CRCT News
Treatment of testicular cancers with high doses of etoposide: impact of the elimination capacities of the drug and the genetic characteristics of the patient on the efficacy and toxicity of the treatment
For patients with refractory or relapsing testicular cancer after standard chemotherapy, more aggressive chemotherapy with carboplatin and etoposide may be used. After this high-dose chemotherapy, a stem cell transplant is performed to replace those that have been...
The 5,6-epoxycholesterol metabolic pathway in breast cancer: emergence of new pharmacological targets
Metabolic pathways have emerged as cornerstones in carcinogenic deregulation providing new therapeutic strategies for cancer management. This is illustrated by the recent discovery of a cholesterol metabolic branch involving the biochemical transformation of...
Different genetic mutations of Kras in pancreatic cancer, different treatments?
Pancreatic cancer is a very poor prognosis. It is caused in more than 80% of cases by oncogenic mutations of the protein called Kras. This mutated Kras protein is active by direct interaction of PI3K proteins. Until now, the subtype of Kras mutation was considered...
A patient gene expression similarity approach leads to new perspectives in disease comorbidity
The fact that many people suffer from more than one disease, known as comorbidity, has become one of the main challenges for the 21st century aging population, as it mainly affects the elderly, decreasing treatment options and patients’ life expectancy while...
Finding gene’s best friends in the social network of blood’s DNA
Some papers including some from our group suggested that the organization of DNA and the genome is like a network. Networks are systems in which many units interact with each other (friends connecting on social media, cities connected by roads, neurons connected in...
Diagnosis of lymphoma on digital histological slides assisted by deep-learning
At a time when e-health is an essential part of modern medicine, virtual slides have become a key element in histopathological diagnosis. Virtual microscopy consists in analyzing high-resolution digitally scanned histology images. The pathologist can observe these...