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X-WR-CALNAME:Centre de Recherches en Cancérologie de Toulouse
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X-WR-CALDESC:Évènements pour Centre de Recherches en Cancérologie de Toulouse
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251204T100000
DTEND;TZID=Europe/Paris:20251204T120000
DTSTAMP:20260428T205641
CREATED:20251106T141053Z
LAST-MODIFIED:20251201T095446Z
UID:62687-1764842400-1764849600@www.crct-inserm.fr
SUMMARY:Séminaire technologique | BIABooster - Adelis
DESCRIPTION:Pour suivre le séminaire à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/seminaire-technologique-biabooster/
LOCATION:Salle Cazaux + Espace détente 1er étage
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/11/seminaire-Adelis.png
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251208T110000
DTEND;TZID=Europe/Paris:20251208T120000
DTSTAMP:20260428T205641
CREATED:20251125T152853Z
LAST-MODIFIED:20251201T095800Z
UID:62891-1765191600-1765195200@www.crct-inserm.fr
SUMMARY:Conférence Dr Robert Ballotti - Identifying the Epigenetic Players Involved in Melanoma Resistance to Targeted Therapies and to the Immune System.
DESCRIPTION:Identifying the Epigenetic Players Involved in Melanoma Resistance to Targeted Therapies and to the Immune System. \nSince 2011-2012 and the use of targeted therapies and immunotherapies in the treatment of metastatic melanoma\, progress in terms of patient survival is evident\, with an increase in median survival from less than a year to over 5 years with immunotherapies. However\, almost 50% of patients are in therapeutic dead-end\, due to frequent resistance to treatment.  The main challenge today is to decipher the mechanisms of resistance to targeted therapies (TC) or immunotherapies (IT) and propose therapeutic approaches to block or reverse these processes. \nIn 2018\, we demonstrated that increased cellular levels of NAD+ render melanoma cells resistant to targeted therapies. This resistance is associated with dedifferentiation and specific epigenetic modifications. Focusing on these non-genetic resistance patterns associated with dedifferentiation\, we have identified epigenetic players whose inhibition resensitizes melanoma cells to TCs and increases their immunogenicity. \nOur data identify epigenetic players involved in the acquisition of resistance to TC and in the alteration of the immune response in melanoma cells. This results lay the foundations for new therapeutic strategies targeting epigenetic alterations to overcome resistance. \nPour suivre la conférence à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-dr-robert-ballotti-identifying-the-epigenetic-players-involved-in-melanoma-resistance-to-targeted-therapies-and-to-the-immune-system/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/11/conf-robert-ballotti.png
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251212T133000
DTEND;TZID=Europe/Paris:20251212T170000
DTSTAMP:20260428T205641
CREATED:20251126T083806Z
LAST-MODIFIED:20251126T083806Z
UID:62898-1765546200-1765558800@www.crct-inserm.fr
SUMMARY:Soutenance de thèse de Karina Cancino - Pôle Techno
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-de-karina-cancino-pole-techno/
LOCATION:Salle Cazaux
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2023/07/these5.png
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251218T093000
DTEND;TZID=Europe/Paris:20251218T113000
DTSTAMP:20260428T205641
CREATED:20251126T095431Z
LAST-MODIFIED:20251208T135350Z
UID:62911-1766050200-1766057400@www.crct-inserm.fr
SUMMARY:Workshop : Signal\, Metabolize\, Dysfunction: Mechanisms in Blood & Vascular Disease
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/mini-symposium/
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/jpeg:https://www.crct-inserm.fr/wp-content/uploads/2025/11/Workshop_2025_12_18_RD-2.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251230T110000
DTEND;TZID=Europe/Paris:20251230T120000
DTSTAMP:20260428T205641
CREATED:20251219T153325Z
LAST-MODIFIED:20251219T153325Z
UID:63123-1767092400-1767096000@www.crct-inserm.fr
SUMMARY:Conférence : Integrating biochemical cues of the extracellular matrix with cell metabolism in metastatic pancreatic ductal adenocarcinoma - George Efthymiou\, PhD
DESCRIPTION:Integrating biochemical cues of the extracellular matrix with cell metabolism in metastatic pancreatic ductal adenocarcinoma \nSynopsis \nPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal cancer with worryingly increasing incidence in developed countries. Key aspects that underline PDAC aggressiveness are the pronounced desmoplasia and the metabolic adaptability\, features that are commonly found in the primary and the metastatic site. Desmoplasia refers to the enhanced production and deposition of extracellular matrix (ECM) components\, which results to dramatic alterations in tissue architecture. Within this metabolically challenging tumor microenvironment (TME)\, tumor cells promote metabolic adaptations to maintain tumorigenic properties\, including proliferation\, chemoresistance\, and metastatic dissemination and expansion. \nIn this talk I will illustrate examples of ECM-driven tumorigenic properties\, such as the capacity of cells to alleviate the effects of chemotherapy by promoting DNA repair mechanisms. I will also present ECM-driven metabolic adaptations in the primary PDAC that contribute to chemoresistance. More specifically\, I will focus on the nucleotide imbalance observed in PDAC\, and reported in other solid cancers\, and describe the role of guanylates as mediators of chemoresistance. Relevant strategies to improve responses to therapy will be discussed. \nFinally\, I will share preliminary results on the emerging notion of the liver pre-metastatic niche (PMN) in PDAC. The PMN comprises ECM and metabolic alterations that favor metastatic cell seeding and subsequent metastatic expansion. The exploration of these alterations may help slow down or halt metastatic dissemination and increase the number of eligible patients for surgical resection.
URL:https://www.crct-inserm.fr/evenement/conference-integrating-biochemical-cues-of-the-extracellular-matrix-with-cell-metabolism-in-metastatic-pancreatic-ductal-adenocarcinoma-george-efthymiou-phd/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/12/Conf-G.-George-Efthymiou.png
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