CRCT News
Reprogram a family of lipids to increase the efficacy of melanoma immunotherapy.
Immunotherapy for advanced melanoma has revolutionized the treatment of this deadly cancer. However, almost half of patients do not respond to this treatment and die within 5 years after starting treatment. Our work shows that melanoma cells exhibit alterations in the...
Rapid detection of a cancer biomarker by a microfluidic chip
Researchers from LAAS-CNRS, in collaboration with the Toulouse Cancer Research Centre, have shown how μLAS microfluidic chip technology can concentrate and measure microRNAs, cancer biomarkers, in less than a minute. MicroRNAs (miRs) are short fragments of RNA that...
The cell signalling enzymes PI3Kalpha and PI3Kβ play major roles in the body.
PI3Ks are important molecules, that, by adding a tag on a lipid, induce messages (also called signals) in the cells. They are hence key regulators of cell signalling. In the animals of higher order, such as Humans, PI3Ks come in different flavours. In particular, the...
A new immunotherapy strategy in melanoma patients.
Melanoma is a bad-prognosis skin cancer generally treated with monoclonal antibodies that neutralize immune checkpoints such as anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab). Unfortunately, a significant proportion of patients do not respond to these treatments....
Interest of DPD deficiency testing in all patients receiving fluoropyrimidines for cancer treatment.
Fluoropyrimidines (including 5-fluorouracil and its prodrug capecitabine) can cause serious adverse events related to a dihydropyrimidine dehydrogenase (DPD) deficiency, the enzyme involved in the degradation of 5-FU. This study reports the case of a patient treated...
Rapid and sensitive detection of biomarkers of interest in cancerology
MicroRNAs are short non-coding RNA sequences whose expression is deregulated in cancers. In particular, miR-21 microRNA is a promising biomarker for the diagnosis and the monitoring of patients with pancreatic cancer. In this work, we use the µLAS microfluidic...