Our research project at a glance
Non coding RNA (ncRNA) are RNA without protein-coding potential. Despite intensive research on ncRNA, our overall knowledge of ncRNA function in carcinogenesis remains very limited. One of the main challenges of our team in understanding the function of a specific non-coding RNA such as long and micro ncRNA in cancer, is deciphering their interactome (other RNAs, specific protein complexes, regions of DNA…), and regulations.
In the last decade, it has become increasingly clear that post-transcriptional control of gene expression plays an essential role in tumor cell dysregulation. Studies at the RNA level have been focused for a long time on mRNA, the best known RNA family that represents only a small part of transcripts (2 to 5% of total RNAs). However, the human genome contains much more than just protein-coding genes and the majority of transcribed RNAs are non-coding (ncRNA) such as microRNAs (miRNA), long non-coding RNAs (lncRNA), interfering RNAs, piwiRNAs, or small nucleolar RNAs (snoRNA). Evidence is accumulating that these ncRNAs play key roles in regulating numerous pathways involved in cancer development and progression.
The lab explores the expression profiles and functions of microRNAs and lncRNAs in hematological malignancies, their interaction with proteins and their protein coding potential (with a focus on primary miRNA transcripts, pri-miR). Two types of tumors for which our team has an international expertise or represent cancers with potential of resistance are investigated: T-cell lymphoma including anaplastic large cell lymphoma and acute myeloid leukemia.
Our objectives are:
- to decipher how ncRNAs dysregulation in leukemias/lymphomas could impact on their prognosis (relapse, response and resistance to treatment) and ideally to identify prognostic biomarkers.
- to investigate the role of ER stress on ncRNAs expression in leukemia and their impact on tumor progression and response to treatment.
- to study the physiological and pathological role of these ncRNA including the identification of their downstream target genes, whose role in classical (proliferation, survival, invasion) pathways of cancerogenesis will be functionally characterized.
- to study the upstream mechanisms of ncRNA regulation (epigenetic control of their expression, control of their expression by microRNA encoded peptites (miPEPs), control of their stability by specific endoribonucleases).
- Acute myeloid leukemia
- Anaplastic large cell lymphoma
- Target therapy
- ER stress
Labels and networks
Grants and funders
- Ligue Nationale Contre le Cancer
- Agence Nationale de la Recherche
- Fondation ARC pour la recherche sur le cancer
- Fondation pour la Recherche Médicale
- Fondation de France
- Association Laurette Fugain
- Institut Carnot Lymphome CALYM
- Institut Claudius Regaud Centre de Lutte Contre le Cancer
- Université Toulouse 3 Paul Sabatier
- Union européenne
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