J.J. Fournié

  Therapeutic Innovations in B lymphomas

 

 

 

 

 

 

 

Our research project at a glance

Non-Hodgkin B cell lymphoma (NHL) including chronic lymphocytic leukemia (CLL) are increasingly frequent hematopoietic malignancies. Their treatment relies on chemotherapies, immunotherapies and radiotherapeutic combinations, but relapse and/or unresponsiveness are far too frequent. So our team aims at improving the efficacy of such treatments, notably by assessing newer immune checkpoint blockers (ICB) in this context.

Last update december 2019

 

 

Objectives

More specifically, we develop novel tools including analytic methods and biological models to find new molecular pathways for targeting NHL by novel drugs, and assess these in preclinical models, prior to translate the most promising ones in Phase l/ll clinical trials of IUC-Toulouse Oncopole.

This includes :

  • predicting response of patients to treatment (ibrutinib in CLL, ICB in NHL, CAR-T cells in DLBCL),
  • harnessing innate immunity against lymphoma models,
  • development of a humanized anti-TAM mAb neutralizing the stromal support of NHL.

Last update december 2019

Key words
  • Lymphoma
  • MALC models
  • OncoImmunology
  • Datamining
  • Bioinformatics
  • Single cell RNAseq
  • Therapy
  • Immune checkpoints
  • Flow cytometry

Last update december 2019

 

Labels and networks

 

Last update december 2019

Selected publications


2019

Pont, F; Tosolini, M; Fournié, JJ.

Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets. Journal Article

Nucleic Acids Res, 47 (21), pp. e133, 2019.

Abstract | Links | BibTeX

Curdy, N; Lanvin, O; Laurent, C; Fournié, JJ. ; DM., Franchini

Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptors Expression. Journal Article

Trends Cell Biol, 29 (10), pp. 777-790, 2019.

Abstract | Links | BibTeX

Laplagne, C; Domagala, M; Le-Naour, A; Quemerais, C; Hamel, D; Fournié, JJ. ; Couderc, B; Bousquet, C; Ferrand, A; Poupot, M

Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression. Journal Article

Int J Mol Sci, 20 (19), pp. E4719, 2019.

Abstract | Links | BibTeX

Decaup, E; Rossi, C; Gravelle, P; Laurent, C; Bordenave, J; Tosolini, M; Tourette, A; Perrial, E; Dumontet, C; Poupot, M; Klein, C; Savina, A; Fournié, JJ. ; Bezombes, C

A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma. Journal Article

Front Immunol, (10), pp. 1943, 2019.

Abstract | Links | BibTeX

Franchini, DM. ; Lanvin, O; Curdy, N; JJ., Fournié

Control of lymphocyte activity by stress granules. New targets for immunotherapy ? Journal Article

Med Sci, 35 (6-7), pp. 507-509, 2019.

Links | BibTeX

Pizzolato, G; Kaminski, H; Tosolini, M; Franchini, DM. ; Pont, F; Martins, F; Valle, C; Labourdette, D; Cadot, S; Quillet-Mary, A; Poupot, M; Laurent, C; Ysebaert, L; Meraviglia, S; Dieli, F; Merville, P; Milpied, P; Déchanet-Merville, J; Fournié, JJ.

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes. Journal Article

Proc natl Acad Sci USA, 116 (24), pp. 11906-11915, 2019.

Abstract | Links | BibTeX

Franchini, DM. ; Lanvin, O; Tosolini, M; Patras de, Campaigno E; Cammas, A; Péricart, S; Scarlata, CM. ; Lebras, M; Rossi, C; Ligat, L; Pont, F; Arimondo, PB. ; Laurent, C; Ayyoub, M; Despas, F; Lapeyre-Mestre, M; Millevoi, S; Fournié, JJ.

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells. Journal Article

Cell rep, 26 (1), pp. 94-107, 2019.

Abstract | Links | BibTeX

2018

Rossi, C; Gravelle, P; Decaup, E; Bordenave, J; Poupot, M; Tosolini, M1; Franchini, DM. ; Laurent, C; Morin, R; Lagarde, JM. ; Ysebaert, L; Ligat, L; Jean, C; Savina, A; Klein, C; Céspedes, AM. ; Perez-Galan, P; Fournié, JJ. ; Bezombes, C

Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 blockade in follicular lymphoma. Journal Article

Oncoimmunology, 8 (3), pp. 1554175, 2018.

Abstract | Links | BibTeX

Péricart, S; Tosolini, M; Gravelle, P; Rossi, C; Traverse-Glehen, A; Amara, N; Franchet, C; Martin, E; Bezombes, C; Laurent, G; Brousset, P; Fournié, JJ. ; Laurent, C

Profiling Immune Escape in Hodgkin's and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining. Journal Article

Cancer (Basel), 10 (11), pp. 415, 2018.

Abstract | Links | BibTeX

2017

Tosolini, M; Pont, F; Poupot, M; Vergez, F; Nicolau-Travers, ML. ; Vermijlen, D; Sarry, JE. ; Dieli, F; Fournié, JJ.

Assessment of tumor-infiltrating TCRVγ9Vδ2 γδ lymphocyte abundance by deconvolution of human cancers microarrays. Journal Article

Oncoimmunology, 6 (3), pp. e1284723, 2017.

Abstract | Links | BibTeX

Boissard, F; Tosolini, M; Ligat, L; Quillet-Mary, A; Lopez, F; Fournie, J J; Ysebaert, L; Poupot, M

Nurse-like cells promote CLL survival through LFA-3/CD2 interactions Journal Article

Oncotarget, 8 (32), pp. 52225-52236, 2017, ISSN: 1949-2553 (Electronic) 1949-2553 (Linking).

Links | BibTeX

2016

Betrian, S; Ysebaert, L; Heider, K H; Delord, J P; Fournie, J J; Quillet-Mary, A

Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment Journal Article

Blood Cancer J, 6 (11), pp. e496, 2016, ISSN: 2044-5385 (Electronic) 2044-5385 (Linking).

Links | BibTeX

Boissard, F; Laurent, C; Ramsay, A G; Quillet-Mary, A; Fournie, J J; Poupot, M; Ysebaert, L

Nurse-like cells impact on disease progression in chronic lymphocytic leukemia Journal Article

Blood Cancer J, 6 , pp. e381, 2016, ISSN: 2044-5385 (Electronic) 2044-5385 (Linking).

Links | BibTeX

Duault, C; Franchini, D M; Familliades, J; Cayrol, C; Roga, S; Girard, J P; Fournie, J J; Poupot, M

TCRVgamma9 gammadelta T Cell Response to IL-33: A CD4 T Cell-Dependent Mechanism Journal Article

J Immunol, 196 (1), pp. 493-502, 2016, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

Links | BibTeX

Guggino, G; Ciccia, F; Di Liberto, D; Lo Pizzo, M; Ruscitti, P; Cipriani, P; Ferrante, A; Sireci, G; Dieli, F; Fournie, J J; Giacomelli, R; Triolo, G

Interleukin (IL)-9/IL-9R axis drives gammadelta T cells activation in psoriatic arthritis patients Journal Article

Clin Exp Immunol, 186 (3), pp. 277-283, 2016, ISSN: 1365-2249 (Electronic) 0009-9104 (Linking).

Links | BibTeX

Poupot, M; Turrin, C O; Caminade, A M; Fournie, J J; Attal, M; Poupot, R; Fruchon, S

Poly(phosphorhydrazone) dendrimers: yin and yang of monocyte activation for human NK cell amplification applied to immunotherapy against multiple myeloma Journal Article

Nanomedicine, 12 (8), pp. 2321-2330, 2016, ISSN: 1549-9642 (Electronic) 1549-9634 (Linking).

Links | BibTeX

Tosolini, M; Algans, C; Pont, F; Ycart, B; Fournie, J J

Large-scale microarray profiling reveals four stages of immune escape in non-Hodgkin lymphomas Journal Article

Oncoimmunology, 5 (7), pp. e1188246, 2016, ISSN: 2162-4011 (Print) 2162-4011 (Linking).

Links | BibTeX

2015

Lafouresse, F; Bellard, E; Laurent, C; Moussion, C; Fournie, J J; Ysebaert, L; Girard, J P

L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo Journal Article

Blood, 126 (11), pp. 1336-45, 2015, ISSN: 1528-0020 (Electronic) 0006-4971 (Linking).

Links | BibTeX