J.J. Fournié

  Therapeutic Innovations in B lymphomas

 

 

 

 

 

 

 

Our research project at a glance

 

Non-Hodgkin B cell lymphoma (NHL) including chronic lymphocytic leukemia (CLL) are increasingly frequent hematopoietic malignancies. The patients care relies on chemotherapies, immunotherapies and radiotherapy combinations, but relapse and/or unresponsiveness are far too frequent. So our team aims at improving the efficacy of treatments for NHL, notably by assessing immune checkpoint blockade (ICB) in this context.

 

Objectives

 

More specifically, we develop novel tools including analytic methods and biological models to find new molecular pathways for targeting NHL by novel drugs, and assess them in preclinical models, prior to translate our most promising new approaches in Phase l/ll clinical trials of IUC-Toulouse Oncopole.

This includes :

  • predicting response of patients to treatment (ibrutinib in CLL, ICB in NHL),
  • harnessing innate immunity against lymphoma models,
  • development of a humanized anti-TAM mAb neutralizing the stromal support of NHL.

 

Key words

 

  • Lymphoma
  • MALC models
  • Datamining
  • Bioinformatics
  • Deep learning
  • RNAseq
  • Therapy
  • Drugs
  • Immune checkpoints
  • Flow cytometry

 

Selected publications


2017

Boissard, F; Tosolini, M; Ligat, L; Quillet-Mary, A; Lopez, F; Fournie, J J; Ysebaert, L; Poupot, M

Nurse-like cells promote CLL survival through LFA-3/CD2 interactions Journal Article

Oncotarget, 8 (32), pp. 52225-52236, 2017, ISSN: 1949-2553 (Electronic) 1949-2553 (Linking).

Links | BibTeX

2016

Betrian, S; Ysebaert, L; Heider, K H; Delord, J P; Fournie, J J; Quillet-Mary, A

Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment Journal Article

Blood Cancer J, 6 (11), pp. e496, 2016, ISSN: 2044-5385 (Electronic) 2044-5385 (Linking).

Links | BibTeX

Boissard, F; Laurent, C; Ramsay, A G; Quillet-Mary, A; Fournie, J J; Poupot, M; Ysebaert, L

Nurse-like cells impact on disease progression in chronic lymphocytic leukemia Journal Article

Blood Cancer J, 6 , pp. e381, 2016, ISSN: 2044-5385 (Electronic) 2044-5385 (Linking).

Links | BibTeX

Duault, C; Franchini, D M; Familliades, J; Cayrol, C; Roga, S; Girard, J P; Fournie, J J; Poupot, M

TCRVgamma9 gammadelta T Cell Response to IL-33: A CD4 T Cell-Dependent Mechanism Journal Article

J Immunol, 196 (1), pp. 493-502, 2016, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

Links | BibTeX

Guggino, G; Ciccia, F; Di Liberto, D; Lo Pizzo, M; Ruscitti, P; Cipriani, P; Ferrante, A; Sireci, G; Dieli, F; Fournie, J J; Giacomelli, R; Triolo, G

Interleukin (IL)-9/IL-9R axis drives gammadelta T cells activation in psoriatic arthritis patients Journal Article

Clin Exp Immunol, 186 (3), pp. 277-283, 2016, ISSN: 1365-2249 (Electronic) 0009-9104 (Linking).

Links | BibTeX

Poupot, M; Turrin, C O; Caminade, A M; Fournie, J J; Attal, M; Poupot, R; Fruchon, S

Poly(phosphorhydrazone) dendrimers: yin and yang of monocyte activation for human NK cell amplification applied to immunotherapy against multiple myeloma Journal Article

Nanomedicine, 12 (8), pp. 2321-2330, 2016, ISSN: 1549-9642 (Electronic) 1549-9634 (Linking).

Links | BibTeX

Tosolini, M; Algans, C; Pont, F; Ycart, B; Fournie, J J

Large-scale microarray profiling reveals four stages of immune escape in non-Hodgkin lymphomas Journal Article

Oncoimmunology, 5 (7), pp. e1188246, 2016, ISSN: 2162-4011 (Print) 2162-4011 (Linking).

Links | BibTeX

2015

Lafouresse, F; Bellard, E; Laurent, C; Moussion, C; Fournie, J J; Ysebaert, L; Girard, J P

L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo Journal Article

Blood, 126 (11), pp. 1336-45, 2015, ISSN: 1528-0020 (Electronic) 0006-4971 (Linking).

Links | BibTeX