General presentation

Cancer is the consequence of abnormal function of critical genes that drive hallmarks of cancer. At the CRCT we aim at discovering how this process occurs. Several oncogenic molecular mechanism are studied by our teams, including cancer cell signaling, genetic instability, genetic expression, interconnection between cancer cells and the tumour microenvironment, bioenergetics…

We set up research lines to explore the molecular complexity of cancer cells and the tumor diversity by gathering teams studying different aspects of cell transformation. We expect to bring together the pieces of the cancer puzzle and propose a general vision of cancer initiation and progression.

Our basic research is coordinated through 4 lines:

Oncogenic Signaling, DNA Damage Response & Genetic Instability,

RNA and cancer,

Tumor microenvironment and metabolism,


Each line coordinates the interaction between our researchers, in a transversal and collaborative logic between the teams of the Center, in order to understand new molecular mechanisms and to identify new therapeutic strategies.

The benefit we have from the strong interactions between our researchers and our clinicians on the Oncopole site, as well as the excellence of Toulouse’s scientific environment in the fields of physics, chemistry, mathematics and physics, enabled us to set up integrated research programs. With this transdisciplinary approach, our goal is to promote and accelerate the translation from “fundamental” discoveries into the field of clinical applications. To this end, 2 integrated programs have been launched:

mechanisms of resistance and new targets: from molecular to clinical pharmacology,

development of mathematics, physics and computational tools in oncology to explore tumor and patients heterogeneity.


This organization around research lines and integrated programs provides the entire scientific and medical-scientific community of the CRCT and IUCT-O with a stimulating intellectual environment, facilitating the development of new concepts and accelerating the results of research.