CRCT News
A patient gene expression similarity approach leads to new perspectives in disease comorbidity
The fact that many people suffer from more than one disease, known as comorbidity, has become one of the main challenges for the 21st century aging population, as it mainly affects the elderly, decreasing treatment options and patients’ life expectancy while...
Finding gene’s best friends in the social network of blood’s DNA
Some papers including some from our group suggested that the organization of DNA and the genome is like a network. Networks are systems in which many units interact with each other (friends connecting on social media, cities connected by roads, neurons connected in...
Diagnosis of lymphoma on digital histological slides assisted by deep-learning
At a time when e-health is an essential part of modern medicine, virtual slides have become a key element in histopathological diagnosis. Virtual microscopy consists in analyzing high-resolution digitally scanned histology images. The pathologist can observe these...
A small non-coding RNA molecule controls the presence of three key tumor growth regulators of NPM-ALK(+) T lymphoma.
Lymphoma is a blood cancer which develops from a type of white blood cells present in the lymphatic system; the lymphocytes. There are two types of lymphocytes: B lymphocytes and T lymphocytes. This study focuses on a particular type of blood cancer affecting T...
Supramolecular attack particles are autonomous killing entities released from cytotoxic T-cells
Cytotoxic T cells (CTL) are essential cellular components in the immune response against viruses and cancer. This is why it is essential to better understand the function of these cells and in particular to better understand how these cells manage to kill their target...
Role of sphingosin kinase 1 in cancer immunotherapy
Immunotherapy is a treatment that aims to educate our immune system against cancer cells. This treatment resulted in a long-term response in patients with metastatic melanoma (40-60%) with in some cases total tumour regression. The challenge is now that the maximum...