{"id":37192,"date":"2021-10-19T11:53:11","date_gmt":"2021-10-19T09:53:11","guid":{"rendered":"https:\/\/www.crct-inserm.fr\/v2\/?page_id=37192"},"modified":"2024-01-08T14:35:01","modified_gmt":"2024-01-08T13:35:01","slug":"inov","status":"publish","type":"page","link":"https:\/\/www.crct-inserm.fr\/inov\/","title":{"rendered":"INOV"},"content":{"rendered":"

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\u00c9quipe
mARC POIROT & SANDRINE SILVENTE-POIROT<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.0″ _module_preset=”448e09ae-9652-4ead-bc5f-152c7adf1202″ header_2_font=”Open Sans||||||||” global_colors_info=”{}”]<\/p>\n

\u00a0<\/h2>\n

INOV : <\/strong><\/h2>\n

M\u00e9tabolisme du cholest\u00e9rol et<\/strong>
innovations th\u00e9rapeutiques<\/strong><\/h2>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” width=”50%” custom_padding=”23px|||||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.crct-inserm.fr\/wp-content\/uploads\/2021\/08\/logo-ligue-contre-le-cancer.jpg” title_text=”logo-ligue-contre-le-cancer” _builder_version=”4.21.0″ _module_preset=”default” width=”50%” max_width=”50%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _module_preset=”default” text_font_size=”22px” custom_margin=”30px|||||” custom_padding=”||3px|||” global_colors_info=”{}”]<\/p>\n

Equipe labellis\u00e9e Ligue contre le cancer<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_stops=”rgba(43,135,218,0) 50%|#f2efef 50%” background_color_gradient_start=”rgba(43,135,218,0)” background_color_gradient_start_position=”50%” background_color_gradient_end=”#f2efef” background_color_gradient_end_position=”0%” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_row disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px||0px|||” disabled=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=FkQuawiGWUw” image_src=”https:\/\/www.crct-inserm.fr\/wp-content\/uploads\/2021\/03\/video.jpg” _builder_version=”4.16″ _module_preset=”default” width=”80%” module_alignment=”center” global_colors_info=”{}”][\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#f2efef” custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.0″ _module_preset=”448e09ae-9652-4ead-bc5f-152c7adf1202″ global_colors_info=”{}”]<\/p>\n

Les sp\u00e9cificit\u00e9s<\/strong><\/h2>\n

de notre axe de recherche<\/h2>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”5px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.0″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Nous explorons le r\u00f4le du m\u00e9tabolisme du cholest\u00e9rol dans le contr\u00f4le de la progression tumorale et dans la r\u00e9sistance aux th\u00e9rapies dans plusieurs cancers (sein, peau, thyro\u00efde, leuc\u00e9mies). Nous \u00e9tudions les propri\u00e9t\u00e9s biologiques et les voies de biosynth\u00e8se de deux m\u00e9tabolites que nous avons d\u00e9couverts: la dendrog\u00e9nine A (DDA) et l\u2019oncost\u00e9rone (OCDO) qui sont respectivement des m\u00e9tabolites suppresseur et promoteur de tumeurs. Ces \u00e9tudes ont pour but ultime le d\u00e9veloppement de nouveaux candidats m\u00e9dicaments et d\u2019outils th\u00e9ranostiques pour de nouvelles th\u00e9rapies cibl\u00e9es et personnalis\u00e9e des cancers. Elles permettront en outre de d\u00e9finir le r\u00f4le de la composante st\u00e9rol de l\u2019alimentation sur le d\u00e9veloppement de certains cancers.<\/p>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

oncometabolism<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

cholesterol<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

oxysterol<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

oncosterone<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

v\u00e9sicules de s\u00e9cr\u00e9tion<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

exosomes<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

dendrogenine<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

recepteurs nucl\u00e9aires<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

enzymes<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_orientation=”center” custom_margin=”||15px||false|false” custom_padding=”15px||15px||false|false” border_color_bottom=”#F19532″ border_width_left=”5px” border_color_left=”#F19532″ global_colors_info=”{}”]<\/p>\n

imagerie m\u00e9tabolique<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”448e09ae-9652-4ead-bc5f-152c7adf1202″ global_colors_info=”{}”]<\/p>\n

DES PROJETS<\/strong>
DE RECHERCHE<\/h2>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blog fullwidth=”off” posts_number=”5″ include_categories=”312″ use_manual_excerpt=”off” show_more=”on” show_author=”off” show_date=”off” show_categories=”off” masonry_tile_background_color=”#f2efef” _builder_version=”4.16″ _module_preset=”default” header_level=”h3″ header_font=”|800|||||||” header_font_size=”20px” body_font_size=”20px” read_more_text_color=”#5EC7ED” read_more_font_size=”20px” read_more_line_height=”3em” background_enable_color=”off” border_width_all=”0px” global_colors_info=”{}”][\/et_pb_blog][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”448e09ae-9652-4ead-bc5f-152c7adf1202″ global_colors_info=”{}”]<\/p>\n

LES FOCUS<\/strong>
DE L\u2019\u00c9QUIPE<\/h2>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_stops=”#ffffff 50%|rgba(174,227,246,0) 50%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#ffffff” background_color_gradient_start_position=”50%” background_color_gradient_end=”rgba(174,227,246,0)” background_color_gradient_end_position=”0%” background_image=”https:\/\/www.crct-inserm.fr\/wp-content\/uploads\/2021\/03\/Filets-bleu-actu.png” background_size=”contain” background_position=”bottom_center” custom_padding=”0px|||||” saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”4ae3b26e-eab0-4b6f-bd7b-05f173fca79b” custom_margin=”||-4px||false|false” header_font_size_tablet=”” header_font_size_phone=”” header_font_size_last_edited=”on|desktop” header_2_font_size_tablet=”” header_2_font_size_phone=”” header_2_font_size_last_edited=”on|desktop” header_4_font_size_tablet=”” header_4_font_size_phone=”” header_4_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

D\u00e9couvrir<\/h4>\n

[\/et_pb_text][et_pb_post_slider posts_number=”5″ include_categories=”1006″ show_arrows=”off” use_manual_excerpt=”off” excerpt_length=”0″ show_meta=”off” image_placement=”top” use_bg_overlay=”off” use_text_overlay=”off” dot_nav_custom_color=”#5EC7ED” _builder_version=”4.16″ _module_preset=”412cf9f9-c22e-468d-92e3-f93d454642a9″ header_font=”Open Sans|600|||||||” header_text_color=”#5EC7ED” header_font_size=”20px” header_line_height=”1.2em” body_font=”Open Sans||||||||” body_text_align=”left” body_text_color=”#505659″ body_font_size=”18px” background_color=”#FFFFFF” custom_button=”on” button_text_size=”18px” button_bg_color=”#5EC7ED” button_border_width=”0px” button_border_radius=”0px” button_use_icon=”off” button_alignment=”center” button_custom_margin=”20px||0px||false|false” button_custom_padding=”10px|50px|10px|50px|true|true” custom_padding=”0px|||||” header_font_size_tablet=”” header_font_size_phone=”22px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”” body_font_size_phone=”18px” body_font_size_last_edited=”on|phone” border_color_all_image=”#ffffff” border_width_bottom_image=”15px” text_shadow_style=”preset4″ text_shadow_vertical_length=”0em” global_colors_info=”{}”][\/et_pb_post_slider][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.17.3″ _module_preset=”4ae3b26e-eab0-4b6f-bd7b-05f173fca79b” custom_margin=”||-3px||false|false” global_colors_info=”{}”]<\/p>\n

Comprendre<\/h4>\n

[\/et_pb_text][et_pb_post_slider posts_number=”5″ include_categories=”1109,1216″ show_arrows=”off” use_manual_excerpt=”off” excerpt_length=”0″ show_meta=”off” image_placement=”top” use_bg_overlay=”off” use_text_overlay=”off” dot_nav_custom_color=”#5EC7ED” show_image_tablet=”” show_image_phone=”” show_image_last_edited=”on|phone” disabled_on=”off|off|off” _builder_version=”4.19.0″ _module_preset=”default” header_font=”Open Sans|600|||||||” header_text_color=”#5EC7ED” header_font_size=”20px” header_line_height=”1.2em” body_font=”Open Sans||||||||” body_text_align=”left” body_text_color=”#505659″ body_font_size=”18px” background_color=”#FFFFFF” custom_button=”on” button_text_size=”18px” button_bg_color=”#5EC7ED” button_border_width=”0px” button_border_radius=”0px” button_use_icon=”off” button_alignment=”center” button_custom_margin=”20px||0px||false|false” button_custom_padding=”10px|50px|10px|50px|true|true” custom_padding=”0px|||||” header_font_size_tablet=”” header_font_size_phone=”22px” header_font_size_last_edited=”on|phone” border_width_bottom_image=”15px” border_color_bottom_image=”#ffffff” text_shadow_style=”preset4″ text_shadow_vertical_length=”0em” global_colors_info=”{}”][\/et_pb_post_slider][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”4ae3b26e-eab0-4b6f-bd7b-05f173fca79b” custom_margin=”||-4px||false|false” global_colors_info=”{}”]<\/p>\n

Participer<\/h4>\n

[\/et_pb_text][et_pb_post_slider posts_number=”5″ include_categories=”1265,1319″ show_arrows=”off” use_manual_excerpt=”off” excerpt_length=”0″ show_meta=”off” image_placement=”top” use_bg_overlay=”off” use_text_overlay=”off” dot_nav_custom_color=”#5EC7ED” disabled_on=”off|off|off” _builder_version=”4.21.0″ _module_preset=”default” header_font=”Open Sans|600|||||||” header_text_color=”#5EC7ED” header_font_size=”20px” header_line_height=”1.2em” body_font=”Open Sans||||||||” body_text_align=”left” body_text_color=”#505659″ body_font_size=”18px” background_color=”#FFFFFF” custom_button=”on” button_text_size=”18px” button_bg_color=”#5EC7ED” button_border_width=”0px” button_border_radius=”0px” button_use_icon=”off” button_alignment=”center” button_custom_margin=”20px||0px||false|false” button_custom_padding=”10px|50px|10px|50px|true|true” custom_padding=”0px|||||” header_font_size_tablet=”” header_font_size_phone=”22px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”” body_font_size_phone=”18px” body_font_size_last_edited=”on|phone” border_width_bottom_image=”15px” border_color_bottom_image=”#ffffff” text_shadow_style=”preset4″ text_shadow_vertical_length=”0em” global_colors_info=”{}”][\/et_pb_post_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”448e09ae-9652-4ead-bc5f-152c7adf1202″ global_colors_info=”{}”]<\/p>\n

En live<\/h2>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][et_pb_code _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”]\n\n

\n\t\n \n
\n \n
\n

\n Marc Poirot<\/span>\n <\/span>\n Suivre<\/span>\n \n <\/path><\/svg>224<\/span>\n <\/path><\/svg>112<\/span>\n <\/span>\n <\/p>\n

\n research director at Inserm (french national institute of health)\nmain discoveries: a new metabolic branch on the cholesterol pathway: dendrogenins, oncosterone <\/p>\n <\/div>\n

\n
\n <\/path><\/svg> <\/div>\n \"PoirotMarc\"\n <\/div>\n <\/a>\n<\/div>\n\n
\n \n
\n\n
\n <\/path><\/svg>Retweeter sur Twitter<\/span><\/a>\n Marc Poirot Retweet\u00e9<\/a>\n<\/div>\n\n
\n
\n \n \"FrezzaLab;\n <\/a>\n \n FrezzaLab<\/a>\n @FrezzaLab<\/a>\n \n \t\t ·<\/span>\n\t
\n 19 Mar 1770161104590684293<\/span><\/a>\n <\/div>\n <\/div>\n
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Poirot, Marc, Luigi Iuliano, William J. Griffiths, and Gerard Lizard. “11th ENOR Meeting: Oxysterols in Human Health and Diseases.” The Journal of Steroid Biochemistry and Molecular Biology<\/i> 239 (February 27, 2024): 106495. https:\/\/doi.org\/10.1016\/j.jsbmb.2024.106495<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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deMedina, Philippe, Silia Ayadi, Khadijetou Diallo, Julio Buñay, Laly Pucheu, Regis Soulès, Michel Record, et al. “The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases.” Advances in Experimental Medicine and Biology<\/i> 1440 (2024): 149–61. https:\/\/doi.org\/10.1007\/978-3-031-43883-7_8<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n

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Dieudonné, Arnaud, Clément Bailly, Florent Cachin, Agathe Edet-Sanson, Françoise Kraeber-Bodéré, Sébastien Hapdey, Charles Merlin, et al. “Dosimetry for Targeted Radionuclide Therapy in Routine Clinical Practice: Experts Advice vs. Clinical Evidence.” European Journal of Nuclear Medicine and Molecular Imaging<\/i>, December 19, 2023. https:\/\/doi.org\/10.1007\/s00259-023-06568-8<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Ayadi, Silia, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, and Philippe de Medina. “27-Hydroxylation of Oncosterone by CYP27A1 Switches Its Activity from pro-Tumor to Anti-Tumor.” Journal of Lipid Research<\/i> 64, no. 12 (December 2023): 100479. https:\/\/doi.org\/10.1016\/j.jlr.2023.100479<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Maronnier, Quentin, Frédéric Courbon, and Olivier Caselles. “Evaluation of a Method Based on Synthetic Data Inserted into Raw Data Prior to Reconstruction for the Assessment of PET Scanners.” EJNMMI Physics<\/i> 9, no. 1 (October 1, 2022): 68. https:\/\/doi.org\/10.1186\/s40658-022-00496-6<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Clement, Dominique, Shaunak Navalkissoor, Rajaventhan Srirajaskanthan, Frédéric Courbon, Lawrence Dierickx, Amy Eccles, Valerie Lewington, et al. “Efficacy and Safety of 177Lu‑DOTATATE in Patients with Advanced Pancreatic Neuroendocrine Tumours: Data from the NETTER-R International, Retrospective Study.” European Journal of Nuclear Medicine and Molecular Imaging<\/i> 49, no. 10 (August 2022): 3529–37. https:\/\/doi.org\/10.1007\/s00259-022-05771-3<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “Celebrating the 10th Anniversary of the Creation of the European Network for Oxysterol Research (ENOR).” The Journal of Steroid Biochemistry and Molecular Biology<\/i> 221 (July 2022): 106114. https:\/\/doi.org\/10.1016\/j.jsbmb.2022.106114<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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deMedina, Philippe, Sandrine Silvente-Poirot, and Marc Poirot. “Oxysterols Are Potential Physiological Regulators of Ageing.” Ageing Research Reviews<\/i> 77 (May 2022): 101615. https:\/\/doi.org\/10.1016\/j.arr.2022.101615<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Record, Michel, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, et al. “Targeting the Liver X Receptor with Dendrogenin A Differentiates Tumour Cells to Secrete Immunogenic Exosome-Enriched Vesicles.” Journal of Extracellular Vesicles<\/i> 11, no. 4 (April 2022): e12211. https:\/\/doi.org\/10.1002\/jev2.12211<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Sabatier, Renaud, Cécile Vicier, Séverine Garnier, Arnaud Guille, Nadine Carbuccia, Nicolas Isambert, Florence Dalenc, et al. “Circulating Tumor DNA Predicts Efficacy of a Dual AKT\/P70S6K Inhibitor (LY2780301) plus Paclitaxel in Metastatic Breast Cancer: Plasma Analysis of the TAKTIC Phase IB\/II Study.” Molecular Oncology<\/i>, February 5, 2022. https:\/\/doi.org\/10.1002\/1878-0261.13188<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Websdale, Alex, Yi Kiew, Philip Chalmers, Xinyu Chen, Giorgia Cioccoloni, Thomas A. Hughes, Xinyu Luo, et al. “Pharmacologic and Genetic Inhibition of Cholesterol Esterification Enzymes Reduces Tumour Burden: A Systematic Review and Meta-Analysis of Preclinical Models.” Biochemical Pharmacology<\/i> 196 (February 2022): 114731. https:\/\/doi.org\/10.1016\/j.bcp.2021.114731<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Poirot, Marc. “Sterol Metabolism and Cancer.” Biochemical Pharmacology<\/i> 196 (February 2022): 114843. https:\/\/doi.org\/10.1016\/j.bcp.2021.114843<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Khallouki, Farid, Somayya Saber, Toufik Bouddine, Lhoussain Hajji, Bachir Elbouhali, Sandrine Silvente-Poirot, and Marc Poirot. “In Vitro and In Vivo Oxidation and Cleavage Products of Tocols: From Chemical Tuners to ‘VitaminEome’ Therapeutics. A Narrative Review.” Food Bioscience<\/i> 49 (2022): 101839. https:\/\/doi.org\/10.1016\/j.fbio.2022.101839<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Lambert, Marie, Lawrence Dierickx, Séverine Brillouet, Frédéric Courbon, and Etienne Chatelut. “Comparison of Two Types of Amino Acid Solutions on 177Lu-Dotatate Pharmacokinetics and Pharmacodynamics in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors.” Current Radiopharmaceuticals<\/i> 15, no. 2 (2022): 164–72. https:\/\/doi.org\/10.2174\/1874471015666211228123525<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n

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deMedina, Philippe, Khadijetou Diallo, Emilie Huc-Claustre, Mehdi Attia, Régis Soulès, Sandrine Silvente-Poirot, and Marc Poirot. “The 5,6-Epoxycholesterol Metabolic Pathway in Breast Cancer: Emergence of New Pharmacological Targets.” British Journal of Pharmacology<\/i> 178, no. 16 (August 2021): 3248–60. https:\/\/doi.org\/10.1111\/bph.15205<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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rulago%20campestris%20%28Besser%29%20Grecescu%20%28field%20ferula%29%20were%20screened%20by%20HPLC%20analysis%20for%20their%20respective%20content%20of%20umbelliprenin%20in%20extracts%20obtained%20with%20different%20solvent%20mixtures%20and%20by%20maceration%20and%20ultrasound-assisted%20processes.%20EtOH%20was%20shown%20to%20be%20the%20best%20solvent%2C%20providing%20umbelliprenin%20yields%20ranging%20from%201.7%25%20to%2014.4%25%20%28with%20respect%20to%20the%20total%20amount%20of%20extract%20obtained%29.%20Extracts%20with%20the%20highest%20content%20of%20this%20farnesyloxycoumarin%20were%20then%20assayed%20as%20modulators%20of%20melanogenesis%20in%20cultured%20murine%20Melan%20A%20cells%20employing%20the%20same%20umbelliprenin%20obtained%20by%20chemical%20synthesis%20as%20the%20reference.%20A%20parallelism%20between%20the%20content%20of%20the%20coumarin%20and%20the%20recorded%20depigmenting%20effect%20%2860%25%20for%20the%20EtOH%20extract%20of%20F.%20campestris%20as%20the%20best%20value%29%20was%20revealed%20for%20all%20plants%20extracts%20when%20applied%20at%20a%20dose%20of%20100%20%5Cu03bcg%5C%2FmL.%20Our%20results%20demonstrate%20that%20the%20same%20potential%20of%20umbelliprenin%20can%20be%20ascribed%20also%20to%20umbelliprenin-enriched%20plant%20extracts%20which%20reinforces%20enforce%20the%20widespread%20use%20of%20phyto-preparations%20for%20cosmetic%20purposes%20%28e.g.%2C%20A.%20graveolens%29.%22%2C%22date%22%3A%22Jan%2030%2C%202019%22%2C%22language%22%3A%22eng%22%2C%22DOI%22%3A%2210.3390%5C%2Fmolecules24030501%22%2C%22ISSN%22%3A%221420-3049%22%2C%22url%22%3A%22%22%2C%22collections%22%3A%5B%22S3JJUU84%22%5D%2C%22dateModified%22%3A%222021-04-26T15%3A22%3A58Z%22%7D%7D%5D%7D<\/span>\n\n\t\t\t\t
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Soulès, Régis, Fabien Audouard-Combe, Emilie Huc-Claustre, Philippe de Medina, Arnaud Rives, Etienne Chatelut, Florence Dalenc, et al. “A Fast UPLC-HILIC Method for an Accurate Quantification of Dendrogenin A in Human Tissues.” The Journal of Steroid Biochemistry and Molecular Biology<\/i> 194 (August 12, 2019): 105447. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105447<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Poirot, Marc, Sandrine Silvente-Poirot, and Cholesterol metabolism and therapeutic innovations. “Oxysterols: An Expanding Family of Structurally Diversified Bioactive Steroids.” The Journal of Steroid Biochemistry and Molecular Biology<\/i>, July 31, 2019, 105443. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105443<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Bauriaud-Mallet, Mathilde, Lavinia Vija-Racaru, Séverine Brillouet, Arnaud Mallinger, Philippe de Medina, Arnaud Rives, Bruno Payre, Marc Poirot, Fréderic Courbon, and Sandrine Silvente-Poirot. “The Cholesterol-Derived Metabolite Dendrogenin A Functionally Reprograms Breast Adenocarcinoma and Undifferentiated Thyroid Cancer Cells.” The Journal of Steroid Biochemistry and Molecular Biology<\/i> 192 (June 3, 2019): 105390. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.105390<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Fouache, Allan, Nada Zabaiou, Cyrille De Joussineau, Laurent Morel, Sandrine Silvente-Poirot, Amira Namsi, Gérard Lizard, et al. “Flavonoids Differentially Modulate Liver X Receptors Activity-Structure-Function Relationship Analysis.” The Journal of Steroid Biochemistry and Molecular Biology<\/i> 190 (April 5, 2019): 173–82. https:\/\/doi.org\/10.1016\/j.jsbmb.2019.03.028<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Genovese, Salvatore, Francesco Epifano, Philippe de Medina, Nicolas Caron, Arnaud Rives, Marc Poirot, Sandrine Silvente-Poirot, and Serena Fiorito. “Natural and Semisynthetic Oxyprenylated Aromatic Compounds as Stimulators or Inhibitors of Melanogenesis.” Bioorganic Chemistry<\/i> 87 (March 14, 2019): 181–90. https:\/\/doi.org\/10.1016\/j.bioorg.2019.03.026<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\t\t\t\t
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Taddeo, Vito Alessandro, Francesco Epifano, Francesca Preziuso, Serena Fiorito, Nicolas Caron, Arnaud Rives, Philippe de Medina, Marc Poirot, Sandrine Silvente-Poirot, and Salvatore Genovese. “HPLC Analysis and Skin Whitening Effects of Umbelliprenin-Containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris.” Molecules (Basel, Switzerland)<\/i> 24, no. 3 (January 30, 2019). https:\/\/doi.org\/10.3390\/molecules24030501<\/a>.<\/div>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n\n\n

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LES MEMBRES DE L\u2019\u00c9QUIPE<\/strong><\/h2>\n

[\/et_pb_text][et_pb_divider color=”#F19532″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” max_width=”none” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

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\"\"<\/a><\/div>\n
Lavinia Vija<\/a><\/div>\n
Clinicien Chercheur \/ Researcher hospital practitioner<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Michel Record<\/a><\/div>\n
Chercheur statutaire \/ permanent scientist<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Marc Poirot<\/a><\/div>\n
Chercheur statutaire \/ permanent scientist<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Sandrine Poirot<\/a><\/div>\n
Chercheur statutaire \/ permanent scientist<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Julio Bunay<\/a><\/div>\n
Chercheur Post-Doctorant \/ Post-Doc researcher<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
S\u00e9verine Brillouet<\/a><\/div>\n
Clinicien Chercheur \/ Researcher hospital practitioner<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Philippe De-Medina<\/a><\/div>\n
Ing\u00e9nieur de laboratoire \/ laboratory engineer<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Khadijetou Diallo<\/a><\/div>\n
Doctorant \/ PhD student<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Laly Pucheu<\/a><\/div>\n
Technicien de laboratoire \/ Laboratory Technician<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n
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\"\"<\/a><\/div>\n
Ayadi Silia<\/a><\/div>\n
Doctorant \/ PhD student<\/div><\/div>\n<\/div><\/div><\/div> <\/div>\n <\/div>\n<\/div><\/div>\n\n
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