault Comont, Audrey Sarry, Françoise Huguet, Emilie Bérard, and Christian Récher. “Outcome of Patients Aged 60-75 Years with Newly Diagnosed Secondary Acute Myeloid Leukemia: A Single-Institution Experience.” Cancer Medicine, June 7, 2019. https://doi.org/10.1002/cam4.2020.
Largeaud, Laetitia, Emilie Bérard, Sarah Bertoli, Stéphanie Dufrechou, Naïs Prade, Noémie Gadaud, Suzanne Tavitian, et al. “Outcome of AML Patients with IDH2 Mutations in Real World before the Era of IDH2 Inhibitors.” Leukemia Research 81 (April 27, 2019): 82–87. https://doi.org/10.1016/j.leukres.2019.04.010.
Bertoli, Sarah, Etienne Paubelle, Emilie Bérard, Estelle Saland, Xavier Thomas, Suzanne Tavitian, Marie-Virginie Larcher, et al. “Ferritin Heavy/Light Chain (FTH1/FTL) Expression, Serum Ferritin Levels, and Their Functional as Well as Prognostic Roles in Acute Myeloid Leukemia.” European Journal of Haematology 102, no. 2 (February 2019): 131–42. https://doi.org/10.1111/ejh.13183.
Bertoli, Sarah, Suzanne Tavitian, Emilie Berard, Noemie Gadaud, Isabelle Luquet, Anne Huynh, Audrey Sarry, Françoise Huguet, and Christian Récher. “Outcome of Relapsed or Refractory Acute Myeloid Leukemia Treated with Intensive Salvage Chemotherapy in Real Life in Comparison to Intermediate Dose Cytarabine in Phase 3 Studies.” Leukemia & Lymphoma 60, no. 1 (2019): 238–41. https://doi.org/10.1080/10428194.2018.1464156.
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