CRCT - Centre de Recherches en Cancérologie de Toulouse
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Genetic polymorphisms involved in trabectedin-related liver toxicity.

Genetic polymorphisms involved in trabectedin-related liver toxicity.

by Stephane Cailmail | 4 Jan 2021 | General news, Publications, Research

Trabectedin is a cytotoxic drug used for the treatment of advanced soft tissue sarcoma. One of the most frequent side effects is hepatotoxicity, which occurs in nearly 40% of patients. In this pharmacogenetic study, we aimed to identify genetic polymorphisms that...
New combined therapy to promote self-digestion and death of lymphoma cells expressing the ALK oncogene

New combined therapy to promote self-digestion and death of lymphoma cells expressing the ALK oncogene

by Stephane Cailmail | 9 Nov 2020 | General news, Publications, Research

The ALK oncogene (Anaplastic Lymphoma Kinase) is a constitutively active tyrosine kinase involved in an increasing number of cancers. Initially identified as being responsible for the majority of pediatric anaplastic large cell lymphomas, its involvement in a wider...
T-lymphocytes transformed in the laboratory help to better understand the origin of a child’s lymphoma.

T-lymphocytes transformed in the laboratory help to better understand the origin of a child’s lymphoma.

by Stephane Cailmail | 6 Nov 2020 | General news, Publications, Research

Anaplastic large cell lymphoma is one of the most common pediatric T-lymphomas. It mainly affects CD4 lymphocytes (major guardian of the immune system)  and is associated in more than 80% of cases with the NPM-ALK chromosomal translocation (which is the transfer of...
How much does genetics and other medications impact the effect of tamoxifen treatment in breast cancer ?

How much does genetics and other medications impact the effect of tamoxifen treatment in breast cancer ?

by Stephane Cailmail | 4 Nov 2020 | General news, Publications, Research

Plasma concentrations of endoxifen, the main active metabolite of tamoxifen, show large differences between individuals due to genetic and demographic factors as well as concomitant treatments. This study evaluates the impact of genetic differences and other...
Identification of a new mutation that predisposes to leukemia

Identification of a new mutation that predisposes to leukemia

by Stephane Cailmail | 20 Oct 2020 | General news, Publications, Research

The work presented in this article is based on a clinical observation: 3 children from the same family all suffered from B-acute lymphoblastic leukemia (B-ALL). Knowing that it is a very rare disease, we suspected a genetic predisposition and by reading the genome of...
Dosimetric performance of continuous EPID imaging in stereotactic treatment conditions

Dosimetric performance of continuous EPID imaging in stereotactic treatment conditions

by Stephane Cailmail | 16 Oct 2020 | General news, Publications, Research

Radiotherapy is one of the therapeutic weapons with the surgery of local cancer treatment. Radiation therapy involves exposing part of the body to ionizing radiation. The principle of ionizing radiation is to deliver a certain amount of energy, the importance of which...
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News

  • Genetic polymorphisms involved in trabectedin-related liver toxicity.
  • Cancer: a key mechanism of resistance to immunotherapy identified
  • Audrey Lumeau (team 10) awarded at “the 5th AEK Autumn School” of AEK 2020
  • Congratulation to Benoît Thibault, Axis 1 poster prize during the 16th Cancéropôle GSO Days
  • Salvatore Valitutti, director of research at the Inserm Cancer Research Centre in Toulouse obtains an ERC Synergy, prestigious European funding
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