{"id":39101,"date":"2021-11-05T10:48:38","date_gmt":"2021-11-05T09:48:38","guid":{"rendered":"https:\/\/www.crct-inserm.fr\/v2\/?page_id=39101"},"modified":"2024-01-08T14:49:42","modified_gmt":"2024-01-08T13:49:42","slug":"oncosarc","status":"publish","type":"page","link":"https:\/\/www.crct-inserm.fr\/oncosarc\/","title":{"rendered":"ONCOSARC"},"content":{"rendered":"

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\u00c9quipe
Fr\u00e9d\u00e9ric Chibon<\/h1>\n

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ONCOSARC :<\/strong><\/h2>\n

Oncogen\u00e8se des sarcomes<\/strong><\/h2>\n

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Le laboratoire d\u2019Excellence Toulouse Cancer est un projet qui vise \u00e0 comprendre les m\u00e9canismes de r\u00e9sistance et de rechute dans les cancers.<\/p>\n

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Les sp\u00e9cificit\u00e9s
<\/strong>de notre axe de recherches<\/h2>\n

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Sarcome<\/p>\n

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Diff\u00e9renciation<\/p>\n

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Diagnostic<\/p>\n

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G\u00e9nome<\/p>\n

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Oncogen\u00e8se<\/p>\n

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Pronostic<\/p>\n

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Chromosome<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

Metastase<\/p>\n

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Cellule tumorale hybride<\/p>\n

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Mitose<\/p>\n

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Traitement<\/p>\n

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H\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9<\/p>\n

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DES PROJETS<\/strong>
DE RECHERCHE<\/h2>\n

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LES FOCUS<\/strong>
DE L\u2019\u00c9QUIPE<\/h2>\n

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D\u00e9couvrir<\/h4>\n

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Comprendre<\/h4>\n

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Participer<\/h4>\n

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En live<\/strong><\/h2>\n

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\n\t\n \n
\n \n
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\n OncoSarc Lab<\/span>\n <\/span>\n Suivre<\/span>\n \n <\/path><\/svg>4<\/span>\n <\/path><\/svg>26<\/span>\n <\/span>\n <\/p>\n

\n Fred Chibon's team at the @crctoncopole specialized in #Sarcoma Oncogenesis ! <\/p>\n <\/div>\n

\n
\n <\/path><\/svg> <\/div>\n \"OncoSarc\"\n <\/div>\n <\/a>\n<\/div>\n\n
\n \n
\n\n \n
\n
\n \n \"OncoSarc;\n <\/a>\n \n OncoSarc Lab<\/a>\n @OncoSarc<\/a>\n \n \t\t ·<\/span>\n\t
\n 14 D\u00e9c 2020 1338489614923915277<\/span><\/a>\n <\/div>\n <\/div>\n
\n <\/path><\/svg> <\/div>\n <\/div>\n\n
\n \t\t\t\t

Nous recrutons!
\n
\nLe groupe \"Oncogen\u00e8se des sarcomes\" de l'ONCOPOLE de Toulouse cherche \u00e0 se renforcer, pour d\u00e9velopper de nouveaux axes. Recherchons CR\/DR INSERM.
\nFaites passer l'info, contactez moi!
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Frezza, Anna Maria, Silvia Stacchiotti, Frederic Chibon, Jean-Michelle Coindre, Antoine Italiano, Cleofe Romagnosa, Silvia Bagué, et al. “CINSARC in High-Risk Soft Tissue Sarcoma Patients Treated with Neoadjuvant Chemotherapy: Results from the ISG-STS 1001 Study.” Cancer Medicine<\/i> 12, no. 2 (January 2023): 1350–57. https:\/\/doi.org\/10.1002\/cam4.5015<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n

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Croce, Sabrina, and Frédéric Chibon. “Molecular Prognostication of Uterine Smooth Muscle Neoplasms: From CGH<\/span> Array to CINSARC<\/span> Signature and Beyond.” Genes, Chromosomes and Cancer<\/i>, November 11, 2020, gcc.22906. https:\/\/doi.org\/10.1002\/gcc.22906<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lesluyes, Tom, and Frédéric Chibon. “A Global and Integrated Analysis of CINSARC-Associated Genetic Defects.” Cancer Research<\/i>, October 6, 2020, canres.0512.2020. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-0512<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Cissé, Madi Y., Samuel Pyrdziak, Nelly Firmin, Laurie Gayte, Maud Heuillet, Floriant Bellvert, Maryse Fuentes, et al. “Targeting MDM2-Dependent Serine Metabolism as a Therapeutic Strategy for Liposarcoma.” Science Translational Medicine<\/i> 12, no. 547 (June 10, 2020): eaay2163. https:\/\/doi.org\/10.1126\/scitranslmed.aay2163<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Merle, Candice, Noémie Thébault, Sophie LeGuellec, Jessica Baud, Gaëlle Pérot, Tom Lesluyes, Lucile Delespaul, Lydia Lartigue, and Frédéric Chibon. “Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion.” Cancers<\/i> 12, no. 5 (May 19, 2020): 1281. https:\/\/doi.org\/10.3390\/cancers12051281<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lartigue, Lydia, Candice Merle, Pauline Lagarde, Lucile Delespaul, Tom Lesluyes, Sophie Le Guellec, Gaelle Pérot, Laura Leroy, Jean-Michel Coindre, and Frédéric Chibon. “Genome Remodeling upon Mesenchymal Tumor Cell Fusion Contributes to Tumor Progression and Metastatic Spread.” Oncogene<\/i> 39, no. 21 (May 2020): 4198–4211. https:\/\/doi.org\/10.1038\/s41388-020-1276-6<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mattei, Jean Camille, Corinne Bouvier-Labit, Doriane Barets, Nicolas Macagno, Mathieu Chocry, Frédéric Chibon, Philippe Morando, et al. “Pan Aurora Kinase Inhibitor: A Promising Targeted-Therapy in Dedifferentiated Liposarcomas With Differential Efficiency Depending on Sarcoma Molecular Profile.” Cancers<\/i> 12, no. 3 (March 3, 2020). https:\/\/doi.org\/10.3390\/cancers12030583<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Jakob, Jens, Tom Lesluyes, Anna Simeonova-Chergou, Frederik Wenz, Peter Hohenberger, Frederic Chibon, and Sophie Le Guellec. “Impact of Preoperative Treatment on the CINSARC Prognostic Signature: Translational Research Results from a Phase 1 Trial of the German Interdisciplinary Sarcoma Group (GISG 03).” Strahlentherapie Und Onkologie: Organ Der Deutschen Rontgengesellschaft ... [et Al]<\/i> 196, no. 3 (March 2020): 280–85. https:\/\/doi.org\/10.1007\/s00066-019-01543-5<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Salas, Sébastien, and Frédéric Chibon. “Biology and signaling pathways involved in the oncogenesis of desmoid tumors.” Bulletin Du Cancer<\/i>, January 16, 2020. https:\/\/doi.org\/10.1016\/j.bulcan.2019.12.003<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Dufresne, A., T. Lesluyes, C. Ménétrier-Caux, M. Brahmi, E. Darbo, M. Toulmonde, A. Italiano, et al. “Specific Immune Landscapes and Immune Checkpoint Expressions in Histotypes and Molecular Subtypes of Sarcoma.” OncoImmunology<\/i> 9, no. 1 (January 1, 2020): 1792036. https:\/\/doi.org\/10.1080\/2162402X.2020.1792036<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Delespaul, Lucile, Caroline Gélabert, Tom Lesluyes, Sophie Le Guellec, Gaëlle Pérot, Laura Leroy, Jessica Baud, Candice Merle, Lydia Lartigue, and Frédéric Chibon. “Cell–Cell Fusion of Mesenchymal Cells with Distinct Differentiations Triggers Genomic and Transcriptomic Remodelling toward Tumour Aggressiveness.” Scientific Reports<\/i> 10, no. 1 (2020): 21634. https:\/\/doi.org\/10.1038\/s41598-020-78502-z<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Filleron, Thomas, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, et al. “Value of Peri-Operative Chemotherapy in Patients with CINSARC High-Risk Localized Grade 1 or 2 Soft Tissue Sarcoma: Study Protocol of the Target Selection Phase III CHIC-STS Trial.” BMC Cancer<\/i> 20, no. 1 (2020): 716. https:\/\/doi.org\/10.1186\/s12885-020-07207-3<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Guérin, Amandine, Delphine Martire, Eva Trenquier, Tom Lesluyes, Sébastien Sagnol, Marine Pratlong, Elise Lefebvre, Fréderic Chibon, Pascal Santa Barbara, and Sandrine Faure. “LIX1 Regulates YAP Activity and Controls Gastrointestinal Cancer Cell Plasticity.” Journal of Cellular and Molecular Medicine<\/i> 24, no. 16 (2020): 9244–54. https:\/\/doi.org\/10.1111\/jcmm.15569<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Croce, Sabrina, Tom Lesluyes, Carine Valle, Loubna M’Hamdi, Noémie Thébault, Gaëlle Pérot, Eberhard Stoeckle, et al. “The Nanocind Signature Is an Independent Prognosticator of Recurrence and Death in Uterine Leiomyosarcomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research<\/i> 26, no. 4 (15 2020): 855–61. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-2891<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n

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20signature%20outperforming%20histology-based%20grading%20system%20by%20identifying%20high-risk%20patients%20in%20every%20grade%2C%20even%20in%20those%20considered%20as%20low.%20CINSARC%20is%20an%20expression-based%20signature%20related%20to%20mitosis%20and%20chromosome%20integrity%20with%20prognostic%20value%20in%20a%20wide%20range%20of%20cancers%20additional%20to%20sarcoma.%20First%20developed%20with%20frozen%20material%2C%20CINSARC%20is%20now%20coupled%20with%20NanoString%20technology%20allowing%20evaluation%20from%20FFPE%20blocks%20used%20in%20clinical%20practice.%20Consequently%2C%20CINSARC%20is%20currently%20evaluated%20in%20clinical%20trials%20with%20a%20dual%20objective%20of%20demonstrating%20the%20benefit%20of%20chemotherapy%20in%20sarcoma%20patients%20and%20testing%20its%20response%20prediction.%20Considering%20its%20overarching%20value%20in%20oncology%2C%20its%20development%20is%20welcome%20in%20any%20cancers%20where%20the%20prognostication%20needs%20to%20be%20improved.%22%2C%22date%22%3A%2202%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.1002%5C%2Fgcc.22703%22%2C%22ISSN%22%3A%221098-2264%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22CF9MRXB4%22%5D%2C%22dateModified%22%3A%222021-07-22T11%3A24%3A23Z%22%7D%7D%5D%7D<\/span>\n\n\t\t\t\t
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Delespaul, Lucile, Candice Merle, Tom Lesluyes, Pauline Lagarde, Sophie Le Guellec, Gaëlle Pérot, Jessica Baud, et al. “Fusion-Mediated Chromosomal Instability Promotes Aneuploidy Patterns That Resemble Human Tumors.” Oncogene<\/i>, July 3, 2019. https:\/\/doi.org\/10.1038\/s41388-019-0859-6<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mauduit, Olivier, Vanessa Delcroix, Tom Lesluyes, Gaëlle Pérot, Pauline Lagarde, Lydia Lartigue, Jean-Yves Blay, and Frédéric Chibon. “Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas.” Cancers<\/i> 11, no. 7 (July 1, 2019). https:\/\/doi.org\/10.3390\/cancers11070922<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lesluyes, Tom, Jessica Baud, Gaëlle Pérot, Céline Charon-Barra, Axel You, Isabelle Valo, Céline Bazille, et al. “Genomic and Transcriptomic Comparison of Post-Radiation versus Sporadic Sarcomas.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc<\/i>, June 26, 2019. https:\/\/doi.org\/10.1038\/s41379-019-0300-2<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Chibon, Frédéric, Elodie Darbo, and Gaëlle Pérot. “Leiomyosarcomas: Whole Genome Sequencing for a Whole Biology Characterization.” Current Opinion in Oncology<\/i>, April 24, 2019. https:\/\/doi.org\/10.1097\/CCO.0000000000000550<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Le Loarer, François, Sophie Laffont, Tom Lesluyes, Franck Tirode, Cristina Antonescu, Anne-Catherine Baglin, Lucile Delespaul, et al. “Clinicopathologic and Molecular Features of a Series of 41 Biphenotypic Sinonasal Sarcomas Expanding Their Molecular Spectrum.” The American Journal of Surgical Pathology<\/i>, March 1, 2019. https:\/\/doi.org\/10.1097\/PAS.0000000000001238<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Vitiello, Gerardo A., Timothy G. Bowler, Mengyuan Liu, Benjamin D. Medina, Jennifer Q. Zhang, Nesteene J. Param, Jennifer K. Loo, et al. “Differential Immune Profiles Distinguish the Mutational Subtypes of Gastrointestinal Stromal Tumor.” The Journal of Clinical Investigation<\/i>, February 14, 2019. https:\/\/doi.org\/10.1172\/JCI124108<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Mauduit, Olivier, Céline Brulard, Tom Lesluyes, Vanessa Delcroix, Gaëlle Pérot, Nina Choublier, Mickael Michaud, et al. “RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas.” Cancers<\/i> 11, no. 1 (January 11, 2019). https:\/\/doi.org\/10.3390\/cancers11010081<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Valentin, T., T. Lesluyes, S. Le Guellec, and F. Chibon. “Chemotherapy in Localized Soft Tissue Sarcoma: Will We Soon Have to Treat Grade 1 Tumors? Update on CINSARC Performances.” Annals of Oncology: Official Journal of the European Society for Medical Oncology<\/i> 30, no. 1 (January 1, 2019): 153–55. https:\/\/doi.org\/10.1093\/annonc\/mdy465<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Timbergen, Milea J. M., Matthijs L. Janssen, Cornelis Verhoef, Dirk J. Grünhagen, Frederic Chibon, Marcel Smid, Stefan Sleijfer, and Erik A. C. Wiemer. “Wnt Targets Genes Are Not Differentially Expressed in Desmoid Tumors Bearing Different Activating β-Catenin Mutations.” European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology<\/i> 45, no. 4 (2019): 691–98. https:\/\/doi.org\/10.1016\/j.ejso.2018.09.019<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Croce, Sabrina, Tom Lesluyes, Lucile Delespaul, Benjamin Bonhomme, Gaëlle Pérot, Valérie Velasco, Laetitia Mayeur, et al. “GREB1-CTNNB1 Fusion Transcript Detected by RNA-Sequencing in a Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Novel CTNNB1 Rearrangement.” Genes, Chromosomes & Cancer<\/i> 58, no. 3 (2019): 155–63. https:\/\/doi.org\/10.1002\/gcc.22694<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Chibon, Frederic, Tom Lesluyes, Thibaud Valentin, and Sophie Le Guellec. “CINSARC Signature as a Prognostic Marker for Clinical Outcome in Sarcomas and Beyond.” Genes, Chromosomes & Cancer<\/i> 58, no. 2 (2019): 124–29. https:\/\/doi.org\/10.1002\/gcc.22703<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n

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LES MEMBRES DE L\u2019\u00c9QUIPE<\/strong><\/h2>\n

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GANGLOFF Dimitri<\/a><\/div>\n
Clinicien Chercheur \/ Researcher hospital practitioner<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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Lise Pomi\u00e8s<\/a><\/div>\n
Ing\u00e9nieur de laboratoire \/ laboratory engineer<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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Fran\u00e7ois Poumeaud<\/a><\/div>\n
Master \/ Master student<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Lucile Delespaul<\/a><\/div>\n
Ing\u00e9nieur de laboratoire \/ laboratory engineer<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Natacha Roussel<\/a><\/div>\n
Doctorant \/ PhD student<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Valentin Thibaud<\/a><\/div>\n
Clinicien Chercheur \/ Researcher hospital practitioner<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Fr\u00e9d\u00e9ric Chibon<\/a><\/div>\n
Chercheur statutaire \/ permanent scientist<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Ga\u00eblle P\u00e9rot<\/a><\/div>\n
Ing\u00e9nieur de laboratoire \/ laboratory engineer<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Sofia Galanou<\/a><\/div>\n
Doctorant \/ PhD student<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Anne Gomez-Brouchet<\/a><\/div>\n
Enseignant chercheur \/ University researcher<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n <\/div>\n<\/div><\/div>\n\n
<\/div><\/div>\n\n