Our research project at a glance
Post-transcriptional gene expression is deregulated in cancer resulting in altered programs of protein biosynthesis that can drive tumor progression and resistance to therapy. Our research program brings together clinicians, biologists and experts in biostatistics to unveil how molecular mechanisms of translational regulation by RNA-binding proteins are orchestrated in cancer cells and are linked to patient outcome.
Alteration of post-transcriptional gene expression regulation is a hallmark of cancer. RNA-binding proteins (RBPs) are master regulators required for all post-transcriptional processes, including transcript maturation, mRNA stability and translation. These factors allow dynamic regulation in normal and various stress conditions, and contribute to deregulations in the RNA metabolism of cancer cells. They can also directly impact genome instability by establishing a direct link between DNA- and RNA-mediated processes. RBPs recognize specific elements of diverse sequences and structures. Among these, RNA G-quadruplex structures have been shown to affect the expression of cancer relevant genes by modulating post-transcriptional steps.
Our research focuses on understanding the role of RBPs in post-transcriptional gene expression reprogramming in response to stress and to the deregulation associated to cancer pathobiology.
Our objectives are:
- to provide a mechanistic and functional understanding into how RBPs impact on cancer development, progression and treatment,
- to improve our understanding of RNA G-quadruplexes regulation and targeting in cancer cells,
- to investigate the emerging concept that DNA-damage proteins, beside effects on DNA and signaling, target mRNAs to regulate post-transcriptional gene expression.
- Post-transcriptional gene expression
- RNA-binding proteins
- mRNA translation
- DNA damage response
- RNA G-quadruplex structure
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Grants and funders
RNA G-quadruplexes: emerging mechanisms in disease Journal Article
Nucleic Acids Res, 45 (4), pp. 1584-1595, 2017, ISSN: 1362-4962 (Electronic) 0305-1048 (Linking).
Oncotarget, 7 (13), pp. 16793-805, 2016, ISSN: 1949-2553 (Electronic) 1949-2553 (Linking).
Trends Cell Biol, 26 (12), pp. 918-933, 2016, ISSN: 1879-3088 (Electronic) 0962-8924 (Linking).
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly Journal Article
Nat Commun, 7 , pp. 11127, 2016, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).
EMBO Rep, 17 (4), pp. 508-18, 2016, ISSN: 1469-3178 (Electronic) 1469-221X (Linking).
Nat Commun, 5 , pp. 4190, 2014, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).
Int J Mol Sci, 15 (2), pp. 2172-90, 2014, ISSN: 1422-0067 (Electronic) 1422-0067 (Linking).
Genes Dev, 28 (4), pp. 357-71, 2014, ISSN: 1549-5477 (Electronic) 0890-9369 (Linking).
Genes Dev, 25 (3), pp. 220-5, 2011, ISSN: 1549-5477 (Electronic) 0890-9369 (Linking).