M. Bardiès

  Multiscale dosimetry for radiotherapy optimization

 

 

 

 

 

 

 

Our research project at a glance

 

Radiotherapy efficacy relies on treatment personalisation: Irradiation must be elevated in tumour targets, whereas healthy/critical organs/tissues irradiation must be minimized.

Our team works at optimizing several forms of radiotherapy, by measuring or modelling radiation transport at various scales, from cell to patient.

 

Objectives

 

Targeted RadioTherapy (TRT) is a cancer therapy based on the administration of radiolabelled selective vectors. Currently, administration is based on fixed activities, eventually modulated by patient mass or body surface area. This approach disregards pharmacokinetics inter-patient variability, and does not benefit from the possibility to perform a patient-specific assessment of delivered irradiation.

Our objective is to implement a paradigm shift from “radioactive chemotherapy” towards “systemic radiotherapy”, where each patient benefits from a personalised treatment.

With this aim, our team develops innovative dosimetric approaches at all scales (cell, tissue, patient) by quantifying activity distributions (quantitative imaging) and modelling radiation transport for various emitters (alpha, beta, Auger) used for TRT.

These developments in radiation transport modelling are progressively extended to preclinical and clinical external beam radiotherapy, mainly in a context of complex irradiation or/and small irradiation beams.

 

Key words

 

  • Dosimetry
  • Monte Carlo modelling

 

Labels and networks

 

  • Network OpenGate
  • Networks Geant4 and Geant4-DNA
  • Network EFOMP (European Federation of Organisations for Medical Physics)
  • Network EANM (European Association of Nuclear Medicine)
  • Network AIEA (International Agency of Atomic Energy)
  • Network EURAMET (European Association of National Metrology Institutes)

 

Selected publications


2017

Beilla, S; Younes, T; Vieillevigne, L; Bardies, M; Franceries, X; Simon, L

Monte Carlo dose calculation in presence of low-density media: Application to lung SBRT treated during DIBH Journal Article

Phys Med, 41 , pp. 46-52, 2017, ISSN: 1724-191X (Electronic) 1120-1797 (Linking).

Links | BibTeX

Bordes, J; Incerti, S; Lampe, N; Bardies, M; Bordage, M C

Low-energy electron dose-point kernel simulations using new physics models implemented in Geant4-DNA Journal Article

Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, 398 , pp. 13-20, 2017, ISSN: 0168-583x.

Links | BibTeX

Villoing, D; Marcatili, S; Garcia, M P; Bardies, M

Internal dosimetry with the Monte Carlo code GATE: validation using the ICRP/ICRU female reference computational model Journal Article

Phys Med Biol, 62 (5), pp. 1885-1904, 2017, ISSN: 1361-6560 (Electronic) 0031-9155 (Linking).

Links | BibTeX

2016

Arnaud, F X; Paillas, S; Pouget, J P; Incerti, S; Bardies, M; Bordage, M C

Complex cell geometry and sources distribution model for Monte Carlo single cell dosimetry with iodine 125 radioimmunotherapy Journal Article

Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms, 366 , pp. 227-233, 2016, ISSN: 0168-583x.

Links | BibTeX

Marcatili, S; Pichard, A; Courteau, A; Ladjohounlou, R; Navarro-Teulon, I; Repetto-Llamazares, A; Heyerdahl, H; Dahle, J; Pouget, J P; Bardies, M

Realistic multi-cellular dosimetry for 177Lu-labelled antibodies: model and application Journal Article

Phys Med Biol, 61 (19), pp. 6935-6952, 2016, ISSN: 1361-6560 (Electronic) 0031-9155 (Linking).

Links | BibTeX

2014

Flux, G D; Bardies, M; Lassmann, M

Biting the magic bullet: celebrating a decade of the EANM Dosimetry Committee Journal Article

Eur J Nucl Med Mol Imaging, 41 (1), pp. 1-3, 2014, ISSN: 1619-7089 (Electronic) 1619-7070 (Linking).

Links | BibTeX

Marcatili, S; Villoing, D; Garcia, M P; Bardies, M

Multi-scale hybrid models for radiopharmaceutical dosimetry with Geant4 Journal Article

Phys Med Biol, 59 (24), pp. 7625-41, 2014, ISSN: 1361-6560 (Electronic) 0031-9155 (Linking).

Links | BibTeX

Sarrut, D; Bardies, M; Boussion, N; Freud, N; Jan, S; Letang, J M; Loudos, G; Maigne, L; Marcatili, S; Mauxion, T; Papadimitroulas, P; Perrot, Y; Pietrzyk, U; Robert, C; Schaart, D R; Visvikis, D; Buvat, I

A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications Journal Article

Med Phys, 41 (6), pp. 064301, 2014, ISSN: 2473-4209 (Electronic) 0094-2405 (Linking).

Links | BibTeX

2013

Mauxion, T; Barbet, J; Suhard, J; Pouget, J P; Poirot, M; Bardies, M

Improved realism of hybrid mouse models may not be sufficient to generate reference dosimetric data Journal Article

Med Phys, 40 (5), pp. 052501, 2013, ISSN: 2473-4209 (Electronic) 0094-2405 (Linking).

Links | BibTeX

2012

Ferrer, L; Malek, E; Bodet-Milin, C; Legouill, S; Prangere, T; Robu, D; Jeans, S; Tipping, J; Huglo, D; Carpentier, P; Illidge, T; Kraeber-Bodere, F; Morschhauser, F; Bardies, M

Comparisons of dosimetric approaches for fractionated radioimmunotherapy of non-Hodgkin lymphoma Journal Article

Q J Nucl Med Mol Imaging, 56 (6), pp. 529-37, 2012, ISSN: 1824-4785 (Print) 1824-4785 (Linking).

Links | BibTeX