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Dr. Fabien JOURDAN / Methods and tools to model cellular metabolism
18 janvier 2019 @ 11:00 - 12:30
Dr. Fabien JOURDAN, INRA Toxalim, Toulouse, France
Metabolic modulation is a cornerstone cellular response to genetic or environmental stresses. In particular, cancerous cells can cope with key genetic mutations by using metabolic bypasses. This plasticity is going beyond central metabolism and may involve complex processes spanning several metabolic pathways. Hence, it is a key challenge to be able to decipher metabolic modulations in a systemic and global perspective.
The aim of the computational methods and tools presented in this seminar is thus to consider the full complexity of metabolism. To do so, all metabolic reactions the cell is able to achieve are gathered in a single mathematical model call “genome scale metabolic network”. Based on this model it is then possible to identify metabolic specificities of different cell lines, predict metabolic behaviours, simulate metabolic responses to single or multiple knock-out and ultimately identify potential drug targets.