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Pr Roland Liblau CPTP, Toulouse – Immune checkpoint blockade, neuroinflammation and paraneoplastic neurological disease

13 décembre 2019 @ 11:00 - 12:00

Paraneoplastic neurologic disorders (PND) are immune-mediated neurological diseases that develop in the setting of malignancy. The target onconeural antigens are expressed physiologically by neurons, and aberrantly by certain tumor cells. These tumor-associated antigens can be presented to T cells, generating an antigen-specific immune response that leads to autoimmunity within the nervous system.

In an animal model, in which a neo-self-antigen was expressed in both Purkinje neurons and implanted breast tumor, immune checkpoint blockade led to complete tumor control at the expense of cerebellum infiltration by T cells and Purkinje neuron loss, thereby mimicking PND. Our findings strongly suggest that the production of IFNg by cerebellum-invading T cells plays a major role in Purkinje neuron death. Our successful pre-clinical use of neutralizing anti-IFNg antibody for the treatment of PCD offers a new therapeutic opportunity for cancer patients at the onset of paraneoplastic neurological disorders.

Incidentally, the induction of a cellular immune response within the nervous system through immune checkpoint blockade led us and others to test this approach in the context of chronic JC virus infection in immunocompromised patients.


Date :
13 décembre 2019
Heure :
11:00 - 12:00
Catégorie d’Évènement:


Gilles Favre
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+33(0) 5 82 74 15 75
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+33(0) 5 82 74 15 75
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