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Conférence CRCT : Dr Christopher Pin / University of Western Ontario – Cell stress and epigenetic reprogramming in pancreatic cancer
janvier 24 @ 11:00 - 12:00
Pancreatic cancer is one of the deadliest forms of cancer due to its late diagnosis and resistance to therapy. While genetic factors have been linked to pancreatic cancer, these account for less than 10% of all cases suggesting a significant role for environmental and epigenetic factors in the disease. My laboratory studies signaling pathways activated by adverse environmental factors, including chronic inflammation, and how these pathways may affect pancreatic cancer progression and epigenetic reprogramming. This talk will focus on Activating Transcription Factor 3, a mediator of cell stress, and how this protein affects pancreatic cancer progression. Using pre-clinical models and patient samples, it appears ATF3 affects multiple pathways in pancreatic cancer progression including reprogramming of cell fate through epigenetic mechanisms.