H. Avet-Loiseau / L. Martinet

  Oncogenomics and immunology of myeloma

 

 

 

 

 

 

Our research project at a glance

 

Our team is entirely focused on multiple myeloma (MM), a cancer of the bone marrow.

We develop three main axes:

  • massive sequencing of tumors to understand how molecular abnormalities impact patient survival,
  • analysis of the immune system of these patients in order to try to activate it to eliminate the tumor cells,
  • analysis of the interactions between tumor cells and the medullary microenvironment.

 

Objectives

 

Our objective is mainly translational, that is to try to improve the therapeutic management of the patients in order to prolong their survival. To achieve this, we have created a national network that has enabled to build the world’s largest tumor bank, linked to a computer database that brings together the clinical and evolutionary characteristics of these thousands of patients.

Our first axis aims at sequencing the genome of these tumors with the aim of identifying subgroups of patients who would be better able to respond to specific treatments in order to help clinicians in their therapeutic choices. In the same vein, we have developed a technique for quantifying minimal residual disease in patients in complete response, in order to adapt the treatment to the residual tumor mass.

The second axis aims to better characterize the immune system of patients with MM, with a dual objective:

  • to understand the causes of immunodepression of patients by characterizing the different immune compartments,
  • and to propose therapeutic approaches based on monoclonal antibodies targeting immune cells.

Our third objective is to better understand the interactions between tumor cells and other normal bone marrow cells, which contribute largely to the clinical expression of the disease, mainly bone fractures.

We focus our research on mesenchymal stem cells.

 

Key words

 

  • Multiple Myeloma
  • Pharmacogenomics
  • Immunology
  • Microenvironment
  • NGS

 

Selected publications


2017

Harousseau, J L; Avet-Loiseau, H

Minimal Residual Disease Negativity Is a New End Point of Myeloma Therapy Journal Article

J Clin Oncol, 35 (25), pp. 2863-2865, 2017, ISSN: 1527-7755 (Electronic) 0732-183X (Linking).

Links | BibTeX

Robiou du Pont, S; Cleynen, A; Fontan, C; Attal, M; Munshi, N; Corre, J; Avet-Loiseau, H

Genomics of Multiple Myeloma Journal Article

J Clin Oncol, 35 (9), pp. 963-967, 2017, ISSN: 1527-7755 (Electronic) 0732-183X (Linking).

Links | BibTeX

2016

Avet-Loiseau, H; Fonseca, R; Siegel, D; Dimopoulos, M A; Spicka, I; Masszi, T; Hajek, R; Rosinol, L; Goranova-Marinova, V; Mihaylov, G; Maisnar, V; Mateos, M V; Wang, M; Niesvizky, R; Oriol, A; Jakubowiak, A; Minarik, J; Palumbo, A; Bensinger, W; Kukreti, V; Ben-Yehuda, D; Stewart, A K; Obreja, M; Moreau, P

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma Journal Article

Blood, 128 (9), pp. 1174-80, 2016, ISSN: 1528-0020 (Electronic) 0006-4971 (Linking).

Links | BibTeX

2015

Guillerey, C; Ferrari de Andrade, L; Vuckovic, S; Miles, K; Ngiow, S F; Yong, M C; Teng, M W; Colonna, M; Ritchie, D S; Chesi, M; Bergsagel, P L; Hill, G R; Smyth, M J; Martinet, L

Immunosurveillance and therapy of multiple myeloma are CD226 dependent Journal Article

J Clin Invest, 125 (5), pp. 2077-89, 2015, ISSN: 1558-8238 (Electronic) 0021-9738 (Linking).

Links | BibTeX

Hebraud, B; Magrangeas, F; Cleynen, A; Lauwers-Cances, V; Chretien, M L; Hulin, C; Leleu, X; Yon, E; Marit, G; Karlin, L; Roussel, M; Stoppa, A M; Belhadj, K; Voillat, L; Garderet, L; Macro, M; Caillot, D; Mohty, M; Facon, T; Moreau, P; Attal, M; Munshi, N; Corre, J; Minvielle, S; Avet-Loiseau, H

Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in multiple myeloma: the IFM experience Journal Article

Blood, 125 (13), pp. 2095-100, 2015, ISSN: 1528-0020 (Electronic) 0006-4971 (Linking).

Links | BibTeX

Martinet, L; Ferrari De Andrade, L; Guillerey, C; Lee, J S; Liu, J; Souza-Fonseca-Guimaraes, F; Hutchinson, D S; Kolesnik, T B; Nicholson, S E; Huntington, N D; Smyth, M J

DNAM-1 expression marks an alternative program of NK cell maturation Journal Article

Cell Rep, 11 (1), pp. 85-97, 2015, ISSN: 2211-1247 (Electronic).

Links | BibTeX

Martinet, L; Smyth, M J

Balancing natural killer cell activation through paired receptors Journal Article

Nat Rev Immunol, 15 (4), pp. 243-54, 2015, ISSN: 1474-1741 (Electronic) 1474-1733 (Linking).

Links | BibTeX

2014

Bolli, N; Avet-Loiseau, H; Wedge, D C; Van Loo, P; Alexandrov, L B; Martincorena, I; Dawson, K J; Iorio, F; Nik-Zainal, S; Bignell, G R; Hinton, J W; Li, Y; Tubio, J M; McLaren, S; S, Meara O'; Butler, A P; Teague, J W; Mudie, L; Anderson, E; Rashid, N; Tai, Y T; Shammas, M A; Sperling, A S; Fulciniti, M; Richardson, P G; Parmigiani, G; Magrangeas, F; Minvielle, S; Moreau, P; Attal, M; Facon, T; Futreal, P A; Anderson, K C; Campbell, P J; Munshi, N C

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma Journal Article

Nat Commun, 5 , pp. 2997, 2014, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

Links | BibTeX

Chan, C J; Martinet, L; Gilfillan, S; Souza-Fonseca-Guimaraes, F; Chow, M T; Town, L; Ritchie, D S; Colonna, M; Andrews, D M; Smyth, M J

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions Journal Article

Nat Immunol, 15 (5), pp. 431-8, 2014, ISSN: 1529-2916 (Electronic) 1529-2908 (Linking).

Links | BibTeX

2013

Avet-Loiseau, H; Hulin, C; Campion, L; Rodon, P; Marit, G; Attal, M; Royer, B; Dib, M; Voillat, L; Bouscary, D; Caillot, D; Wetterwald, M; Pegourie, B; Lepeu, G; Corront, B; Karlin, L; Stoppa, A M; Fuzibet, J G; Delbrel, X; Guilhot, F; Kolb, B; Decaux, O; Lamy, T; Garderet, L; Allangba, O; Lifermann, F; Anglaret, B; Moreau, P; Harousseau, J L; Facon, T

Chromosomal abnormalities are major prognostic factors in elderly patients with multiple myeloma: the intergroupe francophone du myelome experience Journal Article

J Clin Oncol, 31 (22), pp. 2806-9, 2013, ISSN: 1527-7755 (Electronic) 0732-183X (Linking).

Links | BibTeX