by Stephane Cailmail | 15 May 2020 | Actualités générales, Publications, Research
Lymphoma is a blood cancer which develops from a type of white blood cells present in the lymphatic system; the lymphocytes. There are two types of lymphocytes: B lymphocytes and T lymphocytes. This study focuses on a particular type of blood cancer affecting T...
by Stephane Cailmail | 11 May 2020 | Actualités générales, Publications, Research
Cytotoxic T cells (CTL) are essential cellular components in the immune response against viruses and cancer. This is why it is essential to better understand the function of these cells and in particular to better understand how these cells manage to kill their target...
by Stephane Cailmail | 7 Feb 2020 | Actualités générales, General news, Publications, Research
Immunotherapy is a treatment that aims to educate our immune system against cancer cells. This treatment resulted in a long-term response in patients with metastatic melanoma (40-60%) with in some cases total tumour regression. The challenge is now that the maximum...
by Stephane Cailmail | 7 Feb 2020 | Actualités générales, Publications
Dendrogenin A (DDA) is a tumor suppressor mammalian cholesterol-derived metabolite and a new class of ligand of the Liver X receptor (LXR), which displays tumor cell differentiation. In human and mouse breast adenocarcinoma cells, DDA-induced cell differentiation was...
![Focus: Anti-TNF[alpha] antibodies improve immunotherapy in melanoma](https://www.crct-inserm.fr/wp-content/uploads/2018/03/Segui_Meyer_2.jpg)
by Sébastien Guibert | 16 Mar 2018 | Actualités générales
Melanoma is a poor-prognosis skin cancer. Immunotherapy based on the use of monoclonal antibodies (anti-CTLA-4 and anti-PD-1) activates the immune system to fight melanoma and has improved the prognosis of this cancer. Those antibodies block checkpoints, which act as...
by Sébastien Guibert | 11 Dec 2017 | Actualités générales
A 2-years post-doctoral position is open in CRCT’s team 19 (ONCOSARC / F. Chibon), starting 01/01/2018 Description The ONCOSARC team of CRCT is focused on deciphering pleomorphic sarcoma oncogenesis. Since these tumors are characterized by a highly rearranged...
