by Stephane Cailmail | 4 Jan 2021 | General news, Publications, Research
Trabectedin is a cytotoxic drug used for the treatment of advanced soft tissue sarcoma. One of the most frequent side effects is hepatotoxicity, which occurs in nearly 40% of patients. In this pharmacogenetic study, we aimed to identify genetic polymorphisms that...
by Stephane Cailmail | 9 Nov 2020 | General news, Publications, Research
The ALK oncogene (Anaplastic Lymphoma Kinase) is a constitutively active tyrosine kinase involved in an increasing number of cancers. Initially identified as being responsible for the majority of pediatric anaplastic large cell lymphomas, its involvement in a wider...
by Stephane Cailmail | 6 Nov 2020 | General news, Publications, Research
Anaplastic large cell lymphoma is one of the most common pediatric T-lymphomas. It mainly affects CD4 lymphocytes (major guardian of the immune system) and is associated in more than 80% of cases with the NPM-ALK chromosomal translocation (which is the transfer of...
by Stephane Cailmail | 4 Nov 2020 | General news, Publications, Research
Plasma concentrations of endoxifen, the main active metabolite of tamoxifen, show large differences between individuals due to genetic and demographic factors as well as concomitant treatments. This study evaluates the impact of genetic differences and other...
by Stephane Cailmail | 20 Oct 2020 | General news, Publications, Research
The work presented in this article is based on a clinical observation: 3 children from the same family all suffered from B-acute lymphoblastic leukemia (B-ALL). Knowing that it is a very rare disease, we suspected a genetic predisposition and by reading the genome of...
by Stephane Cailmail | 16 Oct 2020 | General news, Publications, Research
Radiotherapy is one of the therapeutic weapons with the surgery of local cancer treatment. Radiation therapy involves exposing part of the body to ionizing radiation. The principle of ionizing radiation is to deliver a certain amount of energy, the importance of which...
