CRCT News
Targeted therapies against cancer cells – How to overcome adaptive response defence mechanisms of cancer cells ?
What signals do cancer cells send to prevent these therapies from working? A targeted therapy is a therapy that prevents a specifically active signal in tumour cells. Our team is interested in inhibitors of PI3Ks, innovative targeted therapies for solid and liquid...
GAMMORA : a tool to automatically prepare rardiation therapy simulation
The radiation dose delivered to the patient in radiotherapy is usually calculated using commercial software ("TPS") which allows a very accurate calculation in the vast majority of clinical cases. However, it is sometimes necessary to have access to a reference...
Overexpression of the oncogenic long noncoding RNA LONA in acute myeloid leukemia and change in its cellular location by the mutant protein NPM1c+.
In this study, we describe the oncogenic role of a novel long noncoding RNA (lncRNA) called LONA (LncRNA Overexpressed in NPM1 mutated Acute myeloid leukemia) overexpressed in patients with acute myeloid leukemia (AML) carrying the mutation of the nucleophosmin NPM1....
PI3K proteins sense mechanical forces in tumours.
A tumour cell experiences mechanical forces of compression, traction and shear. These physical forces induce a signal in the cancer cell. The transmission of this signal is very fast and involves deformation of the cell. A huge current research effort is aimed at...
A study of the interplay effect in radiation therapy using a Monte-Carlo model.
Radiation therapy must take into account tumor motion. Indeed, during the treatment the target can move up to several centimeters. This could lead to an under dosage of the target or an over dosage of the Organs at Risk (OARs). For classic treamtment the motion is...
The rapid progression and poor prognosis of pancreatic cancer: a therapeutic lead.
Pancreatic cancer is a disease with a poor prognosis that progresses very rapidly after detection to metastatic spread. At detection, the primary tumour may be associated with a so-called micro-metastatic disease which, because it is microscopic, goes unnoticed with...