ALKATRAS : Role and regulation of autophagy in ALK dependent tumours

Autophagy is an emerging cancer research field. Depending on the tumor context, it can harbor pro-survival or pro-death functions. Studying its status, role and regulation (in particular post-transcriptional regulation through microRNA and/or RNA-Binding proteins) in different ALK primary tumors and cell lines is the focus of this ESR project.

We specifically aim to: determine the role of autophagy, using classical autophagy assays, in ALCL, NSCLC and neuroblastoma cell lines and mouse models; test whether autophagy modulation can potentiate the efficacy of ALK therapies (targeted-, chemo- and immuno-therapies); investigate the regulation of autophagy by miRNAs and RNA-BPs or epigenetic modifications.

CRCT Partner  : Sylvie Giuriato, Domenico Sorrentino

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Start date : 01 septembre 2015
End date : 31 août 2019

This research programme is part of the European Horizon 2020 Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) call for proposals : https://www.horizon2020.gouv.fr/cid144802/appel-2020-innovative-training-networks-itn.html

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